Search results for " Nervous System Disease"

showing 10 items of 244 documents

Central nervous system involvement at first relapse in patients with acute promyelocytic leukemia treated with all-trans retinoic acid and anthracycl…

2009

Background The prevalence of and risk factors for central nervous system recurrence in patients with acute promyelocytic leukemia are not well established and remain a controversial matter. Design and Methods Between 1996 and 2005, 739 patients with newly diagnosed acute promyelocytic leukemia enrolled in two consecutive trials (PETHEMA LPA96 and LPA99) received induction therapy-with all-trans retinoic acid and idarubicin. Consolidation therapy comprised three courses of anthracycline monochemotherapy (LPA96), with all-trans retinoic acid and reinforced doses of idarubicin in patients with an intermediate or high risk of relapse (LPA99). Central nervous system prophylaxis was not given. Re…

:Chemicals and Drugs::Organic Chemicals::Hydrocarbons::Hydrocarbons Cyclic::Hydrocarbons Aromatic::Polycyclic Hydrocarbons Aromatic::Naphthacenes::Anthracyclines::Daunorubicin::Idarubicin [Medical Subject Headings]:Diseases::Pathological Conditions Signs and Symptoms::Pathologic Processes::Disease Attributes::Recurrence [Medical Subject Headings]Male:Named Groups::Persons::Age Groups::Adult::Middle Aged [Medical Subject Headings]idarubicinGastroenterology:Analytical Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Epidemiologic Methods::Statistics as Topic::Probability::Risk::Risk Factors [Medical Subject Headings]:Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Primates::Haplorhini::Catarrhini::Hominidae::Humans [Medical Subject Headings]Central Nervous System NeoplasmsLeukemia Promyelocytic AcuteRecurrenceRisk FactorsCumulative incidenceAntibiotics AntineoplasticHematologyMiddle Agedall-trans retinoic acidLeukemiamedicine.anatomical_structure:Named Groups::Persons::Age Groups::Adolescent [Medical Subject Headings]Femalemedicine.drugAcute promyelocytic leukemiaAdultcentral nervous system relapsemedicine.medical_specialty:Diseases::Neoplasms::Neoplasms by Histologic Type::Leukemia::Leukemia Myeloid::Leukemia Myeloid Acute [Medical Subject Headings]AnthracyclineAdolescentCentral nervous system:Check Tags::Male [Medical Subject Headings]TretinoinNeoplasias del sistema nervioso centralCentral nervous system diseaseTretinoinInternal medicine:Named Groups::Persons::Age Groups::Adult [Medical Subject Headings]medicineIdarubicinHumans:Named Groups::Persons::Age Groups::Adult::Aged [Medical Subject Headings]Letters to the Editor:Chemicals and Drugs::Organic Chemicals::Hydrocarbons::Hydrocarbons Acyclic::Alkenes::Polyenes::Carotenoids::Retinoids [Medical Subject Headings]Leucemia promielocítica agudaAgedAntibióticos antineoplásicosbusiness.industryprognostic factors:Chemicals and Drugs::Chemical Actions and Uses::Pharmacologic Actions::Therapeutic Uses::Antineoplastic Agents::Antibiotics Antineoplastic [Medical Subject Headings]acute promyelocytic leukemiamedicine.diseaseSurgery:Diseases::Neoplasms::Neoplasms by Site::Nervous System Neoplasms::Central Nervous System Neoplasms [Medical Subject Headings]:Check Tags::Female [Medical Subject Headings]businessIdarubicin
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Brain tissue pO2 related to SjvO2, ICP, and CPP in severe brain injury

