Search results for " Optical Coherence"

showing 10 items of 140 documents

Intravitreal therapies for non-neovascular age-related macular degeneration with intraretinal or subretinal fluid

2017

OBJECTIVE: To evaluate the efficacy of intravitreal therapies in cases of atrophic age-related macular degeneration (AMD) with subretinal or intraretinal fluid. METHODS: A retrospective review was made of the clinical charts of patients diagnosed with atrophic AMD with subretinal or intraretinal fluid. Fundus photographs and spectral-domain optical coherence tomography images were examined, and an analysis was made on the presence of fluid and its density. Neovascularisation was ruled out by fluorescein and/or indocyanine green angiography. RESULTS: The study included 14 eyes from 13 patients with a mean age of 72.64 years and a mean follow-up of 80.5 weeks. Intraretinal fluid was observed …

MaleDegeneracion macular asociada a la edad no neovascularVisual acuityTriamcinolone acetonidegenetic structuresFluido subretinianoAngiogenesis InhibitorsFundus (eye)Triamcinolone0302 clinical medicineDegeneración macular asociada a la edad no neovascular Fluido intrarretiniano Fluido subretiniano Intraretinal fluid Intravitreal therapies Non-neovascular age related macular degeneration Spectral domain optical coherence tomography Subretinal fluid Terapias intravítreas Tomografía de coherencia óptica de dominio espectralFluorescein AngiographyTomografia de coherencia optica de dominio espectralAged 80 and overmedicine.diagnostic_testSubretinal FluidExudates and TransudatesGeneral MedicineFluorescein angiographyFluido intrarretinianoBevacizumabTreatment Outcomemedicine.anatomical_structureIntravitreal InjectionsFemalemedicine.symptomIntravitreal therapiesTomography Optical Coherencemedicine.drugSubretinal fluidmedicine.medical_specialtyBevacizumabRetinal DrusenRetinaSpectral domain optical coherence tomography03 medical and health sciencesNon-neovascular age related macular degenerationRanibizumabOphthalmologymedicineHumansAgedRetinabusiness.industryMacular degenerationmedicine.diseaseTerapias intravitreaseye diseasesSurgeryWet Macular Degeneration030221 ophthalmology & optometryIntraretinal fluidsense organsRanibizumabbusiness030217 neurology & neurosurgeryArchivos de la Sociedad Española de Oftalmología (English Edition)
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Deep Learning Estimation of 10-2 and 24-2 Visual Field Metrics Based on Thickness Maps from Macula OCT.

2021

Purpose To develop deep learning (DL) systems estimating visual function from macula-centered spectral-domain (SD) OCT images. Design Evaluation of a diagnostic technology. Participants A total of 2408 10-2 visual field (VF) SD OCT pairs and 2999 24-2 VF SD OCT pairs collected from 645 healthy and glaucoma subjects (1222 eyes). Methods Deep learning models were trained on thickness maps from Spectralis macula SD OCT to estimate 10-2 and 24-2 VF mean deviation (MD) and pattern standard deviation (PSD). Individual and combined DL models were trained using thickness data from 6 layers (retinal nerve fiber layer [RNFL], ganglion cell layer [GCL], inner plexiform layer [IPL], ganglion cell-IPL […

MaleDesign evaluationGlaucoma03 medical and health sciences0302 clinical medicinePattern standard deviationDeep LearningLinear regressionDiagnostic technologyMedicineHumansMacula LuteaIntraocular Pressure030304 developmental biologyAged0303 health sciencesbusiness.industryOutcome measuresGlaucomaMiddle Agedmedicine.diseaseConfidence intervalVisual fieldOphthalmologyBenchmarkingCross-Sectional Studies030221 ophthalmology & optometryFemaleVisual FieldsbusinessNuclear medicineTomography Optical CoherenceFollow-Up StudiesOphthalmology
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Association of ocular, cardiovascular, morphometric and lifestyle parameters with retinal nerve fibre layer thickness.

2017

BACKGROUND Glaucoma is a neurodegenerative disease, leading to thinning of the retinal nerve fibre layer (RNFL). The exact influence of ocular, cardiovascular, morphometric, lifestyle and cognitive factors on RNFL thickness (RNFLT) is unknown and was analysed in a subgroup of the Gutenberg Health Study (GHS). METHODS Global peripapillary RNFLT was measured in 3224 eyes of 1973 subjects (49% female) using spectral-domain optical coherence tomography (SD-OCT). The association of age, sex, ocular, cardiovascular, morphometric, lifestyle and cognitive factors on RNFLT was analysed using Pearson correlation coefficient and fitting a linear mixed model. RESULTS In the univariable analysis highest…

