Search results for " Modulation"

showing 10 items of 496 documents

Wharton's Jelly Mesenchymal Stem Cells and Immune Modulation: Regenerative Medicine Meets Tissue Repair

2013

Settore BIO/16 - Anatomia UmanaMesenchymal stem cellImmunologyWharton's jellyBiologyTissue repairImmune modulationRegenerative medicineWharton's jelly umbilical cord mesenchymal stem cells regenerative medicine immune modulation tissue repair differentiationCell biology
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Isolation and phenotypical characterization of mesenchymal stem cells from the Wharton's jelly of pre-term human umbilical cord

2014

Settore BIO/16 - Anatomia UmanaUmbilical cord perinatal stem cells mesenchymal stem cells immune modulation isolation protocol cell culture markers
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Wharton’s jelly mesenchymal stem cells: differentiative potency, immune modulation and the role of B7-H3

2014

Settore BIO/16 - Anatomia UmanaWJ-MSCs B7-H3 immune modulation cord blood
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Characterization of the immunomodulatory properties of mesenchymal stem cells isolated from Wharton's jelly

2012

Settore BIO/16 - Anatomia UmanaWharton's jelly umbilical cord mesenchymal stem cells immune modulation regenerative medicine differentiation
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Non-classical type I HLAs and B7 costimulators revisited: analysis of expression and immunomodulatory role in undifferentiated and differentiated MSC…

2011

Introduction. Wharton’s jelly (WJ), the main constituent of umbilical cord, emerged as a reliable and uncontroversial source of mesenchymal stem cells (MSC). WJ-MSC show unique ability in crossing lineage borders, therefore being capable to trans-ifferentiate towards mature cytotypes derived from the three germ layers. As other fetal-associated cells, WJ-MSC express several immunomodulatory molecules, essential during the initial phases of human development and for the processes linked to the tolerance of the mother to the semiallogeneic embryo. Very few data are present in literature on the maintenance of the immune privilege of the naïve cells after performing differentiation. Our previou…

Settore BIO/16 - Anatomia Umanamesenchymal stem cells umbilical cord Wharton's jelly immune modulation hepatocyte differentiation
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New frontiers in regenerative medicine in cardiology: the potential of Wharton's jelly mesenchymal stem cells.

2013

Cardiomyopathies are still the first cause of death in the world. The identification of resident stem cells, comprising those derived from sub-endocardial stroma, suggests the possible self regeneration of the heart under autocrine/paracrine modulation in the cardiac microenvironment. Nevertheless, because of the limited in vivo regeneration potential of damaged cardiac tissue, the use of drugs and ultimately cardiac transplantation remain the common treatments of heart diseases and defects. The differentiative potential of embryonic and mesenchymal stem cells (MSCs) derived from different tissues (such as bone marrow and adipose tissue) was extensively explored in cell therapy for regenera…

Settore BIO/17 - IstologiaImmune modulationCardiologyMedicine (miscellaneous)Clinical uses of mesenchymal stem cellsHeart failureBiologyRegenerative MedicineRegenerative medicineWharton's jellyHumansWharton JellyTissue repairMesenchymal stem cellStem cell transplantation for articular cartilage repairSettore BIO/16 - Anatomia UmanaWharton's jellyRegeneration (biology)Mesenchymal stem cellMesenchymal Stem CellsGeneral MedicineHeart failure; Immune modulation; Mesenchymal stem cells; Regenerative medicine; Tissue repair; Wharton's jellyTransplantationCardiovascular DiseasesImmunologyCancer researchStem cell
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Umbilical Cord Mesenchymal Stromal Cells for Cartilage Regeneration Applications

2022

Chondropathies are increasing worldwide, but effective treatments are currently lacking. Mesenchymal stromal cell (MSCs) transplantation represents a promising approach to counteract the degenerative and inflammatory environment characterizing those pathologies, such as osteoarthritis (OA) and rheumatoid arthritis (RA). Umbilical cord- (UC-) MSCs gained increasing interest due to their multilineage differentiation potential, immunomodulatory, and anti-inflammatory properties as well as higher proliferation rates, abundant supply along with no risks for the donor compared to adult MSCs. In addition, UC-MSCs are physiologically adapted to survive in an ischemic and nutrient-poor environment a…

