Search results for " Natural products"

Control of powdery mildew in cut roses using natural products in the greenhouse.

2009

Roses grown under greenhouse cultivation are commonly affected by diseases and regular fungicide applications are commonly used. The aim of this research was to identify natural products that can substitute and reduce the health and environmental impacts of typical chemical treatments in the control of powdery mildew [(Podosphaera pannosa (Wallr. Fr.) de Bary] and grey mould (Botrytis cinerea Pers.). Treatments were applied in the greenhouse on the cut rose cultivars Sunluck (Gold Strike®) and Nirpbredy (New Fashion®) growing in a soilless system. Oregano and clove essential oil at 0.5 ml/l (an emulsifier was added) and sodium bicarbonate (NaHCO3) at 4 g/l were sprayed on rose plants to run…

Discovery of plants and fungi with antibacterial activity against Propionibacterium acnes

2016

Acne vulgaris is a common skin disorder that affects >85% of teenagers. Propionibacterium acnes is implicated in its pathogenesis, and like many other bacteria, is subject to emerging trends in antibiotic resistance. Novel therapies are in high demand. The aim of this study was to identify new leads for future pre-clinical development from herbal skin remedies used in Italy. We screened a unique natural product library composed of extracts from medicinal and randomly collected plants and fungi from the Mediterranean for growth-inhibitory and anti-biofilm activity in P. acnes. Evaluation of 157 extracts from 10 fungi and 58 plants led to the identification of crude extracts from seven specie…

Effetti antiproliferativi degli estratti di emociti dell'ascidia Styela plicata ( Tunicata)

2009

Current Bioactive Azole-Containing Natural Products

2010

Cyclodextrins: heterocyclic molecules able to perform chiral recognition (Part II)

2006

The present paper collects the most significant advances appeared since late 1998 up to June 2005 in the field of applications of natural and modified cyclodextrins as chiral selectors, with particular regard for pharmaceuticals and natural products.

Anti-inflammatory activity in selected Antarctic benthic organisms

2014

Antarctic benthos was prospected in search for anti-inflammatory activity in polar benthic invertebrates, in two different geographical areas: deep-bottoms of the Eastern Weddell Sea and shallow-waters of the South Shetland Islands. A total of 36 benthic algae and invertebrate species were selected to perform solubility tests in order to obtain extracts that were soluble at an innocuous ethanol concentration (0.2%) for cell culture, and further test them for anti-inflammatory activity. From these, ethanol extracts of ten species from five different phyla resulted suitable to be studied in cell macrophage cultures (RAW 264.7). Cytotoxicity (MTT method) and production of inflammatory mediator…

Molecular Determinants of the Response of Tumor Cells to Boswellic Acids

2011

Frankincense (Boswellia serrata, B. carterii) is used as traditional remedy to treat inflammatory diseases. The molecular effects of the active ingredients, the boswellic acids, on the immune system have previously been studied and verified in several clinical studies. Boswellic acids also inhibit cancer cell growth in vitro and in vivo. The molecular basis of the cytotoxicity of boswellic acids is, however, not fully understood as yet. By mRNA-based microarray, COMPARE, and hierarchical cluster analyses, we identified a panel of genes from diverse functional groups, which were significantly associated with sensitivity or resistance of a- or b-boswellic acids, such as transcription factors,…

Editorial: Emerging heterocycles as bioactive compounds

2023

Heterocycles represent a privileged scaffold due to their ability to interact with biological systems via heteroatoms. It is no coincidence that every year the Food and Drug Administration approves numerous new drugs that contain at least one heterocyclic system as active pharmacophoric part in their structure. Many heterocyclic compounds with therapeutic properties, including anticancer, antimicrobial, anti-inflammatory and so on, come from natural sources such as plants and animals, and medicinal chemists very often use them to study their chemical space and improve their biological activity. In fact, several efficient approaches for the formation of aromatic heterocyclic compounds and th…

Synthetic Approaches to the Lamellarins—A Comprehensive Review

2014

The present review discusses the known synthetic routes to the lamellarin alkaloids published until 2014. It begins with syntheses of the structurally simpler type-II lamellarins and then focuses on the larger class of the 5,6-saturated and -unsaturated type-I lamellarins. The syntheses are grouped by the strategy employed for the assembly of the central pyrrole ring.

Antinociceptive Effects of Turkish Endemic Eryngium kotschyi Boiss. Roots by Bioactivity Guided Fractionation

2010

Eryngium species (Apiaceae) are well known plants in ethnobotanical culture throughout world and also in Turkey. They are used as antitussive, diuretic as well as for analgesic and antiinflammatory purposes in traditional medicine. This study aimed to evaluate the antinociceptive activity of endemic Eryngium kotschyi Boiss. root extracts by bioguided fractionation. The antinociceptive activity of the extracts/fractions/compound was studied in mice using acetic acid induced writhing test and and hot plate test. The methanolic extract was sequentially partitioned with hexane, dichloromethane and water saturated n-butanol. Among the fractions, the n-BuOH fraction showed the most significant re…