Search results for " Operative"

showing 10 items of 497 documents

Antilymphocyte Globulin for Prevention of Chronic Graft-versus-Host Disease.

2016

Clinical Trial, Phase III; Journal Article; Multicenter Study; Randomized Controlled Trial; Research Support, Non-U.S. Gov't; BACKGROUND Chronic graft-versus-host disease (GVHD) is the leading cause of later illness and death after allogeneic hematopoietic stem-cell transplantation. We hypothesized that the inclusion of antihuman T-lymphocyte immune globulin (ATG) in a myeloablative conditioning regimen for patients with acute leukemia would result in a significant reduction in chronic GVHD 2 years after allogeneic peripheral-blood stem-cell transplantation from an HLA-identical sibling. METHODS We conducted a prospective, multicenter, open-label, randomized phase 3 study of ATG as part of …

Male:Analytical Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Epidemiologic Methods::Statistics as Topic::Models Statistical::Proportional Hazards Models [Medical Subject Headings]T-LymphocytesPhases of clinical researchGraft vs Host Disease:Named Groups::Persons::Age Groups::Adult::Middle Aged [Medical Subject Headings]Linfocitos t:Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Primates::Haplorhini::Catarrhini::Hominidae::Humans [Medical Subject Headings]Immunosuppressive Agent0302 clinical medicineTrasplante homólogoEstudios prospectivosMedicineCumulative incidenceProspective StudiesProspective cohort studyChildTransplantation Homologou:Chemicals and Drugs::Amino Acids Peptides and Proteins::Proteins::Blood Proteins::Immunoproteins::Immunoglobulins::Antibodies::Immune Sera::Antilymphocyte Serum [Medical Subject Headings]Acute leukemia:Anatomy::Cells::Blood Cells::Leukocytes::Leukocytes Mononuclear::Lymphocytes::T-Lymphocytes [Medical Subject Headings]:Diseases::Pathological Conditions Signs and Symptoms::Pathologic Processes::Disease Attributes::Chronic Disease [Medical Subject Headings]:Named Groups::Persons::Age Groups::Child::Child Preschool [Medical Subject Headings]Medicine (all)IncidenceSuero antilinfocíticoGeneral MedicineMiddle AgedModelos de riesgos proporcionales3. Good healthHumanosSurvival Rate030220 oncology & carcinogenesis:Named Groups::Persons::Age Groups::Adolescent [Medical Subject Headings]Child PreschoolFemale:Chemicals and Drugs::Chemical Actions and Uses::Pharmacologic Actions::Physiological Effects of Drugs::Immunologic Factors::Immunosuppressive Agents [Medical Subject Headings]Immunosuppressive AgentsHumanHomologousAdultmedicine.medical_specialty:Analytical Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Epidemiologic Methods::Epidemiologic Study Characteristics as Topic::Epidemiologic Studies::Cohort Studies::Longitudinal Studies::Prospective Studies [Medical Subject Headings]:Named Groups::Persons::Age Groups::Adult::Young Adult [Medical Subject Headings]AdolescentEnfermedad injerto contra huéspedDisease-Free Survival03 medical and health sciencesYoung AdultInternal medicine:Named Groups::Persons::Age Groups::Adult [Medical Subject Headings]HumansTransplantation HomologousSupervivencia sin enfermedadPreschoolSurvival rate:Analytical Diagnostic and Therapeutic Techniques and Equipment::Diagnosis::Prognosis::Disease-Free Survival [Medical Subject Headings]:Named Groups::Persons::Age Groups::Child [Medical Subject Headings]Antilymphocyte SerumProportional Hazards ModelsTransplantationbusiness.industryEnfermedad crónicamedicine.diseaseInmunosupresoresAnti-thymocyte globulinSurgeryTransplantation:Diseases::Immune System Diseases::Graft vs Host Disease [Medical Subject Headings]Prospective Studie:Analytical Diagnostic and Therapeutic Techniques and Equipment::Surgical Procedures Operative::Transplantation::Transplantation Homologous [Medical Subject Headings]Graft-versus-host diseaseT-Lymphocyte:Check Tags::Female [Medical Subject Headings]Chronic DiseaseProportional Hazards ModelAdolescent; Adult; Antilymphocyte Serum; Child; Child Preschool; Chronic Disease; Disease-Free Survival; Female; Graft vs Host Disease; Humans; Immunosuppressive Agents; Incidence; Male; Middle Aged; Proportional Hazards Models; Prospective Studies; Survival Rate; T-Lymphocytes; Transplantation Homologous; Young Adult; Medicine (all)business030215 immunology
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Fixation-free incisional hernia repair in the elderly: our experience with a tentacle-shaped implant.

