Search results for " Models"

showing 10 items of 4240 documents

Antibiotic use and associated factors in a large sample of hospitalised older people

2019

Objectives: The aims of this study were to assess (i) the prevalence of antibiotic use, (ii) factors associated with their use and (iii) the association with in-hospital mortality in a large sample of hospitalised older people in Italy.Methods: Data were obtained from the 2010-2017 REPOSI register held in more than 100 internal medicine and geriatric wards in Italy. Patients aged >= 65 years with at least one antibiotic prescription during their hospitalisation were selected. Multivariable logistic regression models were used to determine factors associated with antibiotic use.Results: A total of 5442 older patients were included in the analysis, of whom 2786 (51.2%) were prescribed anti…

RegistrieMale0301 basic medicineAntibioticsLogistic regression0302 clinical medicineDrug Prescription80 and overPrevalenceImmunology and AllergyLS4_4Hospital MortalityRegistries030212 general & internal medicineMultivariate AnalysiRespiratory Tract InfectionsAged 80 and overAnti-Bacterial AgentsHospitalizationItalyAntibiotic useFemaleHumanMicrobiology (medical)medicine.medical_specialtyLogistic ModelInternal medicine wardmedicine.drug_class030106 microbiologyImmunologySocio-culturaleDrug PrescriptionsMicrobiologyOdds03 medical and health sciencesAntibiotic resistanceAnti-Bacterial AgentmedicineAntibiotic use; Internal medicine ward; Older people; Aged; Aged 80 and over; Anti-Bacterial Agents; Drug Prescriptions; Female; Geriatric Assessment; Hospital Mortality; Hospitalization; Humans; Italy; Logistic Models; Male; Multivariate Analysis; Prevalence; Registries; Respiratory Tract InfectionsHumansMedical prescriptionAntibiotic useGeriatric AssessmentAgedbusiness.industryConfidence intervalLogistic ModelsAntibiotic use Internal medicine ward Older peopleMultivariate AnalysisEmergency medicineOlder peopleOlder peoplebusinessAntibiotic use; Internal medicine ward; Older peopleJournal of Global Antimicrobial Resistance
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Relationship between low Ankle-Brachial Index and rapid renal function decline in patients with atrial fibrillation: a prospective multicentre cohort…

2015

Objective: To investigate the relationship between Ankle-Brachial Index (ABI) and renal function progression in patients with atrial fibrillation (AF). Design: Observational prospective multicentre cohort study. Setting: Atherothrombosis Center of I Clinica Medica of 'Sapienza' University of Rome; Department of Medical and Surgical Sciences of University Magna Græcia of Catanzaro; Atrial Fibrillation Registry for Ankle-Brachial Index Prevalence Assessment-Collaborative Italian Study. Participants: 897 AF patients on treatment with vitamin K antagonists. Main outcome measures: The relationship between basal ABI and renal function progression, assessed by the estimated Glomerular Filtration R…

RegistrieMaleAnkle brachial index atrial fibrillation renal functionCross-sectional studyAngiotensin-Converting Enzyme InhibitorsBlood PressureCardiovascular Medicineurologic and male genital diseasesKidneyRisk FactorsAtrial FibrillationOdds RatioSurveys and Questionnaireatrial fibrillation1506Prospective StudiesRenal InsufficiencyPractice Patterns Physicians'Prospective cohort studyMedicine (all)Atrial fibrillationGeneral MedicineMiddle Agedmedicine.anatomical_structureItalyHypertensioncardiovascular systemCardiologyDisease ProgressionFemaleVitamin K antagonistABICohort studyHumanGlomerular Filtration RateAnkle brachial index; atrial fibrillation; renal function1683medicine.medical_specialtyLogistic ModelNon-Vitamin K oral anticoagulantRenal functionrenal function declineAnkle-Brachial IndexNOInternal medicineAged; Angiotensin-Converting Enzyme Inhibitors; Atrial Fibrillation; Cross-Sectional Studies; Disease Progression; Female; Humans; Hypertension; Italy; Kidney; Logistic Models; Male; Middle Aged; Odds Ratio; Prospective Studies; Renal Insufficiency; Risk Factors; Ankle Brachial Index; Blood Pressure; Glomerular Filtration Rate; Medicine (all)medicineInternal MedicineHumansAnkle Brachial Indexcardiovascular diseasesIntensive care medicineAgedCross-Sectional StudieAntithrombotic therapybusiness.industryRisk FactorResearchrenal functionAnticoagulantAngiotensin-Converting Enzyme InhibitorOdds ratiomedicine.diseasebody regionsProspective StudieBlood pressureAtrial fibrillation; Ankle-Brachial Index; renal function declineCross-Sectional StudiesLogistic ModelsAnklebusinessABI renal function atrial fibrillation
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Frequency of Left Ventricular Hypertrophy in Non-Valvular Atrial Fibrillation

