Search results for " Ni"
showing 10 items of 3074 documents
Activation of mGlu3 Receptors Stimulates the Production of GDNF in Striatal Neurons
2009
Metabotropic glutamate (mGlu) receptors have been considered potential targets for the therapy of experimental parkinsonism. One hypothetical advantage associated with the use of mGlu receptor ligands is the lack of the adverse effects typically induced by ionotropic glutamate receptor antagonists, such as sedation, ataxia, and severe learning impairment. Low doses of the mGlu2/3 metabotropic glutamate receptor agonist, LY379268 (0.25-3 mg/kg, i.p.) increased glial cell line-derived neurotrophic factor (GDNF) mRNA and protein levels in the mouse brain, as assessed by in situ hybridization, real-time PCR, immunoblotting, and immunohistochemistry. This increase was prominent in the striatum, …
Official Statement of the Spanish Society of Pulmonology and Thoracic Surgery (SEPAR) on Electronic Cigarettes and IQOS®.
2019
The use of novel tobacco products, particularly the electronic cigarette (EC) and partial tobacco combustion devices (HnB systems: Heat not Burn), has increased exponentially, particularly among adolescents and young people. The health authorities and scientific societies have shown concern about issues surrounding safety and effectiveness (as a method of smoking cessation). A study of the available scientific evidence has concluded that the safety of the vapor or fumes inhaled by the users of these devices cannot be guaranteed. Contradictory results from various clinical trials and meta-analyses also mean that these devices cannot be recommended for their effectiveness in cessation, especi…
Novel Combination of Sorafenib and Celecoxib Provides Synergistic Anti-Proliferative and Pro-Apoptotic Effects in Human Liver Cancer Cells
2013
Molecular targeted therapy has shown promise as a treatment for advanced hepatocellular carcinoma (HCC). Sorafenib, a multikinase inhibitor, recently received FDA approval for the treatment of advanced HCC. However, although sorafenib is well tolerated, concern for its safety has been expressed. Celecoxib (Celebrex®) is a selective cyclooxygenase-2 (COX-2) inhibitor which exhibits antitumor effects in human HCC cells. The present study examined the interaction between celecoxib and sorafenib in two human liver tumor cell lines HepG2 and Huh7. Our data showed that each inhibitor alone reduced cell growth and the combination of celecoxib with sorafenib synergistically inhibited cell growth an…
Puhdistumisen ja valaistumisen ideat : taiteilija Ninni Heldtin Kylpijät-kuvasarjan kuvallinen ja filosofinen tulkinta
2014
Tiivistelmä – Abstract Tutkielmassani tarkistan helsinkiläisen taiteilijan Ninni Heldtin Kylpijät kuvasarja. Kuvasarja edustaa Ninni Heldtin eräänlaista ihmistä, naiseksi ja taiteilijaksi kasvun prosessia, joka taiteilija on kokenut itämaisen sahaja joogan ja filosofian harrastuksien kautta ja jotka hän on tuonut näkyviin Kylpijät-nimisessä kuvasarjassa henkisen puhdistumisen ja valaistumisen ideoiden kautta. Ideaa henkisestä puhdistumisesta ja kylpemisestä taiteilija alkoi työstää vuodesta 2010 lähtien. Tällä hetkellä Kylpijä-nimistä teosta on 15 kappaletta. Mahdollisesti taiteilija jatkaa työstää ajatusta lähivuosina. Kylpijät esittävät nimettömiä, puoleksi alastomia, puoleksi pyyheliina-…
Ficciones sobre la expropiación de menores en el régimen franquista y la apropiación de menores en la dictadura argentina: el exterminio ideológico y…
2015
A principios de 2002 se emitió el documental Els nens perduts del franquisme, basado en las investigaciones del historiador Ricard Vinyes sobre las presas políticas y sus hijos en las cárceles franquistas. Hasta ese día las pocas noticias que se tenían de las apropiaciones, venían del otro lado del Atlántico. Las dictaduras latinoamericanas de los años 70 habían marcado el mundo occidental con el fantasma de los desaparecidos y con el robo de sus hijos para “salvarlos” y reeducarlos. Este acto de memoria pública en un medio de comunicación inauguró un nuevo campo de investigación y producción cultural, ya que a partir de ese momento surgieron obras de teatro, novelas, películas y series tel…