2016

Background: Incisional hernia in aged patients represents a challenge even for experienced surgeons. Besides increased risk of complications due to comorbidities, mesh fixation and assuring a sufficient mesh overlap of the defect are the main issues in carrying out the repair. Aims: In order to assure broader coverage of the abdominal wall and a tension- and fixation-free repair, a specifically designed prosthesis was developed for the surgical treatment of incisional hernias. The results of a fixation-free incisional hernia repair carried out in elderly patients using a tentacle-shaped implant are reported herewith. Methods: A tentacle-shaped flat mesh with a large central body and integra…

MaleAgingmedicine.medical_specialtyAbdominal Wound Closure TechniquesFrictionIncisional herniamedicine.medical_treatment030230 surgeryProsthesisAbdominal wall03 medical and health sciences0302 clinical medicineHematomaPostoperative ComplicationsRecurrenceSublaymedicineHumansIncisional HerniaAgedAged 80 and overSurgical fixation deviceTentacle meshbusiness.industryAbdominal Wound Closure TechniquesProstheses and ImplantsSurgical Meshmedicine.diseaseHernia VentralSurgerysurgical procedures operativemedicine.anatomical_structureSurgical meshVentral herniaOutcome and Process Assessment Health Care030220 oncology & carcinogenesisTechniqueFemaleImplantGeriatrics and GerontologyFast trackbusinessAging clinical and experimental research
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The Genotype of the Donor for the (GT)n Polymorphism in the Promoter/Enhancer of FOXP3 Is Associated with the Development of Severe Acute GVHD but Do…

2015

The FOXP3 gene encodes for a protein (Foxp3) involved in the development and functional activity of regulatory T cells (CD4+/CD25+/Foxp3+), which exert regulatory and suppressive roles over the immune system. After allogeneic stem cell transplantation, regulatory T cells are known to mitigate graft versus host disease while probably maintaining a graft versus leukemia effect. Short alleles (<=(GT)(15)) for the (GT)(n) polymorphism in the promoter/enhancer of FOXP3 are associated with a higher expression of FOXP3, and hypothetically with an increase of regulatory T cell activity. This polymorphism has been related to the development of auto-or alloimmune conditions including type 1 diabetes …