2015

Left ventricular hypertrophy (LVH) is significantly related to adverse clinical outcomes in patients at high risk of cardiovascular events. In patients with atrial fibrillation (AF), data on LVH, that is, prevalence and determinants, are inconsistent mainly because of different definitions and heterogeneity of study populations. We determined echocardiographic-based LVH prevalence and clinical factors independently associated with its development in a prospective cohort of patients with non-valvular (NV) AF. From the "Atrial Fibrillation Registry for Ankle-brachial Index Prevalence Assessment: Collaborative Italian Study" (ARAPACIS) population, 1,184 patients with NVAF (mean age 72 ± 11 yea…

RegistrieMaleCross-sectional studyMyocardial InfarctionLongitudinal StudieLeft ventricular hypertrophyCohort Studiesnon-valvular atrial fibrillationAtrial Fibrillation80 and overPrevalenceechocardiographyMyocardial infarctionLongitudinal StudiesProspective StudiesRegistriesProspective cohort studyUltrasonographyAged 80 and overeducation.field_of_studyMedicine (all)Atrial fibrillationDiabetes MellituMiddle AgedLeft Ventricularleft ventricular hypertrophyItalyHypertensionCardiologyAge Distribution; Aged; Aged 80 and over; Ankle Brachial Index; Atrial Fibrillation; Cohort Studies; Cross-Sectional Studies; Diabetes Mellitus; Female; Humans; Hypertension; Hypertrophy Left Ventricular; Italy; Logistic Models; Longitudinal Studies; Male; Middle Aged; Myocardial Infarction; Peripheral Arterial Disease; Prevalence; Prospective Studies; Ultrasonography; Registries; Cardiology and Cardiovascular Medicine; Medicine (all)Hypertrophy Left VentricularFemaleCardiology and Cardiovascular MedicineHumanmedicine.medical_specialtyLogistic ModelPopulationConcentric hypertrophySocio-culturalenon-valvular atrial fibrillation left ventricular hypertrophy echocardiography cardiovascular diseasesPeripheral Arterial DiseaseAge DistributionInternal medicinemedicineDiabetes MellitusHumansAnkle Brachial Indexcardiovascular diseaseseducationAgedCross-Sectional Studiebusiness.industryAge Distribution; Aged; Aged 80 and over; Ankle Brachial Index; Atrial Fibrillation; Cohort Studies; Cross-Sectional Studies; Diabetes Mellitus; Female; Humans; Hypertension; Hypertrophy Left Ventricular; Italy; Logistic Models; Longitudinal Studies; Male; Middle Aged; Myocardial Infarction; Peripheral Arterial Disease; Prevalence; Prospective Studies; Ultrasonography; Registries; Cardiology and Cardiovascular MedicineOdds ratioHypertrophymedicine.diseasecardiovascular diseasesProspective StudieCross-Sectional StudiesLogistic ModelsCohort StudiebusinessAge Distribution; Aged; Aged 80 and over; Ankle Brachial Index; Atrial Fibrillation; Cohort Studies; Cross-Sectional Studies; Diabetes Mellitus; Female; Humans; Hypertension; Hypertrophy Left Ventricular; Italy; Logistic Models; Longitudinal Studies; Male; Middle Aged; Myocardial Infarction; Peripheral Arterial Disease; Prevalence; Prospective Studies; Ultrasonography; Registries
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Joint use of cardio-embolic and bleeding risk scores in elderly patients with atrial fibrillation

