Search results for " Models"
showing 10 items of 4240 documents
Cap a una cronologia dels models teatrals de Pedrolo
2015
This article scans Pedrolo's dramatic oeuvre starting from the comparative analysis of story-line and thematic aspects, characters, space and time. The final ambition is to emphasize the fact that three periods may be defined: early theatrical experiments (1954-1956), central production (1957-1963) and the last plays (1966-1977), that respond to different theatrical models.
Progenitor death drives retinal dysplasia and neuronal degeneration in a mouse model of Atrip-Seckel syndrome
2020
ABSTRACT Seckel syndrome is a type of microcephalic primordial dwarfism (MPD) that is characterized by growth retardation and neurodevelopmental defects, including reports of retinopathy. Mutations in key mediators of the replication stress response, the mutually dependent partners ATR and ATRIP, are among the known causes of Seckel syndrome. However, it remains unclear how their deficiency disrupts the development and function of the central nervous system (CNS). Here, we investigated the cellular and molecular consequences of ATRIP deficiency in different cell populations of the developing murine neural retina. We discovered that conditional inactivation of Atrip in photoreceptor neurons …
Increased autophagy and apoptosis contribute to muscle atrophy in a myotonic dystrophy type 1 Drosophila model
2015
ABSTRACT Muscle mass wasting is one of the most debilitating symptoms of myotonic dystrophy type 1 (DM1) disease, ultimately leading to immobility, respiratory defects, dysarthria, dysphagia and death in advanced stages of the disease. In order to study the molecular mechanisms leading to the degenerative loss of adult muscle tissue in DM1, we generated an inducible Drosophila model of expanded CTG trinucleotide repeat toxicity that resembles an adult-onset form of the disease. Heat-shock induced expression of 480 CUG repeats in adult flies resulted in a reduction in the area of the indirect flight muscles. In these model flies, reduction of muscle area was concomitant with increased apopto…
Mismatch negativity (MMN) in freely-moving rats with several experimental controls.
2014
Mismatch negativity (MMN) is a scalp-recorded electrical potential that occurs in humans in response to an auditory stimulus that defies previously established patterns of regularity. MMN amplitude is reduced in people with schizophrenia. In this study, we aimed to develop a robust and replicable rat model of MMN, as a platform for a more thorough understanding of the neurobiology underlying MMN. One of the major concerns for animal models of MMN is whether the rodent brain is capable of producing a human-like MMN, which is not a consequence of neural adaptation to repetitive stimuli. We therefore tested several methods that have been used to control for adaptation and differential exogenou…
The life of relationship in globalized financial economic devices: Evidences from the experience of a group-analytic transcultural workshop
2014
The present contribution - starting from the experience of the EATGA Workshop 2011 that took place in Palermo and that had as its theme “Intersubjective bonds in the globalized economy” - invites to reflect on the quality of the life of relationship and intersubjective connectedness in social contemporary world. One of the characterizing cultural phenomena influencing contemporary reality is made up by the dominant and pervasive presence of logic and language of financial markets in policies and activities that organize and articulate daily life. Theoretical hypothesis driving our research is that the structures of subjectivity, the meaning and the way of being in a relationship are charact…
DIRITTO ROMANO E DIRITTO CIVILE: LE RAGIONI DI UNA RINNOVATA RIFLESSIONE STORICA SUI MODELLI TEORICI E METODOLOGICI. A PROPOSITO DEL VOLUME DI GUIDO …
2021
The article investigates the relationship between Roman law, legal Tradition and modern civil law. The focus is mainly on theoretical and methodological models in the history of private law. In evaluating the history of the institutions, categories and concepts of civil law, the awareness is renewed that modern Codes are profoundly linked to ancient Tradition, and at the same time, represent the instrument of transmission of the same to subsequent eras. At the same time, it should be considered that even today's legal interpretation is deeply linked to Tradition, in content but above all in method. In this sense, it is then evident that carrying out an interpretation of private law in confo…
Lifetime measurements of lowest states in the π g7/2 ⊗ νh11/2 rotational band in 112I
2018
A differential-plunger device was used to measure the lifetimes of the lowest states in the πg7/2 ⊗ νh11/2 rotational band in doubly odd 112I with the 58Ni(58Ni, 3pn) reaction. A differential decay curve method was performed using the fully shifted and degraded γ -ray intensity measurements as a function of target-to-degrader distance. The lifetimes of the lowest three states in the πg7/2 ⊗ νh11/2 band in 112I were measured to be 124(30), 130(25), and 6.5(5) ps, respectively. As the lifetimes of successive excited states in a rotational band are expected to decrease with increasing excitation energy, these measurements suggest that the order of the transitions in the established band in 112…
Carsharing business models in Germany: characteristics, success and future prospects
2017
Carsharing provides an alternative to private car ownership by allowing car use temporarily on an on-demand basis. Operators provide carsharing services using different business models and ownership structures. We distinguish between cooperative, business-to-consumer (B2C) roundtrip and one-way, as well as peer-topeer (P2P) carsharing. This paper characterizes these different types of business models and compares their success in terms of diffusion using a comprehensive database of all 101 German carsharing providers in 2016. The key result holds that fleet size is significantly different across business models ranging from a few cars (cooperatives in small towns), to a few hundred (B2C rou…
Effectuation Logic in Digital Business Model Transformation : Insights from Japanese High-Tech Innovators
2019
Purpose The purpose of this paper is to study how digital business models evolve when entrepreneurs move to new digital platforms and how this evolution is related to effectuation and causation logics. Design/methodology/approach This study applies a multiple case study approach to investigate how digital business models change in small, Japanese high-tech firms providing their innovations through different digital platforms. To investigate digital business models, this study considers the elements that comprise general business models. The case firms were selected based on size, products and transitions from physical to various digital platforms. Semi-structured interviews were conducted …
Business Models and Market Entry Mode Choice of Small Software Firms
2007
So far the critical choice of the entry mode for a target country has been examined ignoring the special features of firms. Particularly, the impact of the wide variation of business models of software firms has been ignored. This multi-case study investigates the relation between the business model and the entry mode of eight software firms. The results imply that the product strategy and the service and implementation model of a software firm are closely connected to the entry mode choice, while the distribution model of intangible software products does not seem to have impact on the operation mode. peerReviewed