Search results for " Models"
showing 10 items of 4240 documents
Climate and extreme rainfall events in the Mono river basin (West Africa): investigating future changes with Regional Climate Models.
2020
This study characterizes the future changes in extreme rainfall and air temperature in the Mono river basin where the main economic activity is weather dependent and local populations are highly vulnerable to natural hazards, including flood inundations. Daily precipitation and temperature from observational datasets and Regional Climate Models (RCMs) output from REMO, RegCM, HadRM3, and RCA were used to analyze climatic variations in space and time, and fit a GEV model to investigate the extreme rainfalls and their return periods. The results indicate that the realism of the simulated climate in this domain is mainly controlled by the choice of the RCMs. These RCMs projected a 1 to 1.5 °
Comparative Analyses between the Zero-Inertia and Fully Dynamic Models of the Shallow Water Equations for Unsteady Overland Flow Propagation
2018
The shallow water equations are a mathematical tool widely applied for the simulation of flow routing in rivers and floodplains, as well as for flood inundation mapping. The interest of many researchers has been focused on the study of simplified forms of the original set of equations. One of the most commonly applied simplifications consists of neglecting the inertial terms. The effects of such a choice on the outputs of the simulations of flooding events are controversial and are an important topic of debate. In the present paper, two numerical models recently proposed for the solution of the complete and zero-inertia forms of the shallow water equations, are applied to several unsteady f…
Pathogenic Role of Complement in Antiphospholipid Syndrome and Therapeutic Implications
2018
Antiphospholipid syndrome (APS) is an acquired autoimmune disease characterized by thromboembolic events, pregnancy morbidity, and the presence of antiphospholipid (aPL) antibodies. There is sound evidence that aPL act as pathogenic autoantibodies being responsible for vascular clots and miscarriages. However, the exact mechanisms involved in the clinical manifestations of the syndrome are still a matter of investigation. In particular, while vascular thrombosis is apparently not associated with inflammation, the pathogenesis of miscarriages can be explained only in part by the aPL-mediated hypercoagulable state and additional non-thrombotic effects, including placental inflammation, have b…
Baseline Gut Microbiota Composition Is Associated With Schistosoma mansoni Infection Burden in Rodent Models
2020
In spite of growing evidence supporting the occurrence of complex interactions between Schistosoma and gut bacteria in mice and humans, no data is yet available on whether worm-mediated changes in microbiota composition are dependent on the baseline gut microbial profile of the vertebrate host. In addition, the impact of such changes on the susceptibility to, and pathophysiology of, schistosomiasis remains largely unexplored. In this study, mice colonized with gut microbial populations from a human donor (HMA mice), as well as microbiota-wild type (WT) animals, were infected with Schistosoma mansoni, and alterations of their gut microbial profiles at 50 days post-infection were compared to …
Are Toll-like receptors and decoy receptors involved in the immunopathogenesis of systemic lupus erythematosus and lupus-like syndromes?
2011
In this paper we focus our attention on the role of two families of receptors, Toll-like receptors (TLR) and decoy receptors (DcR) involved in the generation of systemic lupus erythematosus (SLE) and lupus-like syndromes in human and mouse models. To date, these molecules were described in several autoimmune disorders such as rheumatoid arthritis, antiphospholipids syndrome, bowel inflammation, and SLE. Here, we summarize the findings of recent investigations on TLR and DcR and their role in the immunopathogenesis of the SLE.
CD11b Regulates Fungal Outgrowth but Not Neutrophil Recruitment in a Mouse Model of Invasive Pulmonary Aspergillosis
2019
Abstract Background and Aims: In immunosuppressed individuals Aspergillus (A.) fumigatus is a frequent cause of invasive pulmonary aspergillosis (IPA) which is highly associated with relevant morbidity and mortality. Moreover, it often occurs in patients suffering from leukocyte-adhesion deficiency type 1 (LAD1) which is triggered by a functional loss of CD18 in ß2 integrin receptors as these receptors consist of an alpha subunit (CD11a-CD11d) and CD18 as the common beta subunit. ß2 integrin receptors are differentially expressed by leukocytes, and are required for cell-cell interaction, transendothelial migration, uptake of opsonized pathogens, and cell signaling processes. Here, we asked …
Modelos de organización política de la UMMA en la historia del pensamiento islámico
2011
ResumenEn el presente artículo, se estudian los modelos más representativos de organización política de la comunidad islámica o Umma en la historia del pensamiento islámico. Como introducción al tema, se analiza el papel central que ocupa el concepto de Umma como eje vertebrador de las relaciones entre religión y política en el Islam. Posteriormente, se exponen las principales posiciones acerca del gobierno de la Umma, desde los tiempos del Profeta hasta la actualidad. Por último, se propone la necesidad de desarrollar una completa y sistemática teoría sobre el modelo de organización política más acorde con una concepción democrática de la Umma.Abstract In this work the most representative …
Finnish Secondary Students’ Mental Models of Magnetism
2020
We examined Finnish lower secondary students’ mental models of magnetism through their drawings, written explanations and interviews. Secondary students in Finland (N=12) engaged in six lessons designed specifically to target three key concepts in understanding magnetism: structure and organization (magnetic domains), magnetic fields and magnetic interactions. We describe how, with a finite number of key concepts introduced, students reflected upon and revised their mental models of magnetism and magnetic interactions towards more sophisticated and normative scientific views. We found two new categories of students’ models: the pole model and pole/field model. The critical moments in evolvi…
Models de traducció literària i audiovisual en català col·loquial: el cas de «Jackie Brown» de Quentin Tarantino
2015
Aquest article tracta dels models de traducció col·loquial cap al català en el cas de la versió doblada (1997), la versió subtitulada (1997) i el guió traduït (1998) de Jackie Brown (1997) de Quentin Tarantino. El nucli de l’article és l’anàlisi i la comparació de la fonètica, la morfologia, la sintaxi i el lèxic de cada traducció catalana, que s’emmarca en els models lingüístics i de traducció vigents en el període objecte d’estudi. La conclusió a la qual s’arriba és que les tres traduccions utilitzen models de llengua col·loquial diferents. El guió traduït basteix un model trencador, sobretot en qüestions de representació fonètica i en el lèxic castellà que utilitza. La versió doblada s’a…
Evolucionismo, integración sociocognitiva y cambio semántico
2014
El cambio es el fenómeno lingüístico por excelencia a la hora de aplicar los modelos teóricos evolucionistas. La perspectiva evolucionista del lenguaje permite analizar el cambio lingüístico como un fenómeno sujeto a los mismos procesos evolutivos que determinan cualquier sistema evolutivo complejo. El objetivo de este estudio es defender una integración más sistemática de los factores sociales y cognitivos del cambio lingüístico, en particular del cambio semántico. Este artículo se centra en un enfoque evolutivo del cambio lingüístico muy influyente, la Teoría de la Selección del Enunciado del cambio lingüístico desarrollada por Croft (2000). El enfoque evolutivo de Croft se inspira en la …