2013

Background Scores for cardio-embolic and bleeding risk in patients with atrial fibrillation are described in the literature. However, it is not clear how they co-classify elderly patients with multimorbidity, nor whether and how they affect the physician's decision on thromboprophylaxis. Methods Four scores for cardio-embolic and bleeding risks were retrospectively calculated for ≥ 65 year old patients with atrial fibrillation enrolled in the REPOSI registry. The co-classification of patients according to risk categories based on different score combinations was described and the relationship between risk categories tested. The association between the antithrombotic therapy received and t…

RegistrieMaleEmbolismAtrial fibrillation; Bleeding risk; Cardioembolic risk; Elderly; Prediction guides; Thromboprophylaxis; Aged; Aged; 80 and over; Anticoagulants; Atrial Fibrillation; Embolism; Female; Hemorrhage; Humans; Logistic Models; Male; Platelet Aggregation Inhibitors; Retrospective Studies; Stroke; Warfarin; Registries; Risk Assessment; Internal MedicineRetrospective Studiearitmiableeding risk scoreAtrial Fibrillation80 and overatrial fibrillationRegistriesStrokeAged 80 and overAspirineducation.field_of_studyElderly Atrial fibrillation Prediction guides Bleeding risk Cardioembolic risk ThromboprophylaxisPrediction guidesAtrial fibrillationCardiovascular diseaseStrokecardio-embolic scorePlatelet aggregation inhibitorcardio-embolic scores; bleeding risk scores; elderly; Atrial FibrillationFemaleRisk assessmentmedicine.drugHumanmedicine.medical_specialtyLogistic Modelcardio-embolic scoresPopulationHemorrhageRisk AssessmentelderlyCARDIOEMBOLIC RISKNOBLEEDING RISKInternal medicinemedicineElderly; Atrial fibrillation; Prediction guides; Bleeding risk; Cardioembolic riskbleeding risk scoresPrediction guideInternal MedicineHumanseducationThromboprophylaxisAgedRetrospective StudiesELDERLYbusiness.industryPlatelet Aggregation InhibitorSettore MED/09 - MEDICINA INTERNAWarfarinAnticoagulantAnticoagulantsRetrospective cohort studyAtrial fibrillation; Bleeding risk; Cardioembolic risk; Elderly; Prediction guides; Thromboprophylaxis; Aged; Aged 80 and over; Anticoagulants; Atrial Fibrillation; Embolism; Female; Hemorrhage; Humans; Logistic Models; Male; Platelet Aggregation Inhibitors; Retrospective Studies; Stroke; Warfarin; Registries; Risk Assessment; Internal Medicinemedicine.diseaseSurgeryLogistic ModelsThromboprophylaxiWarfarinbusinessPlatelet Aggregation Inhibitors
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Mortality rate and risk factors for gastrointestinal bleeding in elderly patients

2019

Abstract Background Gastrointestinal bleeding (GIB) is burdened by high mortality rate that increases with aging. Elderly patients may be exposed to multiple risk factors for GIB. We aimed at defining the impact of GIB in elderly patients. Methods Since 2008, samples of elderly patients (age ≥ 65 years) with multimorbidity admitted to 101 internal medicine wards across Italy have been prospectively enrolled and followed-up (REPOSI registry). Diagnoses of GIB, length of stay (LOS), mortality rate, and possible risk factors, including drugs, index of comorbidity (Cumulative Illness Rating Scale [CIRS]), polypharmacy, and chronic diseases were assessed. Adjusted multivariate logistic regressio…

