Search results for " Models"

Spatio-temporal models: a simple model based on two SVDs for large datasets

2011

Examining business models of Software-as-a-Service companies

2013

Software-as-a-Service Revenue Models

2013

When should software providers maintain their traditional licensing model versus offering software as a service, and which SaaS model is more profitable: rental or pay per use? For customers, what are the trade-offs between traditional licensing, renting, and paying per use? peerReviewed

S. Typhimurium virulence changes caused by exposure to different non-thermal preservation treatments using C. elegans

2017

The aims of this research study were: (i) to postulate Caenorhabditis elegans (C. elegans) as a useful organism to describe infection by Salmonella enterica serovar Typhimurium (S. Typhimurium), and (ii) to evaluate changes in virulence of S. Typhimurium when subjected repetitively to different antimicrobial treatments. Specifically, cauliflower by-product infusion, High Hydrostatic Pressure (HHP), and Pulsed Electric Fields (PEF). This study was carried out by feeding C. elegans with different microbial populations: E. coli OP50 (optimal conditions), untreated S. Typhimurium, S. Typhimurium treated once and three times with cauliflower by-product infusion, S. Typhimurium treated once and f…

Molecular basis of human Usher syndrome: deciphering the meshes of the Usher protein network provides insights into the pathomechanisms of the Usher …

2006

Usher syndrome (USH) is the most frequent cause of combined deaf-blindness in man. It is clinically and genetically heterogeneous and at least 12 chromosomal loci are assigned to three clinical USH types, namely USH1A-G, USH2A-C, USH3A (Davenport, S.L.H., Omenn, G.S., 1977. The heterogeneity of Usher syndrome. Vth Int. Conf. Birth Defects, Montreal; Petit, C., 2001. Usher syndrome: from genetics to pathogenesis. Annu. Rev. Genomics Hum. Genet. 2, 271-297). Mutations in USH type 1 genes cause the most severe form of USH. In USH1 patients, congenital deafness is combined with a pre-pubertal onset of retinitis pigmentosa (RP) and severe vestibular dysfunctions. Those with USH2 have moderate to…

Is there any scaling in the cluster distribution?

1994

We apply fractal analysis methods to investigate the scaling properties in the Abell and ACO catalogs of rich galaxy clusters. We also discuss different technical aspects of the method when applied to data sets with small number of points as the cluster catalogs. Results are compared with simulations based on the Zel'dovich approximation. We limit our analysis to scales less than 100 $\hm$. The cluster distribution show a scale invariant multifractal behavior in a limited scale range. For the Abell catalog this range is 15--60$\hm$, while for the ACO sample it extends to smaller scales. Despite this difference in the extension of the scale--range where scale--invariant clustering takes plac…

On the behavior of a three-dimensional fractional viscoelastic constitutive model

2016

In this paper a three-dimensional isotropic fractional viscoelastic model is examined. It is shown that if different time scales for the volumetric and deviatoric components are assumed, the Poisson ratio is time varying function; in particular viscoelastic Poisson ratio may be obtained both increasing and decreasing with time. Moreover, it is shown that, from a theoretical point of view, one-dimensional fractional constitutive laws for normal stress and strain components are not correct to fit uniaxial experimental test, unless the time scale of deviatoric and volumetric are equal. Finally, the model is proved to satisfy correspondence principles also for the viscoelastic Poisson’s ratio a…

An adaptive multimeme algorithm for designing HIV multidrug therapies.

2007

This paper proposes a period representation for modeling the multidrug HIV therapies and an Adaptive Multimeme Algorithm (AMmA) for designing the optimal therapy. The period representation offers benefits in terms of flexibility and reduction in dimensionality compared to the binary representation. The AMmA is a memetic algorithm which employs a list of three local searchers adaptively activated by an evolutionary framework. These local searchers, having different features according to the exploration logic and the pivot rule, have the role of exploring the decision space from different and complementary perspectives and, thus, assisting the standard evolutionary operators in the optimizati…

Problematic aspects of models of culture in European legal culture and selected personal models of people of the road

2016

the aim of the hereby paper is not to present a standpoint related to the term and structure of culture, it is to present the models of culture from a perspective of scientists that undertake this matter. Therefore, the problematic issues of models of culture have been presented, with regard to differentiation of standpoints presented by authors undertaking the matter. Against this background, the problem of placing personal models of culture within changes that take place in culture, seems to outline distinctively. the issue of personal models is related to the sphere of cultural values. These determine the changes that take place in the area of culture: the deeper the alterations in cultu…

Algorithmic differentiation for cloud schemes (IFS Cy43r3) using CoDiPack (v1.8.1)

2019

Abstract. Numerical models in atmospheric sciences not only need to approximate the flow equations on a suitable computational grid, they also need to include subgrid effects of many non-resolved physical processes. Among others, the formation and evolution of cloud particles is an example of such subgrid processes. Moreover, to date there is no universal mathematical description of a cloud, hence many cloud schemes have been proposed and these schemes typically contain several uncertain parameters. In this study, we propose the use of algorithmic differentiation (AD) as a method to identify parameters within the cloud scheme, to which the output of the cloud scheme is most sensitive. We il…