MaleAnálisis de supervivenciatrasplante de células madre hematopoyéticasmedicine.medical_treatmenthumanos:Analytical Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Epidemiologic Methods::Statistics as Topic::Survival Analysis [Medical Subject Headings]Graft vs Host Diseaselcsh:MedicinePolimorfismo genético:Named Groups::Persons::Age Groups::Adult::Middle Aged [Medical Subject Headings]Hematopoietic stem cell transplantationStem cellsRegiones promotoras genéticas:Analytical Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Genetic Techniques::Genetic Association Studies [Medical Subject Headings]:Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Primates::Haplorhini::Catarrhini::Hominidae::Humans [Medical Subject Headings]Trasplante homólogoIL-2 receptorLymphocytesMasculinoPromoter Regions Geneticlcsh:Sciencemediana edadancianoMultidisciplinaryAdultoFemenino:Analytical Diagnostic and Therapeutic Techniques and Equipment::Surgical Procedures Operative::Transplantation::Cell Transplantation::Stem Cell Transplantation::Hematopoietic Stem Cell Transplantation [Medical Subject Headings]Hematopoietic Stem Cell TransplantationFOXP3Forkhead Transcription Factorsadultoanálisis de supervivenciaMiddle AgedTissue DonorsHumanosestudios de asociación genéticaadulto jovenmedicine.anatomical_structuresurgical procedures operativeCèl·lules T:Chemicals and Drugs::Amino Acids Peptides and Proteins::Proteins::Transcription Factors::Winged-Helix Transcription Factors::Forkhead Transcription Factors [Medical Subject Headings]Female:Phenomena and Processes::Genetic Phenomena::Genotype [Medical Subject Headings]Factores de transcripción en cabeza de tenedorCèl·lules mareTrasplante de células madre hematopoyéticasResearch ArticleAdult:Named Groups::Persons::Age Groups::Adult::Young Adult [Medical Subject Headings]GenotypeGraft-vs-Leukemia EffectRegulatory T cellAncianoT cells:Check Tags::Male [Medical Subject Headings]Graft vs Leukemia Effectfactores de transcripción en cabeza de tenedorHuman leukocyte antigenBiologyEnfermedad injerto contra huéspedLimfòcitsYoung AdultDonantes de tejidos:Named Groups::Persons::Tissue Donors [Medical Subject Headings]:Named Groups::Persons::Age Groups::Adult [Medical Subject Headings]medicineHumansTransplantation Homologous:Named Groups::Persons::Age Groups::Adult::Aged [Medical Subject Headings]Genetic Association StudiesAgedMediana edadTransplantationPolymorphism GeneticEstudios de asociación genéticaEfecto injerto contra leucemialcsh:Rdonantes de tejidostrasplante:Phenomena and Processes::Genetic Phenomena::Genetic Variation::Polymorphism Genetic [Medical Subject Headings]medicine.diseaseSurvival Analysis:Diseases::Immune System Diseases::Graft vs Host Disease [Medical Subject Headings]Transplantation:Analytical Diagnostic and Therapeutic Techniques and Equipment::Surgical Procedures Operative::Transplantation::Transplantation Homologous [Medical Subject Headings]efecto injerto contra leucemiaGraft-versus-host disease:Check Tags::Female [Medical Subject Headings]Immunology:Phenomena and Processes::Immune System Phenomena::Immune System Processes::Transplantation Immunology::Graft vs Host Reaction::Graft vs Tumor Effect::Graft vs Leukemia Effect [Medical Subject Headings]enfermedad injerto contra huésped:Phenomena and Processes::Genetic Phenomena::Genetic Structures::Genome::Genome Components::Genes::Gene Components::Regulatory Elements Transcriptional::Promoter Regions Genetic [Medical Subject Headings]lcsh:QgenotipoGenotipoPLoS ONE
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A New Off-Pump Hybrid Open and Endovascular Repair to Treat Ductus Botalli and Ascendens Aneurysms

2012

To report a combined ascending aorta and aortic arch hybrid repair, we performed off-pump with no aortic graft replacement. A 65-year-old man, developing progressive recurrent laryngeal nerve paralysis, underwent a computed tomography (CT) angiography detecting nonpatent residual ductus Botalli aneurysm and ascending aorta aneurysm. Due to severe multimorbidities, a less-invasive alternative was elaborated. In a first step, appropriate proximal landing zone for aortic stent grafting was achieved by ascending aorta diameter reduction, with epiaortic wrapping, and debranching the supra-aortic trunks. In the second step, endovascular stent grafts were deployed from proximal ascending aorta to…