2000

The aim of this report is to present first experience in comparing the course of brain tissue oxygen pressure values (PtiO2) to changes in jugular vein oxygen saturation (SjvO2), intracranial pressure (ICP), and cerebral perfusion pressure (CPP) after severe brain injury. PtiO2 monitoring was done using a polarographic Clark type microcatheter (LICOX pO2 probe) (GMS, Kiel, Germany) with a diameter of 0.5 mm and a sensitive area 7.9 mm long inserted in a right frontal position. The microcatheter was connected to a LICOX pO2 device. A fiber-optic catheter was used to measure SjvO2 and placed into the right internal jugular vein. The ICP monitoring was performed with a fiber-optic intraparench…

AdultAdolescentIntracranial PressurePartial PressureCentral nervous systemBlood PressureCentral nervous system diseaseJugular veinHumansMedicineCerebral perfusion pressureMonitoring PhysiologicIntracranial pressureOxygen saturation (medicine)business.industryBrainGeneral MedicineOxygenationMiddle Agedmedicine.diseaseOxygenCathetermedicine.anatomical_structureBrain InjuriesCerebrovascular CirculationAnesthesiaSurgeryNeurology (clinical)Jugular VeinsTomography X-Ray ComputedbusinessNuclear medicineNeurosurgical Review
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PET Studies of Net Blood—Brain Clearance of FDOPA to Human Brain: Age-Dependent Decline of [18F]Fluorodopamine Storage Capacity

2005

Conventional methods for the graphical analysis of 6-[18F]fluorodopa (FDOPA)/positron emission tomography (PET) recordings ( Kappin) may be prone to negative bias because of oversubtraction of the precursor pool in the region of interest, and because of diffusion of decarboxylated FDOPA metabolites from the brain. These effects may reduce the sensitivity of FDOPA/PET for the detection of age-related changes in dopamine innervations. To test for these biasing effects, we have used a constrained compartmental analysis to calculate the brain concentrations of the plasma metabolite 3- O-methyl-FDOPA (OMFD) during 120 mins of FDOPA circulation in healthy young, healthy elderly, and Parkinson's …

AdultAgingFluorine Radioisotopesmedicine.medical_specialtyMetaboliteDiffusionCentral nervous system diseasechemistry.chemical_compoundDopamineInternal medicinemedicineHumans18F-fluorodopamineFluorodopamedicine.diagnostic_testbusiness.industryPutamenBrainHuman brainMiddle Agedmedicine.diseaseDihydroxyphenylalanineEndocrinologymedicine.anatomical_structureNeurologychemistryPositron emission tomographyPositron-Emission TomographyNeurology (clinical)Cardiology and Cardiovascular MedicineNuclear medicinebusinessmedicine.drugJournal of Cerebral Blood Flow & Metabolism
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Age at menopause predicts age at onset of Parkinson's disease.

2006

We investigated the association between age at onset of Parkinson's disease (PD) and fertile life characteristics in 145 women. Linear regression analyses showed a significant correlation between age at PD onset and age at menopause (P = 0.003), between age at PD onset and fertile life duration (P = 0.008), and a nonsignificant correlation between PD onset and cumulative duration of pregnancies (P = 0.23). These results support the possible role of estrogens in PD.

AdultAgingmedicine.medical_specialtyParkinson's diseasePhysiologyDiseaseRisk AssessmentCentral nervous system diseaseDegenerative diseasefertile lifePregnancyRisk FactorsInternal medicineage at menopausemedicineHumansAge of OnsetRisk factorAgedAged 80 and overPregnancybusiness.industryParkinson DiseaseMiddle Agedmedicine.diseaseMenopauseEndocrinologyNeurologyParkinson’s diseaseLinear ModelsSettore MED/26 - NeurologiaFemalewomenNeurology (clinical)MenopauseAge of onsetbusiness
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How angioarchitecture of cerebral arteriovenous malformations should influence the therapeutic considerations.