MaleHomocysteineEye Diseasesgenetic structuresGlaucomalcsh:MedicineBlood PressureOtologyVascular MedicineDiagnostic Radiologychemistry.chemical_compoundTinnitus0302 clinical medicineNerve FibersAnimal CellsMedicine and Health SciencesProspective StudiesProspective cohort studylcsh:Science610 Medicine & healthTomographyHearing DisordersAged 80 and overNeuronsMultidisciplinaryAlcohol ConsumptionRadiology and ImagingAxial lengthMiddle AgedAxial Length EyeLifestyle factorsNeurologyRegression AnalysisFemaleCellular TypesAnatomyTomography Optical CoherenceResearch ArticleAdultmedicine.medical_specialtyImaging TechniquesNerve fibre layer610 Medicine & healthHomocysteine levelsResearch and Analysis MethodsRetina03 medical and health sciencesSex FactorsOcular SystemDiagnostic MedicineOphthalmologymedicineHumansddc:610Life StyleAgedNutritionbusiness.industryMorphometrylcsh:RBiology and Life SciencesRetinalGlaucomaCell Biologymedicine.diseaseeye diseasesDietOphthalmologychemistryOtorhinolaryngologyCellular Neuroscience030221 ophthalmology & optometryEyeslcsh:Qsense organsbusinessHead030217 neurology & neurosurgeryNeuroscience
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Intravitreal aflibercept for the treatment of radiation-induced macular edema after ruthenium 106 plaque radiotherapy for choroidal melanoma.

2019

Purpose: To assess the efficacy of intravitreal aflibercept in patients suffering from post-radiation macular edema following plaque radiotherapy for choroidal melanoma. Methods: This prospective, interventional case series included patients affected by radiation maculopathy (RM) with macular edema secondary to ruthenium-106 plaque brachytherapy for choroidal melanoma. The effect of intravitreal aflibercept on best-corrected visual acuity (BCVA), central foveal thickness (CFT) detected by spectral domain optical coherence tomography (sd-OCT), and Horgan’s grading scale of RM was evaluated throughout the 24-month follow-up. Intraocular pressure (IOP) and possible complications were also reco…

MaleIntraocular pressureFovea CentralisVisual acuitygenetic structuresmedicine.medical_treatmentBrachytherapyVisual AcuityIntravitreal aflibercept; Plaque brachytherapy; Radiation maculopathy; Aged; Brachytherapy; Choroid Neoplasms; Dose-Response Relationship Drug; Dose-Response Relationship Radiation; Female; Fluorescein Angiography; Follow-Up Studies; Fovea Centralis; Fundus Oculi; Humans; Intravitreal Injections; Macular Edema; Male; Melanoma; Middle Aged; Prospective Studies; Receptors Vascular Endothelial Growth Factor; Recombinant Fusion Proteins; Ruthenium Radioisotopes; Tomography Optical Coherence; Treatment Outcome; Visual Acuity0302 clinical medicineEndophthalmitisReceptorsProspective StudiesFluorescein AngiographyTomographyMelanomaAfliberceptRadiationmedicine.diagnostic_testVascular Endothelial Growth FactorChoroid NeoplasmsMiddle AgedFluorescein angiographySensory SystemsTreatment OutcomeIntravitreal InjectionsFemaleIntravitreal aflibercept; Plaque brachytherapy; Radiation maculopathy; Aged; Brachytherapy; Choroid Neoplasms; Dose-Response Relationship; Drug; Dose-Response Relationship; Radiation; Female; Fluorescein Angiography; Follow-Up Studies; Fovea Centralis; Fundus Oculi; Humans; Intravitreal Injections; Macular Edema; Male; Melanoma; Middle Aged; Prospective Studies; Receptors; Vascular Endothelial Growth Factor; Recombinant Fusion Proteins; Ruthenium Radioisotopes; Tomography; Optical Coherence; Treatment Outcome; Visual Acuitymedicine.symptomIntravitreal afliberceptDrugRuthenium RadioisotopesTomography Optical CoherenceHumanmedicine.drugmedicine.medical_specialtyFundus OculiRecombinant Fusion ProteinsRuthenium RadioisotopeMacular EdemaFollow-Up StudieDose-Response Relationship03 medical and health sciencesCellular and Molecular NeuroscienceRadiation maculopathyOphthalmologymedicineHumansMacular edemaAgedFovea CentraliDose-Response Relationship Drugbusiness.industryPlaque radiotherapyIntravitreal InjectionPlaque brachytherapyDose-Response Relationship Radiationmedicine.diseaseeye diseasesProspective StudieOphthalmologyReceptors Vascular Endothelial Growth FactorOptical Coherence030221 ophthalmology & optometryMaculopathysense organsbusinessChoroid Neoplasm030217 neurology & neurosurgeryRecombinant Fusion ProteinFollow-Up StudiesGraefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie
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Biodegradable collagen matrix implant versus mitomycin-C in trabeculectomy: five-year follow-up.