RegistrieMaleSettore MED/09 - Medicina Interna030204 cardiovascular system & hematologySeverity of Illness Index0302 clinical medicineRisk Factors80 and over030212 general & internal medicineHospital MortalityProspective StudiesRegistriesProspective cohort studyMultivariate AnalysiAged 80 and overDiverticulosisMortality rateDiverticulosiGastric ulcerAnemiaAnemia; Anticoagulant; Antiplatelet drug; Diverticulosis; Gastric ulcer; Multimorbidity; Internal MedicineItalyPlatelet aggregation inhibitorFemaleGastrointestinal HemorrhageAntiplatelet drugHumanGastrointestinal bleedingmedicine.medical_specialtyLogistic ModelAnemiaSocio-culturaleAnemia Anticoagulant Antiplatelet drug Diverticulosis Gastric ulcer Multimorbidity03 medical and health sciencesInternal medicineSeverity of illnessInternal MedicinemedicineHumansAnemia; Anticoagulant; Antiplatelet drug; Diverticulosis; Gastric ulcer; Multimorbidity; Aged; Aged 80 and over; Female; Gastrointestinal Hemorrhage; Hospital Mortality; Humans; Italy; Length of Stay; Logistic Models; Male; Multivariate Analysis; Platelet Aggregation Inhibitors; Prospective Studies; Registries; Risk Factors; Severity of Illness Index; MultimorbidityAgedPolypharmacybusiness.industryPlatelet Aggregation InhibitorRisk FactorAnemia; Anticoagulant; Antiplatelet drug; Diverticulosis; Gastric ulcer; MultimorbidityAnticoagulantMultimorbidityAnemia Anticoagulant Antiplatelet drug Diverticulosis Gastric ulcer Multimorbidity Aged Aged 80 and over Female Gastrointestinal Hemorrhage Hospital Mortality Humans Italy Length of Stay Logistic Models Male Multivariate Analysis Platelet Aggregation Inhibitors Prospective Studies Registries Risk Factors Severity of Illness Index MultimorbidityLength of Staymedicine.diseaseComorbidityProspective StudieLogistic ModelsMultivariate AnalysisbusinessPlatelet Aggregation Inhibitors
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Incidence and prognostic factors related to major adverse cerebrovascular events in patients with complex aortic diseases treated by the chimney tech…

2018

Abstract Objective Endovascular aneurysm repair (EVAR) with the chimney technique (ch-EVAR) has been used for the treatment of aortic aneurysms as an alternative approach to fenestrated endografting or open repair. Nonetheless, the need for an upper extremity arterial access may contribute to a higher risk for periprocedural cerebrovascular events. This study reports on the perioperative cerebral and major adverse cardiac and cerebrovascular events (MACCE) after ch-EVAR. Methods The PERICLES registry (PERformance of the chImney technique for the treatment of Complex aortic pathoLogiES) is an international, retrospective multicenter study evaluating the performance of ch-EVAR for the treatme…

RegistrieMaleTime Factorsmedicine.medical_treatment030204 cardiovascular system & hematologySettore MED/22 - Chirurgia VascolareEndovascular aneurysm repair0302 clinical medicineRetrospective StudieRisk FactorsCause of DeathCarotid artery diseaseOdds RatioRegistries030212 general & internal medicineMultivariate AnalysiStrokeCause of deathAged 80 and overIncidenceEndovascular ProceduresAtrial fibrillationchimney technique; stroke; aortic archMiddle AgedStrokeHeart DiseaseTreatment OutcomeIschemic Attack TransientCerebrovascular DisorderCardiologyFemaleCardiology and Cardiovascular MedicineHumanAdultmedicine.medical_specialtyAcute coronary syndromeLogistic ModelTime FactorHeart DiseasesOperative TimeAortic DiseasesBlood Vessel Prosthesis Implantation03 medical and health sciencesInternal medicinemedicineHumanscardiovascular diseasesAgedRetrospective StudiesEndovascular ProcedureChi-Square Distributionbusiness.industryRisk FactorOdds ratioPerioperativeAortic Diseasemedicine.diseaseSurgeryCerebrovascular DisordersLogistic ModelsMultivariate AnalysisSurgerybusiness
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Cutting Edge: Trans-Signaling via the Soluble IL-6R Abrogates the Induction of FoxP3 in Naive CD4+CD25− T Cells

2007

Abstract Chronic inflammatory diseases may develop when regulatory T cells (Tregs) fail to control the balance between tolerance and immunity. Alternatively, activated immune cells might prevent the induction or activation of Tregs in such diseases. In this study, we demonstrate that trans-signaling into T cells via the soluble IL-6 receptor completely abrogates the de novo induction of adaptive Tregs. Mechanistically, IL-6 trans-signaling augmented the expression of the TGF-β signaling inhibitor SMAD7. Consequently, SMAD7 overexpression in T cells using newly created transgenic mice rendered CD4+CD25− T cells resistant to the induction of FoxP3. Finally, IL-6 trans-signaling inhibited Treg…

