Search results for " Modification"
showing 10 items of 781 documents
Carbohydrate-Based Nanocarriers Exhibiting Specific Cell Targeting with Minimum Influence from the Protein Corona.
2015
Whenever nanoparticles encounter biological fluids like blood, proteins adsorb on their surface and form a so-called protein corona. Although its importance is widely accepted, information on the influence of surface functionalization of nanocarriers on the protein corona is still sparse, especially concerning how the functionalization of PEGylated nanocarriers with targeting agents will affect protein corona formation and how the protein corona may in turn influence the targeting effect. Herein, hydroxyethyl starch nanocarriers (HES-NCs) were prepared, PEGylated, and modified on the outer PEG layer with mannose to target dendritic cells (DCs). Their interaction with human plasma was then s…
Characterization of the epigenetic modifications in human uterine leiomyomas and evaluation of their potential as therapeutic targets in vitro
2023
Los miomas o fibromas uterinos (UL) son los tumores benignos más frecuentes en las mujeres en edad reproductiva. A pesar de su elevada prevalencia y de las diferentes opciones de tratamiento, no existe terapia eficaz para la reducción del tamaño de los UL que sea mínimamente invasiva y sin efectos secundarios a largo plazo. Su patología tumoral permanece desconocida, lo que dificulta el desarrollo de tratamientos seguros y eficaces. Por lo tanto, la identificación de los mecanismos moleculares implicados en la generación de UL podría permitir el desarrollo de tratamientos más eficaces. Las modificaciones epigenéticas están implicadas en el desarrollo de los tumores y pueden revertirse media…
Estimates for the Differences of Certain Positive Linear Operators
2020
The present paper deals with estimates for differences of certain positive linear operators defined on bounded or unbounded intervals. Our approach involves Baskakov type operators, the kth order Kantorovich modification of the Baskakov operators, the discrete operators associated with Baskakov operators, Meyer&ndash
Biomimetic strategy towards gelatin coatings on PET. Effect of protocol on coating stability and cell-interactive properties
2019
Gelatin-modified poly(ethylene terephthalate) (PET) surfaces have been previously realized via an intermediate dopamine coating procedure that resulted in surfaces with superior haemocompatibility compared to unfunctionalized PET. The present study addresses the biocompatibility assessment of these coated PET surfaces. In this context, the stability of the gelatin coating upon exposure to physiological conditions and its cell-interactive properties were investigated. The proposed gelatin–dopamine-PET surfaces showed an increased protein coating stability up to 24 days and promoted the attachment and spreading of both endothelial cells (ECs) and smooth muscle cells (SMCs). In parallel, physi…
Striving for mutual understanding : native English speakers' views on speech modifications in intercultural encounters
2016
”Foreigner talk” -nimistä ilmiötä on aikaisemmin tutkittu melko laajaltikin eri näkökulmien kautta. Suurin osa tutkimuksesta on tehty 1980-luvulla, jonka jälkeen termin käyttö näyttää hiljalleen vähentyneen. ”Foreigner talk” tarkoittaa muokattua kieltä, jonka tarkoitus on tehdä puheesta ymmärrettävämpää henkilölle, jonka kompetenssi kohdekielessä ei ole toisen puhujan kanssa syystä tai toisesta samalla tasolla: kyseessä voivat olla esimerkiksi kieltä äidinkielenään puhuva henkilö ja kieltä vieraana kielenä puhuva henkilö. Aivan viime aikoina ilmiö näyttää nouseen taas suosioon tutkimuskohteena etenkin osana työympäristöä, jossa kansainväliset kohtaamiset ovat monelle arkipäivää. Siitä huoli…
Cholesterol-Streptolysin O Interaction: An EM Study of Wild-Type and Mutant Streptolysin O
1998
We present transmission electron microscopical data from negatively stained specimens of cholesterol following interaction with the thiol-activated bacterial toxin streptolysin O (SLO) (wild-type and a number of cysteine substitution mutants), with and without chemical modification of the cysteine residues. Two experimental systems were used, one with an aqueous suspension of cholesterol microcrystals and the other with immobilized thin planar cholesterol crystals attached to a carbon film. In both systems the wild-type SLO and two cytolytically active mutants, Cys 530 --Ala (C530A) and Ser 101 --Cys (S101C), readily generated the characteristic SLO arc- and ring-like oligomers on the surfa…
Covalently modified halloysite clay nanotubes: synthesis, properties, biological and medical applications
2017
Halloysite (HNT) is a promising natural nanosized tubular clay mineral that has many important uses in different industrial fields. It is naturally occurring, biocompatible, and available in thousands of tons at low cost. As a consequence of a hollow cavity, HNT is mainly used as nanocontainer for the controlled release of several chemicals. Chemical modification of both surfaces (inner lumen and outer surface) is a strategy to tune the nanotube's properties. Specifically, chemical modification of HNT surfaces generates a nanoarchitecture with targeted affinity through outer surface functionalization and drug transport ability from functionalization of the nanotube lumen. The primary focus …
A NEW ROUTE TO OBTAIN PANI-EAA FLEXIBLE FILMS
2010
Tarkkaavaisuushäiriöiden helpottaminen koulun keinoin : neljä esimerkkiä behavioraalisen intervention toteuttamisesta
2002
Ni@Fe2O3 heterodimers: controlled synthesis and magnetically recyclable catalytic application for dehalogenation reactions
2012
Ni@Fe2O3 heterodimer nanoparticles (NPs) were synthesized by thermal decomposition of organometallic reactants. After functionalization, these Ni@Fe2O3 heterodimers became water soluble. The pristine heterodimeric NPs were characterized by transmission electron microscopy (TEM), X-ray diffraction (XRD), Mossbauer spectroscopy and magnetic susceptibility measurements. A special advantage of the heterodimers lies in the fact that nanodomains of different composition can be used as catalysts for the removal of environmentally hazardous halogenated pollutants.