MaleAortic archmedicine.medical_specialtyAortographymedicine.medical_treatment610 Medicine & healthAorta ThoracicAortographySettore MED/22 - Chirurgia Vascolare2705 Cardiology and Cardiovascular MedicineBlood Vessel Prosthesis ImplantationAortic aneurysmAneurysmmedicine.arteryAscending aortamedicineHumansThoracic aortacardiovascular diseasesDuctus Arteriosus PatentAgedCardiopulmonary Bypassmedicine.diagnostic_test10042 Clinic for Diagnostic and Interventional Radiologybusiness.industryEndovascular Proceduresaortic arch aortic operation carotid afteries endovascular procedures vascular diseaseStentGeneral Medicinemedicine.disease10020 Clinic for Cardiac Surgery2746 SurgeryAortic AneurysmSurgeryTreatment Outcomesurgical procedures operativeDescending aortacardiovascular systemSurgeryRadiologyTomography X-Ray ComputedCardiology and Cardiovascular MedicinebusinessVascular and Endovascular Surgery
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Choice of CTO scores to predict procedural success in clinical practice. A comparison of 4 different CTO PCI scores in a comprehensive national regis…

2021

Background We aimed to compare the performance of the recent CASTLE score to J-CTO, CL and PROGRESS CTO scores in a comprehensive database of percutaneous coronary intervention of chronic total occlusion procedures. Methods Scores were calculated using raw data from 1,342 chronic total occlusion procedures included in REBECO Registry that includes learning and expert operators. Calibration, discrimination and reclassification were evaluated and compared. Results Mean score values were: CASTLE 1.60±1.10, J-CTO 2.15±1.24, PROGRESS 1.68±0.94 and CL 2.52±1.52 points. The overall percutaneous coronary intervention success rate was 77.8%. Calibration was good for CASTLE and CL, but not for J-CTO…

MaleCalibraciónCardiovascular ProceduresPhysiologymedicine.medical_treatmentMyocardial InfarctionSocial SciencesVasos coronariosCardiovascular MedicineSeverity of Illness IndexPercutaneous coronary intervention:Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Primates::Haplorhini::Catarrhini::Hominidae::Humans [Medical Subject Headings]:Analytical Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Calibration [Medical Subject Headings]Learning and MemoryMedical ConditionsMedicine and Health SciencesPsychologyRegistries:Persons::Persons::Age Groups::Adult::Aged [Medical Subject Headings]Coronary Artery Bypass GraftingMultidisciplinaryQ:Analytical Diagnostic and Therapeutic Techniques and Equipment::Surgical Procedures Operative::Cardiovascular Surgical Procedures::Vascular Surgical Procedures::Endovascular Procedures::Percutaneous Coronary Intervention [Medical Subject Headings]RIntervención coronaria percutáneaMiddle AgedPrognosisInterventional CardiologyClinical PracticeTreatment Outcome:Analytical Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Epidemiologic Methods::Data Collection::Health Surveys::Health Status Indicators::Patient Acuity::Severity of Illness Index [Medical Subject Headings]Cardiovascular DiseasesIntegrated discrimination improvementArea Under CurveCohortCalibrationMedicineFemaleResearch ArticleLearning Curvesmedicine.medical_specialtyCoronary StentingScienceCardiologyMEDLINE:Check Tags::Male [Medical Subject Headings]Surgical and Invasive Medical ProceduresCoronary arteryRisk AssessmentTotal occlusionCalcificationPercutaneous Coronary InterventionmedicineHumansLearningRegistrosAged:Analytical Diagnostic and Therapeutic Techniques and Equipment::Diagnosis::Prognosis::Treatment Outcome [Medical Subject Headings]business.industryAngioplasty:Analytical Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Epidemiologic Methods::Statistics as Topic::Probability::Risk::Risk Assessment [Medical Subject Headings]Cognitive Psychology:Analytical Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Epidemiologic Methods::Statistics as Topic::Area Under Curve [Medical Subject Headings]Biology and Life SciencesPercutaneous coronary intervention:Persons::Persons::Age Groups::Adult::Middle Aged [Medical Subject Headings]Cardiovascular Disease Risk:Diseases::Cardiovascular Diseases::Heart Diseases::Myocardial Ischemia::Coronary Disease::Coronary Occlusion [Medical Subject Headings]Coronary Occlusion:Check Tags::Female [Medical Subject Headings]Stent ImplantationConventional PCIPhysical therapyCognitive Science:Analytical Diagnostic and Therapeutic Techniques and Equipment::Diagnosis::Prognosis [Medical Subject Headings]National registry:Analytical Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Epidemiologic Methods::Data Collection::Registries [Medical Subject Headings]Physiological ProcessesbusinessCoronary AngioplastyNeuroscience
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Cardiac risk stratification in elective non-cardiac surgery: Role of NT-proBNP

