Search results for " Models"
showing 10 items of 4240 documents
Inhibition of KIF20A by BKS0349 reduces endometriotic lesions in a xenograft mouse model
2019
AbstractSeveral studies have suggested a possible etiological association between ovarian endometriosis and ovarian cancer. Evidence has shown that KIF20A overexpression might confer a malignant phenotype to ovarian tumors by promoting proliferation and inhibiting apoptosis. However, no data about the role of KIF20A in endometriosis have been described. In this study, the human endometrium (n = 4) was transfected by mCherry adenovirus and intraperitoneally implanted in mice. Subsequently, mice were divided in three groups (n = 8/group) that were treated with Vehicle, BKS0349 (KIF20A-antagonist) or cabergoline (dopamine receptor agonist) for 21 days. mCherry-labeled endometriotic lesions wer…
Evaluation of PAI-1 in endometriosis using a homologous immunocompetent mouse model
2018
To analyze the role of PAI-1 (plasminogen activator inhibitor 1) in endometriotic lesion growth, we studied the effect of PAI-1 inhibition by PAI-039 using a homologous mouse model of endometriosis that allows noninvasive monitoring. Endometrial tissue from donor mice was collected, labeled with mCherry adenovirus, and implanted into a subcutaneous pocket on the ventral abdomen of recipient mice. Seven days after transplantation, mice were randomly allocated in two groups and treated once daily for 2 weeks with either vehicle (control group) or PAI-1 inhibitor (PAI-039 group). Endometriotic lesion size generated in recipient mice was monitored by mCherry signal. Animals were euthanized 21 d…
The Inflammatory Feed-Forward Loop Triggered by the Complement Component C3 as a Potential Target in Endometriosis
2021
Copyright © 2021 Agostinis, Zorzet, Balduit, Zito, Mangogna, Macor, Romano, Toffoli, Belmonte, Morello, Martorana, Borelli, Ricci, Kishore and Bulla. The complement system is a major component of humoral innate immunity, acting as a first line of defense against microbes via opsonization and lysis of pathogens. However, novel roles of the complement system in inflammatory and immunological processes, including in cancer, are emerging. Endometriosis (EM), a benign disease characterized by ectopic endometrial implants, shows certain unique features of cancer, such as the capacity to invade surrounding tissues, and in severe cases, metastatic properties. A defective immune surveillance against…
Validity of a novel device for indoor analysis of cyclists' drag area
2021
Cyclists need to measure aerodynamic resistance accurately and reliably, as well as economically. Devices such as Notio Aerostick, an equipment device that includes one pitot tube, have appeared for this purpose. The aim of this study is, therefore, to test the reliability and degree of agreement in the evaluation of the CdA (coefficient of aerodynamic drag), assessed by means of the Notio Aerostick compared to the Virtual Elevation (VE) and Martin mathematical models.Seventeen professional cyclists rode in a 250-metre-long velodrome covered with a concrete surface with their own time trial bikes. Each cyclist completed three rides of 15 laps at constant speed for the evaluation of the CdA,…
A Strategy for the Prediction of the Response of Hysteretic Systems: A Base for Capacity Assessment of Buildings under Seismic Load
2014
A statistical non linearization method is used to approximate systems modeled by the Bouc differential equa- tion and excited by a Gaussian white noise external load. To this aim restricted potential models (RPM) are used, which are suitable for an extended number of nonlinear problems as have been proved several times. Since the solution of RPM is known by the probabilistic point of view, all statistical characteristics can be derived at once with advantages by the computational point of view. Hence, this paper discusses the possibility to determine sets of parameters characterizing po- tential models that are valid for describing a hysteretic behavior. In this way the characterization of …
Environmental Management Maturity: The Role of Dynamic Validation.
2021
Maturity models enhance the performance of companies by prescribing a trajectory through stages of increasing capability. However, a recent review of maturity models concludes that current maturity models hardly meet the design principles required for prescriptive use. To address this deficiency, we conducted semistructured interviews and a Group Model Building study with industrial companies in Spain in which we studied the progression toward a Leading Green Company as the highest maturity stage of environmental management. The findings from the study were tested using surveys with enterprises in Spain, Italy, and the United Kingdom, semistructured interviews in the United Kingdom and case…
Comparing the Climatic and Landscape Risk Factors for Lyme Disease Cases in the Upper Midwest and Northeast United States
2020
Lyme disease, recognized as one of the most important vector-borne diseases worldwide, has been increasing in incidence and spatial extend in United States. In the Northeast and Upper Midwest, Lyme disease is transmitted by Ixodes scapularis. Currently, many studies have been conducted to identify factors influencing Lyme disease risk in the Northeast, however, relatively few studies focused on the Upper Midwest. In this study, we explored and compared the climatic and landscape factors that shape the spatial patterns of human Lyme cases in these two regions, using the generalized linear mixed models. Our results showed that climatic variables generally had opposite correlations with Lyme d…
Revista electrónica de investigación y evaluación educativa
2014
Resumen tomado de la publicación Título, resumen y palabras clave en inglés y español Se muestra que cuando se quiere conocer el grado de satisfacción del alumno con la docencia recibida, es aconsejable introducir en su análisis y estudio componentes contextuales. Las variables contextuales que se incluyen en el análisis están relacionadas con determinadas estructuras académicas de carácter organizativo. Estas estructuras son de tipo jerárquico o anidado y aportan información sobre datos como el tipo de estudios que el alumno realiza o la clase en la que el alumno está matriculado. Para obtener el nivel de satisfacción del alumnado se utilizan los cuestionarios de evaluación docente de la U…
Is clinical experience important for obtaining the primary stability of dental implants with aggressive threads? An ex vivo study
2018
GECKILI, ONUR/0000-0002-7852-3915; dayan, suleyman cagatay/0000-0003-3081-9618; Bilhan, Hakan/0000-0003-1787-3003 WOS:000460131200015 PubMed ID: 30818319 Background: The aim of this study was to investigate the clinicians' experience on maintaining the primary stability of implants with aggressive threads belonging to a novel dental implant system. Material and Methods: Three hundred implants with aggressive threads were inserted in fresh bovine ribs mimicking Type IV bone by five clinicians which were classified according to their previous experience of total number of implant insertion. An independent examiner measured the primary stability of all implants after insertion by using resonan…
INDUSTRY 4.0 AS SMART ENABLER FOR INNOVATIVE BUSINESS MODELS
2017
Master's thesis Business Administration BE501 - University of Agder 2017 Industry 4.0 is the upcoming 4th revolution within industrial setups across the world, mainly in manufacturing hubs. Industrial internet of Things (IIOT) will alter the dimensions of the way businesses used to be conducted and the way value was assessed and retrieved. IIOT tends to have a critical impact on the business models (BM) within various industrial sectors, either manufacturing or services. This study tries to observe IIOT related effects on the business models in regards to manufacturing industry from a Tech-based consultancy point of view. This study employs exploratory multiple case study approach to the to…