Search results for " PC"
showing 10 items of 434 documents
Stent oversizing or not-oversizing? An unresolved dilemma
2021
Primary PCI plus stent implantation is indicated for treatment of acute coronary syndrome. Technically, due to the difference in lumen diameter between vessel portions and stent size in some coronary arteries, post-expansion of the stent is usually necessary to match proximal reference diameter and optimize stent apposition. Incomplete stent apposition has been associated with increased risk of in stent restenosis (ISR) and stent thrombosis (1) despite new stent technologies have largely reduced this risk (2-3). Although new antiplatelet drugs showed a more rapid onset of action and a stronger effect (4-5), stent apposition remains an important risk factor for stent thrombosis. As stent pos…
Inclisiran: a small interfering RNA strategy targeting PCSK9 to treat hypercholesterolemia
2022
Introduction: Inclisiran is a novel posttranscriptional gene silencing therapy that inhibits proprotein convertase subtilisin/kexin type 9 (PCSK9) synthesis by RNA interference and has a potent, dose-dependent, durable effect in lowering LDL-C, and therefore is an effective drug to treat dyslipidemia, reducing the risk for acute cardiovascular (CV) events. It is safe and well-tolerated. Areas covered: This paper aims to review the mechanism of action of inclisiran while evaluating its efficacy and safety in the treatment of dyslipidemia from data of the clinical trials in the ORION program. Expert opinion: Data from the clinical trials in the ORION program demonstrated efficacy and safety o…
Lomitapide does not alter PCSK9 and Lp(a) levels in homozygous familial hypercholesterolemia patients: analysis on cytokines and lipid profile
2021
Abstract Lomitapide, a drug for the treatment of homozygous familial hypercholesterolemia patients, reduced total and LDL cholesterol but no significant changes were observed on PCSK9 and Lp(a) plasma levels. Some changes of inflammatory mediators were also observed, including hsCRP, which may suggest an anti-inflammatory effect.
Characterization of microbial communities in pest colonized books by molecular biology tools
2011
This work presents the identification of bacteria and fungi colonies in insect infesting books, by cultural-independent methodologies based on molecular biology techniques. Microbial genomic DNA extraction,<em> in vitro</em> amplification of specific target sequences by polymerase chain reactions (PCR), sequencing and sequence analysis were performed. These procedures minimized the samples amount, optimized the diagnostic studies on bacteria and fungi colonization and allowed the identification of many species also in complex microbial consortia. The molecular techniques for sure accomplish and integrate the microbiological standard methods (<em>in vitro</em>&nbs…
A PC-based wattmeter for high accuracy power measurements
2010
This paper proposes the use of a commercial data acquisition board (DAQ) connected to a common personal computer for high accuracy power measurements. In the paper the set up of the PC-based wattmeter is described and an experimental evaluation of its metrological performances is made by means of the comparison with a simultaneous coherent digital sampling wattmeter realized with two high-precision DMMs Hewlett Packard Model 3458 A. In both cases the power source is a Fluke 6100A/E electrical power standard. © 2010 IEEE.
A DAQ-based sampling wattmeter for IEEE Std. 1459-2010 powers measurements. Uncertainty evaluation in nonsinusoidal conditions
2015
Abstract This paper presents the evaluation of the metrological performances of a DAQ-based sampling wattmeter (DAQ-SW) for the measurement of IEEE Std. 1459-2010 power quantities in non-sinusoidal conditions. The instrument makes use of two commercial data acquisition (DAQ) boards, a non-inductive current shunt, a personal computer and a commercial software for data processing. Starting from the results of an experimental characterization of the two instrument channels with non-sinusoidal voltages and currents and a correlation analysis, the combined standard uncertainties of IEEE Std. 1459-2010 quantities are evaluated, following the approach of the ISO Guide to the Expression of Uncertai…
Development of a high-accuracy PC-based wattmeter with commercial data acquisition boards
2011
This paper presents the development of a high accuracy sampling wattmeter, which makes use of two commercial data acquisition boards (DAQs) connected to a common personal computer. Commercial software is also used for data processing and implementation of the virtual instrument. The set up of the PC-based wattmeter is described and a preliminary evaluation of its metrological performances is made by means of two series of experimental tests, which were carried out with an electric power standard and a high performance multifunction calibrator. © 2011 IEEE.
Protective role of glutathione addition against wine-related stress in Oenococcus oeni
2016
FIliació URV: SIInclòs a la memòria: SI Oenococcus oeni is the main species responsible for the malolactic fermentation (MLF) of wine due to its ability to survive in this environment. Some wine-related stress factors, such as ethanol and low pH, may alter the cell redox balance of O. oeni. For the first time, the ability to uptake glutathione (GSH), an almost universal tripeptide with antioxidant properties, has been associated to the improvement of stress response in O. oeni. Despite the inability of O. oeni to synthesize GSH, this bacterium can capture it from the media. The ability of 30 O. oeni strains to uptake GSH was assessed in this study. Although all of the strains tested were ab…
Real-time PCR detection of Ochroconis lascauxensis involved in the formation of black stains in the Lascaux Cave, France
2012
A real-time Polymerase Chain Reaction (PCR) assay was developed to detect and quantify Ochroconis lascauxensis in the Lascaux Cave in France. This fungus is the principal causal agent of the black stains threatening the Paleolithic paintings of this UNESCO World Heritage Site. The black stains outbreak could not be stopped in spite of using intensive biocide treatments. A sensitive and time-saving protocol is needed for determining the extent of the colonization. Sets of primers that target the ITS and RPB2 regions were designed and evaluated for specificity against O. lascauxensis. Genomic DNA extracted from five species of Ochroconis and 13 other fungal species frequently isolated from ca…
Polarization Modulation Instability in Dispersion-Engineered Photonic Crystal Fibers
2021
Generation of widely spaced polarization modulation instability (PMI) sidebands in a wide collection of photonic crystal fibers (PCF), including liquid-filled PCFs, is reported. The contribution of chromatic dispersion and birefringence to the net linear phase mismatch of PMI is investigated in all-normal dispersion PCFs and in PCFs with one (or two) zero dispersion wavelengths. Large frequency shift sidebands are demonstrated experimentally. Suitable fabrication parameters for air-filled and liquid-filled PCFs are proposed as guidelines for the development of dual-wavelength light sources based on PMI.