Regulatory T cellImmunologyMice Transgenicchemical and pharmacologic phenomenaMice SCIDBiologyT-Lymphocytes RegulatoryAutoimmune DiseasesSmad7 ProteinMiceInterleukin 21Immune systemTransforming Growth Factor betaImmunitymedicineAnimalsHumansImmunology and AllergyCytotoxic T cellIL-2 receptorInflammationMice Inbred BALB CInterleukin-6ZAP70FOXP3Forkhead Transcription FactorsColitisReceptors Interleukin-6Cell biologyDisease Models Animalmedicine.anatomical_structureGene Expression RegulationChronic DiseaseImmunologySignal TransductionThe Journal of Immunology
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Individual and Contextual Determinants of Cruise Passengers’ Behavior at Their Destination: A Survival Approach

2020

The proposed study will present an analysis of cruise passengers’ behavior at their destination. Mobility behavior will be analyzed in relation to socio-demographic characteristics through a survival modeling approach. Data collected through GPS devices on cruise passengers’ behavior in the ports of Palermo and Dubrovnik will be analyzed in order to determine similarities and differences among cruise passengers’ behaviors at their destination, according to socio-demographic characteristics. The authors of this chapter contend that the results of this research, involving the processing and the analysis of GPS data, will be of interest from methodological and destination management perspectiv…

Relation (database)Computer sciencebusiness.industryCruiseComputerApplications_COMPUTERSINOTHERSYSTEMSDestination managementGPS tracking data Spatial behavior Survival models Tourist mobilityTransport engineeringOrder (business)Spatial behaviorGps dataGlobal Positioning SystemSurvival modelingSettore SECS-S/05 - Statistica Socialebusiness
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The finite element implementation of 3D fractional viscoelastic constitutive models

2018

Abstract The aim of this paper is to present the implementation of 3D fractional viscoelastic constitutive theory presented in Alotta et al., 2016 [1]. Fractional viscoelastic models exactly reproduce the time dependent behaviour of real viscoelastic materials which exhibit a long “fading memory”. From an implementation point of view, this feature implies storing the stress/strain history throughout the simulations which may require a large amount of memory. We propose here a number of strategies to effectively limit the memory required. The form of the constitutive equations are summarized and the finite element implementation in a Newton-Raphson integration scheme is described in detail. …

RelaxationComputer scienceSubroutineConstitutive equation3D constitutive models; Creep; Fractional viscoelasticity; Numerical modelling; Relaxation; Analysis; Engineering (all); Computer Graphics and Computer-Aided Design; Applied Mathematics02 engineering and technologyViscoelasticityStress (mechanics)Engineering (all)0203 mechanical engineeringFractional viscoelasticityApplied mathematicsLimit (mathematics)Applied MathematicsGeneral EngineeringAnalysiCreep021001 nanoscience & nanotechnologyComputer Graphics and Computer-Aided DesignFinite element method020303 mechanical engineering & transportsNumerical modellingBenchmark (computing)3D constitutive model0210 nano-technologyAnalysisQuasistatic process
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Fuel cell modelling and test: Experimental validation of model accuracy

2013

In the last few years, renewable energies have been encouraged by worldwide governments to meet energy saving policies. Among renewable energy sources, fuel cells have attracted much interest for a wide variety of research areas. Fuel cell-based residential-scaled power supply systems take advantage of simultaneous generation of power and heat, reducing the overall fossil fuel consumption and utilities cost. Modeling is one of the most important topics concerning fuel cell use. In this paper, a measurement-based steady-state and dynamic fuel cell model is presented. The proposed modelling approach is implemented on a 5kW Proton Exchange Membrane Fuel Cell. The parameters identification proc…

Renewable energyEngineeringRenewable Energy Sustainability and the Environmentbusiness.industryFuel cellModelingProton exchange membrane fuel cellEnergy Engineering and Power TechnologyProton exchange membrane fuel cellMechanical engineeringSettore ING-IND/32 - Convertitori Macchine E Azionamenti ElettriciSettore ING-INF/01 - ElettronicaAutomotive engineeringRenewable energyPower (physics)Identification (information)Nuclear Energy and EngineeringErrors-in-variables modelsFuel cellsbusinessMATLABcomputerEnergy (signal processing)computer.programming_language4th International Conference on Power Engineering, Energy and Electrical Drives
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