Search results for " PROGRESS"
showing 10 items of 1287 documents
B-type natriuretic peptide trend predicts clinical significance of worsening renal function in acute heart failure
2019
Aims In acute heart failure (AHF), relationships between changes in B-type natriuretic peptide (BNP) and worsening renal function (WRF) and its prognostic implications have not been fully determined. We investigated the relationship between WRF and a decrease in BNP with in-hospital and 1-year mortality in AHF. Methods and results The Acute Kidney Injury NGAL Evaluation of Symptomatic heart faIlure Study (AKINESIS) was a prospective, international, multicentre study of AHF patients. Severe WRF (sWRF) was a sustained increase of >= 44.2 mu mol/L (0.5 mg/dL) or >= 50% in creatinine, non-severe WRF (nsWRF) was a non-sustained increase of >= 26.5 mu mol/L (0.3 mg/dL) or >= 50% in cr…
Improving extracellular vesicles visualization: From static to motion
2020
AbstractIn the last decade, extracellular vesicles (EVs) have become a hot topic. The findings on EVs content and effects have made them a major field of interest in cancer research. EVs, are able to be internalized through integrins expressed in parental cells, in a tissue specific manner, as a key step of cancer progression and pre-metastatic niche formation. However, this specificity might lead to new opportunities in cancer treatment by using EVs as devices for drug delivery. For future applications of EVs in cancer, improved protocols and methods for EVs isolation and visualization are required. Our group has put efforts on developing a protocol able to track the EVs for in vivo intern…
“I Learned It through the Grapevine…”: Exploring Atypical Ecosystems in Schools as a New Out-of-School Learning Site
2017
Ecology may be seen as one of the main topics of biological education as it functions at the interface of several other aspects of biology. Although it may easily be conveyed through field trips and hands-on activities, it is taught theoretically most of the time and in traditional ecosystems like forests or lakes. For this study, new teaching material has been developed that demonstrates the exploration of more special or “atypical” ecosystems in biology classes. It combines working in a local vineyard with hands-on elements for school. By exploring a human-made ecosystem, which is different from those traditionally used, students gain content knowledge and get to know scientific methods. …
Combined inguinal hernia in the elderly. Portraying the progression of hernia disease
2016
Abstract Introduction Identification of a combined hernia is a common occurrence in the course of inguinal hernia repair. This type of protrusion disease seems to affect the elderly, in particular. Very few investigations have been carried out to ascertain the structural changes that occur in the groin affected by this clinical condition. Method Analysis of intraoperative findings of combined inguinal hernias evidenced in the elderly, from the most recent 100 groin hernia repair procedures carried out by a single operator, represents the basis of the article. Protrusions that presumably represent the forerunner of this type of hernia were also analyzed: double ipsilateral inguinal hernias c…
Kant’s Idea of History
2016
Is there a philosophy of history in Kant’s work? What does “philosophy of history” mean in relation to Kant? In what sense can one use this expression, especially in relation to the Kantian concept of philosophy? The essay tries to answer these questions examining the relationship between biology, progress and political order in Kant's rational reading of human events.
La questione del soprasensibile nella Preisschrift sui progressi della metafisica di Immanuel Kant
2011
Questo saggio intende mettere in evidenza, a partire da una lettura della Preisschrift über die Fortschritte der Metaphysik, il senso architettonico che la metafisica assume in Kant: la metafisica non lega la sua prestazione più eminente al possesso dogmatico di un dominio, sia esso quello teoretico degli oggetti della natura o anche quello pratico degli oggetti della morale, ma alla possibilità di illuminare la strada per il passaggio dall'uno all'altro ambito del conoscere, in una prospettiva critica che, se da un lato mette in rilievo i pericoli insiti negli eccessi dogmatici della ragione, dall'altro ricusa tuttavia l'idea di una metafisica del soprasensibile concepita sotto il segno di…
Expression of a dominant negative type II TGF-β receptor in mouse skin results in an increase in carcinoma incidence and an acceleration of carcinoma…
1998
The role of Transforming growth factor beta (TGF-beta) in carcinogenesis is complex. There are reports on both tumor inhibition and tumor promotion by TGF-beta. To elucidate the complex role of TGF-beta in epithelial carcinogenesis, we generated transgenic mice overexpressing a dominant negative type II TGF-beta receptor in the basal cell compartment and in follicular cells of the skin. Despite the reduced responsiveness of transgenic keratinocytes to TGF-beta, both proliferation and differentiation were normal in non-irritated epidermis of these transgenic mice. Thus, interruption of signaling of all three isoforms of TGF-beta in basal and follicular cells does not disturb tissue homeostas…
Biochemical biomarkers alterations in Coronavirus Disease 2019 (COVID-19)
2020
Abstract Coronavirus Disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a respiratory disease, which can evolve into multi-organ failure (MOF), leading to death. Several biochemical alterations have been described in COVID-19 patients. To date, many biomarkers reflecting the main pathophysiological characteristics of the disease have been identified and associated with the risk of developing severe disease. Lymphopenia represents the hallmark of the disease, and it can be detected since the early stage of infection. Increased levels of several inflammatory biomarkers, including c-reactive protein, have been found in COVID-19 patients and associ…
Value of Deoxyribonucleic Acid Ploidy and Nuclear Morphometry for Prediction of Disease Progression in Renal Cell Carcinoma
1996
AbstractPurpose: A retrospective study was performed on 108 patients with localized renal cell carcinoma (pT1 to 3a N0M0) to determine whether ploidy and nuclear morphometry are independent predictive factors in addition to stage and grade.Materials and Methods: Deoxyribonucleic acid (DNA) content was analyzed by flow cytometry and nuclear morphometry characterized by 5 nuclear descriptors. A Cox proportional hazards regression model was used to identify significant prognostic factors for disease progression.Results: A model combining tumor stage and grade, DNA ploidy and nuclear minor axis was chosen as optimal with risk of disease progression increased with increasing tumor stage and grad…
PeerLA - Assistant for Individual Learning Goals and Self-Regulation Competency Improvement in Online Learning Scenarios
2016
While online learning is already a part of university education and didactics, not all students have the necessary self-regulation competency to really learn on their own efficiently and effectively. In classroom a teacher can take over a moderating part, set intermediate goals and give feedback to one's progress, but participants of online learning courses (e.g. in blended scenarios or Massive Open Online Courses (MOOCs)) face a higher demand of self-regulation competency. This paper presents a course and content independent assistant, PeerLA, which assists in improving self-regulation competency. PeerLA allows setting of long-term goals, breakdown into intermediate goals and keeps track o…