2015

Background Clinical studies comparing trabeculectomy augmented with Ologen implant (OLO) versus trabeculectomy plus mitomycin-C (MMC) show contradictory results. To obtain long-term data, we report an extended 5-year follow-up trial evaluating the safety and efficacy of OLO as adjuvant compared to low-dosage MMC in trabeculectomy. Methods Forty glaucoma patients (40 eyes) assigned to trabeculectomy with MMC or Ologen. Primary outcome: target IOP at ≤21, ≤17 and ≤15 mmHg; complete and qualified success endpoint rates. Secondary outcomes: visual acuity (VA), mean deviation (MD), bleb evaluation, according to Moorfields Bleb Grading System (MBGS); spectral domain OCT (SD-OCT) bleb examination;…

MaleIntraocular pressureVisual acuitygenetic structuresmedicine.medical_treatmentVisual AcuityGlaucomaExfoliation Syndrome0302 clinical medicineAbsorbable ImplantsTrabeculectomyExtended 5-yrs follow-upExtended 5-yrs follow-up; Mitomycin-C; Ologen; Trabeculectomy;GlycosaminoglycansGeneral MedicineMiddle AgedMitomycin-CFemaleCollagenmedicine.symptomGlaucoma Open-AngleTomography Optical CoherenceHumanResearch ArticleAdultmedicine.medical_specialtyAlkylating AgentsMitomycinTrabeculectomyOlogenFollow-Up Studie03 medical and health sciencesAbsorbable ImplantOphthalmologymedicineHumansIntraocular PressureAgedSettore MED/30 - Malattie Apparato Visivobusiness.industryMitomycin CFive year follow upANTIGLAUCOMA MEDICATIONSAlkylating Agentmedicine.diseaseeye diseasesSurgeryOphthalmologyGlycosaminoglycan030221 ophthalmology & optometryImplantsense organsbusiness030217 neurology & neurosurgeryFollow-Up StudiesBMC ophthalmology
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Biodegradable collagen matrix implant vs mitomycin-C as an adjuvant in trabeculectomy: a 24-month, randomized clinical trial

2011

AIM: To verify the safety and efficacy of Ologen (OLO) implant as adjuvant compared with low-dosage mitomycin-C (MMC) in trabeculectomy. METHODS: This was a prospective randomized clinical trial with a 24-month follow-up. Forty glaucoma patients (40 eyes) were assigned to trabeculectomy with MMC or OLO. Primary outcome includes target IOP at ≤21, ≤17, and ≤15 mm Hg; complete (target IOP without medications), and qualified success (target IOP regardless of medications). Secondary outcomes include bleb evaluation, according to Moorfields Bleb Grading System (MBGS); spectral domain optical coherence tomography (SD-OCT) examination; number of glaucoma medications; and frequency of postoperative…

MaleIntraocular pressuremedicine.medical_specialtymedicine.medical_treatmentMitomycinGlaucomaTrabeculectomyMatrix (biology)law.inventionRandomized controlled triallawAbsorbable ImplantsmedicineTrabeculectomyHumansProspective StudiesIntraocular PressureAgedGlycosaminoglycansIntraoperative CareSettore MED/30 - Malattie Apparato Visivobusiness.industryMitomycin CGlaucomaProstheses and ImplantsMiddle AgedOlogen MMC trabeculectomymedicine.diseaseSurgeryOphthalmologyCross-Linking ReagentsClinical StudyFemaleImplantCollagenbusinessAdjuvantTomography Optical Coherence
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Determination of corneal volume from anterior topography and topographic pachymetry: application to healthy and keratoconic eyes

2009

Purpose: To describe a method to measure corneal volume from topography and pachymetry, and test its clinical use on a sample of healthy human subjects and a case of circumscribed posterior keratoconus. Methods: Corneal curvature (PCT 200® corneal topography system; Optopol Technology SA, Zawiercie, Poland) and ultrasonic topographic pachometry on 25 points (Ophthasonic ® A-Scan/Pachometer III; Teknar Inc., St Louis, MO, USA) were measured on each of 12 young healthy corneas and one cornea suffering from circumscribed posterior keratoconus. Topography and pachymetry data were used to calculate the coordinates for the corresponding points on the posterior surface of the cornea. TableCurve 3D…

MaleKeratoconusmedicine.medical_specialtygenetic structuresEye diseaseKeratoconusSensitivity and SpecificityCorneaYoung Adult03 medical and health sciences0302 clinical medicineCorneaOphthalmologymedicineHumansPosterior keratoconusCorneal pachymetry030304 developmental biology0303 health sciencesmedicine.diagnostic_testbusiness.industryCorneal TopographyCorneal topographymedicine.diseaseeye diseasesSensory SystemsOphthalmologymedicine.anatomical_structure030221 ophthalmology & optometryFemalesense organsTomographybusinessTomography Optical CoherenceOptometryVolume (compression)Ophthalmic and Physiological Optics
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Assessment of anterior segment measurements using a high-resolution imaging device

