Search results for " PROGRESS"
showing 10 items of 1287 documents
Does Obsolescence Matter? The Real Questions of Genetic Enhancement
2019
In his article, Robert Sparrow (2019) builds his arguments on a precondition of rapid technical progress in gene-editing technologies on one hand and on the implication that that gene-editing techn...
Characterization of a novel population of low-density granulocytes associated with disease severity in HIV-1 infection
2012
The mechanisms resulting in progressive immune dysfunction during the chronic phase of HIV infection are not fully understood. We have previously shown that arginase, an enzyme with potent immunosuppressive properties, is increased in HIV seropositive (HIV+) patients with low CD4(+) T cell counts. Here we show that the cells expressing arginase in peripheral blood mononuclear cells of HIV+ patients are low-density granulocytes (LDGs) and that whereas these cells have a similar morphology to normal-density granulocyte, they are phenotypically different. Importantly, our results reveal that increased frequencies of LDGs correlate with disease severity in HIV+ patients.
EUGENICS AND SOCIALIST THOUGHT IN THE PROGRESSIVE ERA: THE CASE OF JAMES MEDBERY MACKAYE
2018
The aim of this essay is to assess James Medbery MacKaye’s contribution to socialist thought during the Progressive Era. Largely forgotten today, MacKaye proposed a special version of socialism, which he called “Pantocracy,” based on a peculiar blend of utilitarian and eugenic assumptions. Specifically, MacKaye held that biological fitness mapped to the capacity for happiness—biologically superior individuals possess a greater capacity for happiness—and saw the eugenic breeding of “a being or race of beings capable in the first place of happiness” as a possibility open by the advent of Pantocracy. Incidentally, this essay provides further evidence that the influence of eugenic and racialist…
Global Initiative for Asthma (GINA) Strategy 2021 - Executive summary and rationale for key changes
2021
Funder: Global Initiative for Asthma
Recommendations for eye care during the alarm state by the coronavirus disease pandemic COVID-19.
2020
Abstract Objective Minimize exposure to the SARS-CoV-2, reduce the chances of cross-transmission between patients and healthcare personnel, and prevent the development of postoperative complications from the management of patients with eye diseases during the 2019 coronavirus disease pandemic (COVID-19). Methods COVID-19 literature review and consensus establishment between different Spanish ophthalmology societies in order to provide guidelines and recommendations of maximum resources primarily conditioned by the state of alert, confinement and social distancing that occurs in Spain since March 16, 2020. Results The recommendations will promote the adoption of action and protection measure…
Defective apoptosis and tumorigenesis: role of p53 mutation and Fas/FasL system dysregulation
2010
The transcription factor p53 and the cytokine receptor FasL are two of the most famous regulators of cell life, and their alterations can cause a large number of pathologies, including cancer. In this review, we focused on how they can determine defective apoptosis, one of the causes of tumorigenesis and tumor progression. The importance of this knowledge lies in the new perspectives that gene therapy can offer to cure cancer.
DEVELOPMENT OF LATVIAN AUTO ROADS AND ADMINISTRATIVE SYSTEM IMPROVEMENT
2012
Auto road sector in national economy, is a sector development of which, with appropriate funding, creates basis for other sector development and facilitates competitiveness of country in international market. The goal of auto road sector is auto road network maintenance and development, in order to contribute to the development of the whole country, increase of standards of living of inhabitants, as well as facilitate compliance of Latvian auto roads with the European Union requirements for auto road network. Effective resource utilization and investment attraction to auto road sector is determinant for favorable conditions to overcome economic crisis, structural changes in national econom…
The History of European Infrastructure Finance: An Analytical Framework
2016
How can socio-economic resources be mobilized to pay for works that offer benefits only in the future, often in the distant future? We discuss what we understand by infrastructure, a term that can have different meanings/semantic contents, and whose definition issues reveal some recurrent conceptual problems. Finance is here understood in the very broad sense of a set of mechanisms bringing to investment, and future benefits, the resources needed in advance to pay for it. We offer a brief discussion of technological and organizational change, as several of our examples and other literature that we cite show that investment and finance decisions are deeply interwoven with knowledge, manageme…
Staging systems in bipolar disorder: an International Society for Bipolar Disorders Task Force Report
2014
Objective: We discuss the rationale behind staging systems described specifically for bipolar disorders. Current applications, future directions and research gaps in clinical staging models for bipolar disorders are outlined. Method: We reviewed the literature pertaining to bipolar disorders, focusing on the first episode onwards. We systematically searched data on staging models for bipolar disorders and allied studies that could inform the concept of staging. Results: We report on several dimensions that are relevant to staging concepts in bipolar disorder. We consider whether staging offers a refinement to current diagnoses by reviewing clinical studies of treatment and functioning and t…
The Influence of Infective Dose on the Virulence of a Generalist Pathogen in Rainbow Trout (Oncorhynchus mykiss) and Zebra Fish (Danio rerio)
2015
Pathogen density and genetic diversity fluctuate in the outside-host environment during and between epidemics, affecting disease emergence and the severity and probability of infections. Although the importance of these factors for pathogen virulence and infection probability has been acknowledged, their interactive effects are not well understood. We studied how an infective dose in an environmentally transmitted opportunistic fish pathogen, Flavobacterium columnare, affects its virulence both in rainbow trout, which are frequently infected at fish farms, and in zebra fish, a host that is not naturally infected by F. columnare. We used previously isolated strains of confirmed high and low …