6533b7dafe1ef96bd126f6ae

RESEARCH PRODUCT

Frequency of Left Ventricular Hypertrophy in Non-Valvular Atrial Fibrillation

Proietti MMarra AmTassone EjDe Vuono SCorrao SGobbi PPerticone FCorazza GrBasili SLip GyVioli FRaparelli VArapacis Study InvestigatorsGis GroupAlessandri CesareServiddio GaetanoFascetti StefanoSerra PietroPalange PaoloGreco EleonoraBruno GraziellaAverna MaurizioGiammanco AntoninaSposito PietroDe Cristofaro RaimondoDe Gennaro LeonardoLoria PaolaPellegrini ElisaCominacini LucianoChiara MozziniSprovieri MarioSpagnuolo VitalianoCerqua GiannantonioCerasola GiovanniMulé GiuseppeBarbagallo MarioLo Sciuto SalvatoreMonteverde AlfredoSaitta AntoninoAlberto Lo GulloMalatino LorenzoCilia ChiaraLicata GiuseppeTuttolomondo AntoninoConigliaro RobertaPinto AntonioDi Raimondo DomenicoSignorelli SantoAnzaldi MassimilianoDe Palma DanielaGalderisi MaurizioCudemo GiuseppeGalletti FerruccioFazio ValeriaDe Luca NicolaMeccariello AlfonsoCaputo DarioDe Donato Maria TeresaIannuzi ArcangeloBresciani AlessandroGiunta RiccardoCimini ClaudiaDurante Mangoni EmanueleAgrusta FedericaIorio FedericaAdinolfi Luigi ESellitto AusiliaRestivo LucianoBellis PaoloTirelli PaoloSacerdoti DavidPesce PaolaVanni DinoIuliano LuigiCiacciarelli MarcoPacelli AntonioPalazzuoli AlbertoCacciafesta MauroGueli NicolaCapeci WilliamTarquinio NicolaPellegrini FrancescoVincentelli Giovanni MariaRavallese FerdinandoSantini ClaudioLetizia ClaudioPetramala LuigiZinnamosca LauraCilli MirellaSavoriti ClaudioFalaschi PaoloMartocchia AntonioStefanelli ManuelaMarigliano VincenzoLo Iacono CristinaBrusco SimonaBertazzoni GiulianoAttalla El Halabieh EliasParadiso MicheleLizzi Eugenio MariaTimmi StefanoBattisti PaolaCerci SabinaCiavolella MassimoDi Veroli ClaudioMalci FrancescoDe Ciocchis AnitaAbate DamianoCastellino PietroCurto IreneVecchio ClaudiaMannarino ElmoPasqualini LeonellaFattori ChiaraPende AldoDenegri AndreaArtom NathanRicchio RobertoFimognari Filippo LucaAlletto MaurizioMessina SimonaSesti GiorgioArturi FrancoGrembiale AlessandroPerticone FrancescoMaio RaffaeleScarpino Paola ElisaCarullo GiuseppeSciacqua AngelaFrugiuele PierluigiSpagnuolo VitalianoBattaglia GiuseppeVidili GianpaoloAtzori SebastianaDelitala GiuseppeDavì GiovanniAngelucci ErmannoSestili SimonaTraisci GiancarloDe Feudis LucreziaDi Michele DarioFava AlessandraBalsano ClaraDe Ciantis PierpaoloDesideri GiovambattistaCamerota AntonioMigliacci RinoPorciello GiovanniMezzetti MatteoGresele PaoloVedovati CristinaFierro TizianaPuccetti LucaScarpini FrancescaBertolotti MarcoMussi ChiaraBoddi MariaSavino AndreaContri SilviaSaller AloisFabris FabrizioPesavento RaffaeleFilippi LuciaVedovetto ValentinaPuato MassimoFabris FabrizioTreleani MartinaDe Luca ElisabettaDe Zaiacomo FrancescaGiantin ValterSemplicini AndreaMinuz PietroCalabria StefanoRomano SimoneFantin FrancescoManica AngelaStockner IngridPattis PeterGutmann BernhardCatena CristianaColussi GianlucaAnnoni GiorgioBruni Adriana AntonellaCastagna AlbertoSpinelli DianaCorazza Gino RobertoMiceli EmanuelaPadulaSchinco GiuseppinaSpreafico SibillaSecchi BeatriceVanoli MassimoCasella GianlucaSerra