1995

PURPOSE To evaluate the angioarchitectural criteria of complex cerebral arteriovenous malformations (AVMs), concerning the risk of hemorrhage and therapy planing. METHODS The magnetic resonance (MR) imaging and neuroangiographic findings of 227 AVMs (223 patients) were retrospectively evaluated. Statistical analysis was used to define the relative frequency of these lesions for hemorrhage in correlation with various parameters (i.e. age of the patient, size, location, associated aneurysms). RESULTS Onset of symptoms was between 21 and 40 years of age in 50% of cases. The ratio of centrally to convexially located lesions was 1:2. Convexial AVMs are classified by MR imaging into sulcal and gy…

AdultIntracranial Arteriovenous MalformationsMalemedicine.medical_specialtyAdolescentCentral nervous system diseaseRisk FactorsmedicineHumansIn patientStatistical analysisChildAgedCerebral HemorrhageRetrospective Studiesmedicine.diagnostic_testbusiness.industryVascular diseaseInfant NewbornInfantArteriovenous malformationMagnetic resonance imagingIntracranial AneurysmGeneral MedicineCerebral ArteriesMiddle Agedmedicine.diseaseMagnetic Resonance ImagingCerebral arteriovenous malformationsSurgeryCerebral AngiographyChild PreschoolAngiographySurgeryFemaleNeurology (clinical)RadiologybusinessMinimally invasive neurosurgery : MIN
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Stereotactically guided cavernous malformation surgery.

1996

The incidence of a significant hemorrhage in the natural history of cavernomas is below 1% per year, but the risk of a second hemorrhage in patients with initial bleeding cavernomas is between 14% and 29%. In the light of these figures, all cavernomas ought to be resected if surgical-related morbidity can be minimized. Stereotactically guided neurosurgery offers the advantage of planning the least traumatic approach before craniotomy due to the knowledge of the exact localisation of the lesion. During a 2-year period 12 patients (age 16-54 years) with intracranial supratentorial cavernomas (size 0.5-1.8 cm) were treated by stereotactically guided microsurgery. The cavernomas were seated in …

AdultIntracranial Arteriovenous MalformationsMalemedicine.medical_specialtyMicrosurgeryAdolescentmedicine.medical_treatmentAsymptomaticCentral nervous system diseaseStereotaxic TechniquesEpilepsyMedicineHumansCraniotomyCerebral Hemorrhagebusiness.industryBrain NeoplasmsGeneral MedicineMicrosurgeryMiddle Agedmedicine.diseaseSurgeryHemangioma CavernousHemosiderinSurgeryCavernous SinusFemaleNeurology (clinical)Neurosurgerymedicine.symptombusinessCorticotomyMinimally invasive neurosurgery : MIN
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Peripheral nerve involvement in chronic liver disease. Clinical and electrophysiological study.

1986

A clinical and electrophysiological study was carried out on 19 selected patients with chronic liver disease. Clinical signs of peripheral nerve involvement were found in 4 patients (21%); while electrophysiological impairment was present in 11 patients (57.8%). These abnormalities were mostly limited to the sensory and motor fibers of the tibialis posterior nerve. Our data confirm the presence of peripheral nerve involvement in chronic liver disease, and that it may be evidenced by careful electrophysiological examination.

AdultLiver CirrhosisMalemedicine.medical_specialtyPathologyNeurologyNeural ConductionSensory systemDermatologyChronic liver diseasePeripheral nervemedicineHumansNeuroradiologyAgedHepatitis Chronicbusiness.industryGeneral NeuroscienceLiver DiseasesPeripheral Nervous System DiseasesGeneral MedicineMiddle Agedmedicine.diseasePsychiatry and Mental healthElectrophysiologyToxic neuropathyChronic DiseaseFemaleNeurology (clinical)NeurosurgerybusinessItalian journal of neurological sciences
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Secondary tactile hypoesthesia: a novel type of pain-induced somatosensory plasticity in human subjects

