Search results for " Modification"
showing 10 items of 781 documents
Synthesis and preliminary in vivo evaluation of well-dispersed biomimetic nanocrystalline apatites labeled with positron emission tomographic imaging…
2015
In recent years, biomimetic synthetic apatite nanoparticles (AP-NPs), having chemical similarity with the mineral phase of bone, have attracted a great interest in nanomedicine as potential drug carriers. To evaluate the therapeutic perspectives of AP-NPs through the mechanisms of action and organs they interact with, the noninvasive monitoring of their in vivo behavior is of paramount importance. To this aim, here the feasibility to radiolabel AP-NPs ("naked" and surface-modified with citrate to reduce their aggregation) with two positron emission tomographic (PET) imaging agents ([F-18]NaF and Ga-68-NO(2)AP(BP)) was investigated. [F-18]NaF was used for the direct incorporation of the radi…
Synthesis and Characterisation of Functionalized borosilicate nanoparticles for boron neutron capture therapy applications
2012
Boron Neutron Capture Therapy (BNCT) is a promising therapy for the cure of diffuse tumors. The successful clinical application of BNCT requires finding new boron-based compounds suitable for an efficient 10B delivery to the cancerous tissues. The purpose of this work is to synthesize borosilicate nanoparticles by a sol–gel recipe, and to functionalize them with folic acid in order to promote their capture by the tumor cells. Whereas sol–gel is a promising technique for the synthesis of nanoparticles, in case of borosilicate systems this approach is affected by significant boron loss during preparation. Here we show that functionalization of borosilicate nanoparticles with folic acid can re…
Fluorination of some highly functionalized cycloalkanes: chemoselectivity and substrate dependence.
2017
A study exploring the chemical behavior of some dihydroxylated β-amino ester stereo- and regioisomers, derived from unsaturated cyclic β-amino acids is described. The nucleophilic fluorinations involving hydroxy–fluorine exchange of some highly functionalized alicyclic diol derivatives have been carried out in view of selective fluorination, investigating substrate dependence, neighboring group assistance and chemodifferentiation.
Jet shape modification in Pb-Pb collisions at √S[sub]N[sub]N= 2.76 TeV using two-particle correlations
2018
This thesis focuses on two separate topics. The first topic concerns the upgrade of the Time Projection Chamber (TPC) detector of the ALICE experiment. The upgrade will take place during the second Long Shutdown (2019-2020). The part of the upgrade I participated in was the replacement of the detector’s current readout electronics with Gas Electron Multiplier (GEM) foils. This change would allow for the continuous readout of the data, resulting in a hundredfold increase in the amount of data the ALICE experiment can process, as the TPC is the central tracking detector. I was involved in the Quality Assurance (QA) of these GEM foils. The advanced QA procedure consists of three measurements, a…
Deterministic Modification of CVD Grown Monolayer MoS2 with Optical Pulses
2021
| openaire: EC/H2020/820423/EU//S2QUIP | openaire: EC/H2020/834742/EU//ATOP Transition metal dichalcogenide monolayers have demonstrated a number of exquisite optical and electrical properties. Here, the authors report the optical modification of topographical and optical properties of monolayer MoS2 with femtosecond pulses under an inert atmosphere. A formation of three-dimensional structures on monolayer MoS2 with tunable height up to ≈20 nm is demonstrated. In contrast to unmodified monolayer MoS2, these optically modified structures show significantly different optical properties, such as lower photoluminescence intensity and longer fluorescence lifetime. The results suggest a novel way…
Dictamen profesional sobre la fusión y escisión como extrategias alternativas en un grupo de sociedades
2021
This work is a professional, legal opinion which sets out two alternative strategies (merger by absorption and partial demerger) in order to bring together the different areas of activity of the various companies in a group of companies. The aim is to provide solutions to the questions raised by customers and, therefore, to set out clearly and simply the procedure to be followed in each of the strategies, weighing up the advantages and disadvantages from each of them
The Use of Question Modification Strategies to Differentiate Instruction in Eritrean Mathematics and Science Classrooms
2023
This qualitative study aimed at examining the question modification strategies Eritrean elementary and middle school teachers used to differentiate their instruction and meet the diversity in the classroom as well as the functions these strategies served in classroom interactions. The research data consisted of videotaped recordings (N = 11 videotaped lessons) of classroom interactions in eight mathematics and science classrooms, which were analysed through interaction analysis. The findings showed that Eritrean teachers utilised the following five question modification strategies either independently or in combination: repetition; rephrasing; clarification; decomposition; and code-switchin…
Data from: Climate determinants of breeding and wintering ranges of lesser kestrels in Italy and predicted impacts of climate change
2017
Climate warming would theoretically create conditions for the breeding range expansion of pseudo-steppe Mediterranean and long-distance migrant species and provide the possibility for these to overwinter in the same breeding areas. However, contemporary changes in rainfall regimes might have negative effects on the climate suitability and in turn, shrink species potential range. The lesser kestrel Falco naumanni is highly sensitive to rainfall oscillations and has recently extended its Italian breeding range towards northern latitudes and increasing its wintering records. We modelled the effects of temperature and rainfall on current and future climate suitability for lesser kestrels in bot…
Mesoporous Silica-Based Materials with Bactericidal Properties
2019
[EN] Bacterial infections are the main cause of chronic infections and even mortality. In fact, due to extensive use of antibiotics and, then, emergence of antibiotic resistance, treatment of such infections by conventional antibiotics has become a major concern worldwide. One of the promising strategies to treat infection diseases is the use of nanomaterials. Among them, mesoporous silica materials (MSMs) have attracted burgeoning attention due to high surface area, tunable pore/particle size, and easy surface functionalization. This review discusses how one can exploit capacities of MSMs to design and fabricate multifunctional/controllable drug delivery systems (DDSs) to combat bacterial …
Diabetes: Psychosocial Aspects
2015
This article is a revision of the previous edition article by K. Chamberlain, volume 6, pp. 3628–3631, © 2001, Elsevier Ltd.