Maria GraziaLongo StefaniaAntonaci SalvatoreBelfiore AnnaRicci LaraVentrella FrancescoIamele LuigiBianco CesareSantovito DonatoCipollone FrancescoNicolai SalvatoreSalvati FilippoRini Giovan BattistaScozzari FrancescaMuiesan Maria LorenzaSalvetti MassimoBazza AbramoPicardi AntonioDe Vincentis AntonioCosio PaoloTerzolo MassimoMadaffari BrunoParasporo BrunoFenoglio LuigiBracco ChristianMelchio RemoGentili TamiraSalvi AldoNitti CinziaFalsetti LGabrielli ArmandoPaglione IvanoCapucci AlessandroBrambatti MichelaSparagna ArmandoTirotta DanielaAndreozzi PaolaEttorre EvaristoViscogliosi GiovanniRossi Fanelli FillippoDelfino MassimoGlorioso NicolaMelis GiadaMarras GianfrancaMatta MichelaSacco AndreaStellitano ElioScordo AnnaRusso FrancoCaruso Assunta AntoniettaPorreca EttoreSantilli FrancescaTana MarcoFerri ClaudioGrassi DavideCheli PaolaPortincasa PieroMuscianisi GiuseppeGiordani SaraStanghellini VincenzoSabbà CarloSuppressa PatriziaMancuso GerardoBartone MosèCalipari DanielaArcidiacono GiuseppeBellanuova IgnazioFerraro MariaScalzo AntonioMarigliano GiampietroCozzolino DomenicoLampitella AntonioAcri VeraGalasso DomenicoMazzei FrancescaGalasso SalvatoreBuratti AlbertoPorta MassimoBrizzi Maria FeliceFattorini AnnalisaSampietro FrancescaD’angelo ArmandoPala MarcoFabbian FabioManfredini RobertoMoroni CarloValente LuciaLopreiato FrancescoParente FernandoMoia MarcoBraham SimonRossi MarcoPesce MargheritaGentile AdelinaCatozzo VaniaDi Napoli MariarosariaBaciarello GiacintoRancan ElenaAgeno WalterGuasti LuiginaCiccaglioni AntonioNegri SilviaPolselli MarcoAbbate RosannaMarcucci RossellaCangemi RobertoPignataro Francesca SerenaMarco ProiettiPastori DanieleFerro DomenicoLoffredo LorenzoPerri LudovicaCatasca ElisaRaparelli ValeriaNapoleone LauraTalerico GiovanniCalvieri CamillaVicario TommasaRusso RobertaSaliola MirellaDel Ben MariaAngelico FrancescoBucci TommasoBaratta FrancescoData And Safety Monitoring Board (Dsmb): Vestri Anna RitaFarcomeni AlessioDi Tanna GianlucaStudy Coordinators: Basili StefaniaDavi’ GiovanniSteering Committee Of Arapacis Study: Violi FrancescoPerticone FrancescoLip Gregory YhHiatt William RVestri Anna RitaCorazza Gino RobertoMannucci Pier MannuccioLicata GiuseppeMoroni CarloProietti MarcoAnzaldi MassimilianoBazzini CristinaBianchi Paola IlariaBenedetta BoariBracco ChristianBuonauro AgostinoButtà CarmeloElena BuzzettiCalabria StefanoCapeci WilliamCarleo PietroCarrabba Maria DomenicaCastorani LuigiCecchetto LaraCimini ClaudiaColombo Barbara MariaDe Giorgi AlfredoDe Vuono StefanoDenegri AndreaDel Corso LisetteDi Giosia PaoloDurante Mangoni EmanueleFalsetti LorenzoForgione AlessandraGrassi DavideGrembiale AlessandroHijazi DanielIamele LuigiLorusso GiusiAlberto M. MarraMasala MaristellaMontebianco Abenavoli LudovicoMurgia GiuseppeNaccarato PaolaPattoneri PaoloPerego FrancescaPesce PaolaPetramala LuigiPinto DanielaPinna Miriam Pretti VincenzoPucci GiacomoRaparelli ValeriaSalinaro FrancescoSantilli FrancescaScarpini FrancescaSirico DomenicoSuppressa PatriziaTassone Eliezer JosephTorres DanieleVazzana NataleVecchio Claudia RitaVidili GianpaoloVitale Francesco