Ments alterades en el segle XIX: Els relats d'Edgar Allan Poe i Guy de Moupassant
2014
En el present article s’aborda la confl uencia entre l’autor nord-america Edgar Allan Poe (1809-1849) i l’autor frances Guy de Maupassant (1850-1893), que, a pesar d’estar adscrits a tendencies literaries divergents (romanticisme enfront de realisme/naturalisme), van compartir interessos tematics i formals inequivocs en l’ambit del relat. Partint de les primerenques infl uencies de la contistica de Poe sobre l’escriptura de Maupassant, aquest treball se centra en una seleccio dels relats de l’autor frances que el vinculen literariament a Poe (tant en el terreny tematic com en el narratologic), relacionats amb la fascinacio d’ambdos autors per estats mentals atipics i narradors alterats o «a…
Scanning Tunneling Spectroscope Use in Electrocatalysis Testing
2010
Published version of an article from the journal: Materials (1996-1944). Also available from publisher: http://dx.doi.org/10.3390/ma3063675 The relationship between the electrocatalytic properties of an electrode and its ability to transfer electrons between the electrode and a metallic tip in a scanning tunneling microscope (STM) is investigated. The alkaline oxygen evolution reaction (OER) was used as a test reaction with four different metallic glasses, Ni78Si8B14, Ni70Mo20Si5B5, Ni58Co20Si10B12, and Ni25Co50Si15B10, as electrodes. The electrocatalytic properties of the electrodes were determined. The electrode surfaces were then investigated with an STM. A clear relationship between the…
Bidentate [N, N] nickel complexes with salen type ligands for polymerization of methyl methacrylate
2008
Otrzymano kompleksy niklu [N,N]NiBr2, które po aktywacji związkiem glinoorganicznym zastosowano w polimeryzacji metakrylanu metylu (MMA). Dwukleszczowe ligandy [N,N] uzyskano zastępując w ligandach salenowych grupy hydroksylowe podstawione do pierścieni fenylowych różnymi grupami alkoksylowymi (OMe lub OCH2C6H5). Metyloalumoksan (MAO) okazał się skutecznym aktywatorem kompleksów niklu w polimeryzacji MMA. Same kompleksy bez aktywatora nie wykazywały żadnej aktywności. Stwierdzono, że aktywność badanych układów katalitycznych rośnie ze wzrostem stosunku molowego Al/Ni. W wyniku polimeryzacji w stosowanych warunkach otrzymano poli(metakrylan metylu) (PMMA) z przewagą triad syndiotaktycznych c…
Trophic niche features influence microplastic ingestion in Mediterranean fish species
2022
Widespread microplastic (MP) contamination in the marine environment has raised global concern in the last decade. Scientific evidence of the adverse effects of MP on organisms is growing fast and there is urgent need to fulfil the knowledge gaps about the trophic drivers that lead to such contamination processes and resulting impacts. Fish are considered good bioindicators of MP contamination due to their easy availability, high ecological and commercial value, however our understanding of how trophic niche influences MP ingestion is limited. Here, we investigated the occurrence and abundance of MP in the gastrointestinal tract of 8 commercial fish species (Boops boops, Engraulis encrasico…
Microsatellite analysis of the population structure in Phytophthora nicotianae
2014
Nine validated SSRs were designed and used to characterize 268 isolates from a broad range of hosts and geographic localities. A total of 129 multilocus genotypes (MLG) were identified with markers showing polymorphisms ranging from 4 (locus P2039) to 24 alleles (locus 1509). Analyses revealed a preferential clonal reproduction in field orchards while sexual reproduction seemed to be more diffused in nurseries. A strong association between genetic groups and host of recovery was revealed for most isolates although this association was less evident for isolates from nurseries. In contrast, a significant geographical structuring was recovered only for isolates from tobacco (sourced in Austral…