2011

AIM: The aim of the study was to investigate the utility of NT-proBNP measurement for the stratification of presurgical cardiac risk. METHODS: Cardiac risk before elective non-cardiac surgery was evaluated in 82 consecutive patients. From each patient a venous blood sample was drawn to determinate NT-proBNP levels. Patients were followed up over three months in order to detect the occurrence of cardiac adverse events. RESULTS: NT-proBNP was positively correlated (P<0.0001) with age, days of hospitalization (P=0.001) and ASA class (P=0.001). High surgical risk (P<0.0001), diabetes (P=0.004), dyslipidemia (P=0.006) and elevated levels of NT-proBNP (P<0.0001) were significantly correlated with…

MaleChi-Square DistributionTime FactorsMiddle AgedRisk AssessmentPeptide FragmentsUp-RegulationLogistic ModelsTreatment OutcomeItalyNT-proBNPCardiovascular DiseasesElective Surgical ProceduresPredictive Value of TestsRisk FactorsSurgical Procedures OperativeNatriuretic Peptide BrainPreoperative PeriodOdds RatioHumansFemaleBiomarkersAged
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Impact of conversion from laparoscopy to open surgery in patients with right colon cancer

2019

Conversion to open surgery is reported in up to 20 per cent of laparoscopic colectomies for cancer. This study aims to compare postoperative outcomes and survival between converted and successful laparoscopic right colectomy for cancer. Records of patients who underwent laparoscopic right colectomy for cancer between 2005 and 2015 were retrieved from the CLermontFerrand Ircad Mondor Hopital European Tours (CLIMHET) database. Perioperative, postoperative, and survival outcomes were evaluated. Multivariate analysis was performed to identify predictive factors for conversion. Overall, 445 patients underwent a successfully completed laparoscopic right colectomy and 28 (5.9%) were converted to …

MaleColectomiesmedicine.medical_specialtyColorectal cancermedicine.medical_treatmentOperative TimeDisease-Free SurvivalmedicineHumansLaparoscopySurvival rateColectomyColectomyconversion laparoscopy colon cancermedicine.diagnostic_testbusiness.industryCancerGeneral MedicinePerioperativemedicine.diseaseConversion to Open SurgerySurgerySurvival RateSettore MED/18 - Chirurgia GeneraleTreatment Outcomecolonic neoplasms; disease-free survival; female; humans; male; operative time; survival rate; treatment outcome; colectomy; conversion to open surgery;laparoscopyColonic NeoplasmsRight ColectomyFemaleLaparoscopybusiness
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Absolok® versus Hem-o-Lok® clips for renorrhaphy during partial nephrectomy for parenchymal renal tumors

2020

Background To compare perioperative and functional outcomes associated with renorrhaphy performed with two different types of clips (Absolok® vs. Hem-o-Lok®) in a contemporary series of patients who underwent partial nephrectomy. Methods Patients in whom Absolok® clips were used to perform haemostasis at the level of tumor bed or to block the running sutures during sliding-clip renorrhaphy (study group) were compared with a contemporary control group of patients in whom renorrhaphy was performed with Hem-o-Lok® clips. Both groups received the same surgical technique via an open or robot-assisted approach. Inner renorrhaphy was performed with one or more 3-0 (26 mm needle) monofilament runni…