subject

RegistrieMaleCross-sectional studyMyocardial InfarctionLongitudinal StudieLeft ventricular hypertrophyCohort Studiesnon-valvular atrial fibrillationAtrial Fibrillation80 and overPrevalenceechocardiographyMyocardial infarctionLongitudinal StudiesProspective StudiesRegistriesProspective cohort studyUltrasonographyAged 80 and overeducation.field_of_studyMedicine (all)Atrial fibrillationDiabetes MellituMiddle AgedLeft Ventricularleft ventricular hypertrophyItalyHypertensionCardiologyAge Distribution; Aged; Aged 80 and over; Ankle Brachial Index; Atrial Fibrillation; Cohort Studies; Cross-Sectional Studies; Diabetes Mellitus; Female; Humans; Hypertension; Hypertrophy Left Ventricular; Italy; Logistic Models; Longitudinal Studies; Male; Middle Aged; Myocardial Infarction; Peripheral Arterial Disease; Prevalence; Prospective Studies; Ultrasonography; Registries; Cardiology and Cardiovascular Medicine; Medicine (all)Hypertrophy Left VentricularFemaleCardiology and Cardiovascular MedicineHumanmedicine.medical_specialtyLogistic ModelPopulationConcentric hypertrophySocio-culturalenon-valvular atrial fibrillation left ventricular hypertrophy echocardiography cardiovascular diseasesPeripheral Arterial DiseaseAge DistributionInternal medicinemedicineDiabetes MellitusHumansAnkle Brachial Indexcardiovascular diseaseseducationAgedCross-Sectional Studiebusiness.industryAge Distribution; Aged; Aged 80 and over; Ankle Brachial Index; Atrial Fibrillation; Cohort Studies; Cross-Sectional Studies; Diabetes Mellitus; Female; Humans; Hypertension; Hypertrophy Left Ventricular; Italy; Logistic Models; Longitudinal Studies; Male; Middle Aged; Myocardial Infarction; Peripheral Arterial Disease; Prevalence; Prospective Studies; Ultrasonography; Registries; Cardiology and Cardiovascular MedicineOdds ratioHypertrophymedicine.diseasecardiovascular diseasesProspective StudieCross-Sectional StudiesLogistic ModelsCohort StudiebusinessAge Distribution; Aged; Aged 80 and over; Ankle Brachial Index; Atrial Fibrillation; Cohort Studies; Cross-Sectional Studies; Diabetes Mellitus; Female; Humans; Hypertension; Hypertrophy Left Ventricular; Italy; Logistic Models; Longitudinal Studies; Male; Middle Aged; Myocardial Infarction; Peripheral Arterial Disease; Prevalence; Prospective Studies; Ultrasonography; Registries

description

Left ventricular hypertrophy (LVH) is significantly related to adverse clinical outcomes in patients at high risk of cardiovascular events. In patients with atrial fibrillation (AF), data on LVH, that is, prevalence and determinants, are inconsistent mainly because of different definitions and heterogeneity of study populations. We determined echocardiographic-based LVH prevalence and clinical factors independently associated with its development in a prospective cohort of patients with non-valvular (NV) AF. From the "Atrial Fibrillation Registry for Ankle-brachial Index Prevalence Assessment: Collaborative Italian Study" (ARAPACIS) population, 1,184 patients with NVAF (mean age 72 ± 11 years; 56% men) with complete data to define LVH were selected. ARAPACIS is a multicenter, observational, prospective, longitudinal on-going study designed to estimate prevalence of peripheral artery disease in patients with NVAF. We found a high prevalence of LVH (52%) in patients with NVAF. Compared to those without LVH, patients with AF with LVH were older and had a higher prevalence of hypertension, diabetes, and previous myocardial infarction (MI). A higher prevalence of ankle-brachial index ≤0.90 was seen in patients with LVH (22 vs 17%, p = 0.0392). Patients with LVH were at significantly higher thromboembolic risk, with CHA2DS2-VASc ≥2 seen in 93% of LVH and in 73% of patients without LVH (p <0.05). Women with LVH had a higher prevalence of concentric hypertrophy than men (46% vs 29%, p = 0.0003). Logistic regression analysis demonstrated that female gender (odds ratio [OR] 2.80, p <0.0001), age (OR 1.03 per year, p <0.001), hypertension (OR 2.30, p <0.001), diabetes (OR 1.62, p = 0.004), and previous MI (OR 1.96, p = 0.001) were independently associated with LVH. In conclusion, patients with NVAF have a high prevalence of LVH, which is related to female gender, older age, hypertension, and previous MI. These patients are at high thromboembolic risk and deserve a holistic approach to cardiovascular prevention.

yearjournalcountryeditionlanguage
2015-01-01
10.1016/j.amjcard.2015.05.060http://hdl.handle.net/11567/930304