2004

Quantitative sensory testing revealed that pain induced by intracutaneous capsaicin injection elicited secondary hyperalgesia coexisting with secondary tactile hypoesthesia. Mapping the areas of altered mechanical sensations adjacent to the capsaicin injection disclosed that the area of secondary hyperalgesia was always nested in a larger area of secondary hypoesthesia easily detected as numbness by most subjects. Psychometric functions revealed a twofold rightward shift of tactile detection (hypoesthesia), which coexisted with a more than fourfold leftward shift of pricking pain detection (hyperalgesia) in the same skin area. As a mechanism we propose a functional switch at the spinal leve…

AdultMaleAdolescentPresynaptic TerminalsPainNeurological disorderSomatosensory systemSynaptic TransmissionHypesthesiachemistry.chemical_compoundmedicineHumansNeurons AfferentSkinAfferent PathwaysNerve Fibers UnmyelinatedNeuronal PlasticityGeneral NeuroscienceNociceptorsPeripheral Nervous System DiseasesNeural InhibitionHypoesthesiaMiddle Agedmedicine.diseaseMechanoreceptorNociceptionmedicine.anatomical_structurechemistryTouchCapsaicinAnesthesiaHyperalgesiaNociceptorFemaleCapsaicinmedicine.symptomPsychologyMechanoreceptorsNeuroscienceNeuroscience Letters
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Prevalence of Apolipoprotein E Alleles in Healthy Subjects and Survivors of Ischemic Stroke

1998

Background and Purpose —The ε4 allele of the apolipoprotein E (apoE) has been related to the occurrence of myocardial infarction, but its association with ischemic stroke is controversial. We have evaluated the relation between apoE alleles and the occurrence of cerebrovascular ischemia. Methods —The apoE ε genotypes of 100 patients with a documented history of ischemic stroke without clinically apparent dementia (stroke+) and 108 subjects without such history (stroke−) were determined. The relative frequency of the apoE alleles and genotypes was estimated in 398 healthy subjects aged <40 years from the same ethnic background. Results —The frequency of the apoE ε4 allele in stroke+ (0.1…

AdultMaleApolipoprotein Emedicine.medical_specialtyGastroenterologyBrain IschemiaCentral nervous system diseaseApolipoproteins EReference ValuesRisk FactorsInternal medicineOdds RatiomedicineHumansSurvivorsMyocardial infarctionRisk factorAlleleStrokeAllelesAgedAged 80 and overAdvanced and Specialized Nursingbusiness.industryDementia VascularHomozygoteCase-control studyMiddle Agedmedicine.diseaseThrombosisSurgeryItalyCase-Control StudiesFemaleNeurology (clinical)Cardiology and Cardiovascular MedicinebusinessStroke
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Hemispheric cerebellar rTMS to treat drug-resistant epilepsy: case reports.

2005

Electrical stimulation of the cerebellar cortex by implanted electrodes has been shown to ameliorate refractory epilepsy. We investigated the potential therapeutic role of high-frequency cerebellar rTMS in patients affected by refractory epilepsy due to single or multiple foci. Six patients, three with single and three with multiple epileptic foci, underwent 20 rTMS sessions. Each session was given daily, excluding weekends, and consisted of two trains of 50 stimuli (5 Hz frequency and 90% motor threshold intensity), separated by 50s interval. rTMS was delivered through a focal coil (2 cm below and lateral to the inion) bilaterally in patients with multiple foci (two trains for hemisphere: …

AdultMaleCerebellumFocus (geometry)cerebellummedicine.medical_treatmentDrug Resistancebehavioral disciplines and activitiesCentral nervous system diseaseEpilepsyCerebellar Cortexdrug-resistant epilepsymental disordersrTMSmedicineHumansEpilepsymusculoskeletal neural and ocular physiologyGeneral NeuroscienceDRECortical dysplasiamedicine.diseaseDrug Resistant EpilepsyTranscranial Magnetic StimulationTranscranial magnetic stimulationmedicine.anatomical_structurenervous systemAnesthesiaCerebellar cortexSettore MED/26 - NeurologiaFemalePsychologypsychological phenomena and processesNeuroscience letters
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