MaleComplicationsmedicine.medical_treatment030232 urology & nephrologyKidneyNephrectomyPolydioxanonechemistry.chemical_compoundPostoperative Complications0302 clinical medicinePerioperative outcomesRobotic Surgical ProceduresSuture (anatomy)bsolok® clipPartial nephrectomyMedicineProspective StudiesCLIPSIntraoperative ComplicationsProspective cohort studycomputer.programming_languageMiddle AgedSurgical InstrumentsMagnetic Resonance ImagingRenal cell carcinomaKidney NeoplasmsNephrectomyTreatment Outcomesurgical procedures operativeNephrologyPolydioxanone030220 oncology & carcinogenesiscardiovascular systemFemalePositive Surgical MarginAbsolok (R) clips Hem-o-lok (R) clips Renorrhaphy Sliding clip technique Partial nephrectomy Perioperative outcomes Complications Renal cell carcinomaPerioperative outcomeHem-o-Lok® clipmedicine.medical_specialtyKidney CortexUrologyeducationSliding clip technique03 medical and health sciencesHumansRenorrhaphycardiovascular diseasesAgedHemostasisAbsolok (R) clipsSuturesbusiness.industryPerioperativeSurgeryHem-o-lok (R) clipschemistryHemostasisTomography X-Ray ComputedbusinessComplicationcomputerMinerva Urologica e Nefrologica
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The Impact of Endoscopic Ultrasound and Computed Tomography on the TNM Staging of Early Cancer in Barrett's Esophagus

2006

Computed tomography (CT) and endoscopic ultrasound (EUS) are part of the regular staging protocol in esophageal cancer. The value of the two methods was assessed in patients with early cancer in Barrett's esophagus.One hundred consecutive patients (median age 64 yr, interquartile range [IQR] 58-72) with suspected early cancer in Barrett's esophagus who were referred to our hospital for endoscopic therapy were prospectively included in a standardized staging program with upper gastrointestinal endoscopy, EUS (7.5 MHz in all cases plus 12.5 or 20 MHz for elevated and/or depressed lesions), CT of the chest and upper abdomen, and abdominal ultrasonography. The results were summarized in accorda…

MaleEndoscopic ultrasoundmedicine.medical_specialtyEarly cancerEsophageal NeoplasmsAdenocarcinomadigestive systemEndosonographyBarrett EsophagusPredictive Value of TestsmedicineHumansProspective StudiesEsophagusneoplasmsAgedNeoplasm StagingHepatologymedicine.diagnostic_testbusiness.industryEsophageal diseaseUltrasoundGastroenterologyReproducibility of ResultsMiddle Agedmedicine.diseasedigestive system diseasesEndoscopystomatognathic diseasessurgical procedures operativemedicine.anatomical_structureBarrett's esophagusFemaleRadiologyTomographyTomography X-Ray ComputedbusinessThe American Journal of Gastroenterology
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Frailty syndrome and pre-operative risk evaluation: A systematic review

2015

Abstract Background Frailty is a geriatric syndrome characterized by the clinical presentation of identifiable physical alterations and decreased physiological reserve. The assessment of frailty syndrome has been recently related with post-surgical outcomes and overall mortality in older individuals. Design and data sources We performed searches in Pubmed, Embase, Scopus, SCIELO and IME (Spanish medical index) databases from their start dates to February 2014 for original papers about the identification of the relationship between frailty and pre-operative risk evaluation in people aged 65 and over. Review methods We followed criteria of systematic PRISMA guidelines. Two independent reviewe…

MaleGerontologyAgingmedicine.medical_specialtyHealth (social science)Frail ElderlyFrailty syndromeScopusPhysical examinationDiagnostic toolsRisk AssessmentmedicineHumansPhysical ExaminationAgedAged 80 and overmedicine.diagnostic_testbusiness.industryMortality ratemedicine.diseasePre operativeRisk evaluationPreoperative PeriodPhysical therapyFemaleGeriatrics and GerontologyRisk assessmentbusinessGerontologyArchives of Gerontology and Geriatrics
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