Settore BIO/17 - IstologiaReview ArticleCell Biologymesenchymal stromal cells stem cells cartilage regenerative medicien tissue engineering immune modulationMolecular BiologyInternal medicineRC31-1245Stem Cells International
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The Immunomodulatory Features of Mesenchymal Stromal Cells Derived from Wharton’s Jelly, Amniotic Membrane, and Chorionic Villi In Vitro and In Vivo …

2016

This chapter focuses on the immunomodulatory properties of placental mesenchymal stromal cells (MSCs) derived from the amniotic membrane, umbilical cord, and chorionic villi. Within the amniotic membrane (AM), we discuss the immunomodulatory properties of the two main cell populations that can be isolated from AM: human amniotic mesenchymal stromal cells (hAMSCs) and human amniotic epithelial cells (hAECs). Within the umbilical cord, several compartments have been described, including the amniotic compartment, the Wharton’s jelly (WJ) compartment, and the vascular and perivascular compartment, but herein attention is focused on the properties of human WJ MSCs (hWJMSCs). Since different isol…

Settore BIO/17 - IstologiaWharton’s JellyUmbilical cord Wharton's jelly placenta mesenchymal stromal cells stem cells chorionic villi amniotic membrane regenerative medicine differentiation immeune modulationSettore BIO/16 - Anatomia UmanaSettore BIO/13 - BIOLOGIA APPLICATA
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Rateless Codes Performance Analysis in Correlated Channel Model for GEO Free Space Optics Downlinks

2012

Settore ING-INF/03 - TelecomunicazioniFree Space Optics (FSO) technologies for satellite communications offer several advantages: wide bandwidth high rate capability immunity to electromagnetic interference and small equipment size. Thus they are suitable for inter-satellite links deep space communications and also for high data rate ground-to-satellite/satellite-to-ground communications. Nevertheless FSO links suffer impairments that cause power signal degradation at the receiver. Scattering and absorption cause power signal attenuations predictable by suitable deterministic models. Optical turbulence causes random irradiance fluctuations which can generate signal fading events and can thereby only be predicted by statistical models. Attenuation and fading events can corrupt FSO links and so it would be recommended to add mitigation error codes on the communication link. FSO channel can be described as an erasure channel: fading events can cause erasure errors. We have identified in rateless codes (RCs) a suitable solution to be employed in FSO links. RCs do not need feedback and they add a redundant coding on the source data that allows the receiver to recover the whole payload despite erasure errors. We implemented two different of rateless codes: Luby Transform (LT) and Raptor. We analyzed their performances on a simulated turbulent GEO FSO downlink (1 Gbps - OOK modulation) at a 106 μm wavelength and for different values of zenith angles. Assuming a plane-wave propagation and employing Hufnagel-Valley we modeled the downlink using: 1) a temporal correlated channel model based on Gamma-Gamma probability distribution and 2) an irradiance covariance function that we converted on a time function using Taylor frozen eddies hypothesis. Our new channel model is able to simulate irradiance fluctuations at different turbulence conditions as it will be shown in the full paper. We will also report performance results of LT and Raptor codes at overhead range varying between 0 and 50% and for different values of source packets.Settore ING-INF/01 - Elettronica
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Investigation on Cascode Devices for High Frequency Electrical Drives Applications

2019

In the last years a widespread development in the market of electrical drives employing high-speed electrical machines has occurred in various industrial fields, due to the extremely high power density that can be reached. Nevertheless, to maintain output power quality without using bulky filtering networks, DC-AC converters should be controlled by means of higher PWM switching frequencies. New switching device technologies, such as Field Effect Transistors based on SiC and GaN, are therefore gathering momentum in order to comply with the higher working frequencies. To operate under high frequencies and at the same time at high voltage levels, alternative circuital configurations for switch…

Settore ING-INF/05 - Sistemi Di Elaborazione Delle InformazioniMomentum (technical analysis)High voltage deviceComputer sciencebusiness.industry020209 energyCascode020208 electrical & electronic engineeringElectrical engineeringHigh voltage02 engineering and technologyConvertersSettore ING-IND/32 - Convertitori Macchine E Azionamenti ElettriciHigh frequencyPower transistors0202 electrical engineering electronic engineering information engineeringField-effect transistorPower semiconductor deviceCascodebusinessFrequency modulationPulse-width modulation
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