2020

To assess the repeatability of several anterior segment parameters obtained with swept-source optical coherence tomography (SS-OCT).We measured 5-times consequently several parameters in 69 eyes using the ANTERION SS-OCT. White-to-white (WTW), angle-to-angle (ATA), spur-to-spur (STS), and lens vault distances were measured in the horizontal- and vertical-meridian. Anterior-chamber-angle (ACA), scleral-spur-angle (SSA), angle-opening-distance (AOD), and trabecular-iris-space-area (TISA) were measured at 500 and 750 μm for the superior-, nasal-,inferior-, and temporal-quadrants. Intrasubject standard deviation (Sw),coefficient of variation (CoV), coefficient of repeatability (CoR), and intrac…

MaleMaterials sciencegenetic structuresAnterior ChamberBiomedical EngineeringIrismacromolecular substances030204 cardiovascular system & hematology03 medical and health sciences0302 clinical medicineOpticsOptical coherence tomographyLens CrystallinemedicineHumansmedicine.diagnostic_testbusiness.industryResolution (electron density)Reproducibility of ResultsGeneral MedicineRepeatabilityeye diseasesnervous systemFemaleSurgerysense organsbusinessAlgorithmsTomography Optical Coherence030217 neurology & neurosurgeryExpert Review of Medical Devices
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Irregularity of the posterior corneal surface after curved interface femtosecond laser-assisted versus microkeratome-assisted descemet stripping auto…

2013

During donor tissue preparation for Descemet stripping automated endothelial keratoplasty (DSAEK), either microkeratome or femtosecond laser can be used for intrastromal cutting. We compared morphological and functional outcomes after DSAEK using both cutting techniques.In this retrospective study, 22 uneventful DSAEK surgeries were reviewed. Eight donor corneas were prepared for DSAEK using the VisuMax femtosecond laser (Carl Zeiss Meditec AG, Jena, Germany). Fourteen corneas were processed using an Amadeus II microkeratome (Ziemer Ophthalmic Systems AG, Port, Switzerland). The postoperative best spectacle-corrected visual acuity was measured. Furthermore, corneal optical coherence tomogra…

MaleMaterials sciencegenetic structuresDonor tissueVisual AcuityCell Countlaw.inventionOpticsOrgan Culture TechniqueslawMicrokeratomeHumansCorneal surfaceAgedRetrospective StudiesAged 80 and overbusiness.industryEndothelium CornealFuchs' Endothelial DystrophyCorneal TopographyMiddle AgedDescemet stripping automated endothelial keratoplastyLaser assistedLasereye diseasesTissue DonorsOphthalmologyFemtosecondFemalesense organsLaser TherapybusinessDescemet Stripping Endothelial KeratoplastyTomography Optical CoherenceBiomedical engineeringCornea
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Ocular Phenotype of Relaxin Gene Knockout (Rln-/-) Mice

2020

Purpose: To test if relaxin deficiency affects ocular structure and function we investigated expression of relaxin (Rln) and RXFP receptors (Rxfp1, Rxfp2), and compared ocular phenotypes in relaxin gene knockout (Rln-/- ) and wild type (Rln+/+ ) mice. Materials and Methods: Rln, Rxfp1 and Rxfp2 mRNA expression was detected in ocular tissues of Rln+/+ mice using RT-PCR. The eyes of 11 Rln-/- and 5 Rln+/+ male mice were investigated. Corneal and retinal thickness was assessed using optical coherence tomography. Intraocular pressure was measured using a rebound tonometer. Retinal, choroidal and sclera morphology and thickness were evaluated histologically. Eyes were collected and fixed for imm…

MalePathologymedicine.medical_specialtygenetic structuresAquaporinsReal-Time Polymerase Chain ReactionRetinaReceptors G-Protein-CoupledCorneaGene Knockout TechniquesMiceTonometry Ocular03 medical and health sciencesCellular and Molecular Neurosciencechemistry.chemical_compound0302 clinical medicineCorneamedicineAnimalsRNA MessengerIntraocular PressureGene knockoutMice KnockoutRelaxinExtracellular Matrix ProteinsRetinaChoroidChemistryRelaxinRetinalFluid transporteye diseasesSensory SystemsScleraMice Inbred C57BLOphthalmologyPhenotypemedicine.anatomical_structureGene Expression Regulation030221 ophthalmology & optometryImmunohistochemistryFemalesense organsScleraTomography Optical Coherence030217 neurology & neurosurgeryCurrent Eye Research
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