Search results for " PROGRESS"
showing 10 items of 1287 documents
Definitions for response and progression in ovarian cancer clinical trials incorporating RECIST 1.1 and CA 125 agreed by the Gynecological Cancer Int…
2011
The Gynecological Cancer Intergroup (GCIG) has previously reached consensus regarding the criteria that should be used in clinical trial protocols to define progression-free survival after first-line therapy as well as the criteria to define response to treatment in recurrent disease using the serum marker CA 125 and has specified the situations where these criteria should be used. However, the publications did not include detailed definitions, nor were they written to accommodate the new version of Response Evaluation Criteria In Solid Tumors (RECIST) criteria (version 1.1) now available. Thus, we recommend that the definitions described later in detail are incorporated into clinical trial…
Prognostic markers in low-grade papillary urothelial neoplasms of the urinary bladder
2005
Summary Papillary urothelial neoplasms (PUNs) of the urinary bladder comprise a heterogeneous spectrum of ‘continuous' lesions in which the assessment of an accurate histological grade and tumor stage is necessary for an adequate clinical management of patients. Recently, the 1998 World Health Organization/International Society of Urologic Pathologists (WHO/ISUP) Consensus Classification and the 1999 WHO classification proposed a new malignancy grading scheme based mainly on morphometric studies. In accordance with these grading systems, two major categories of PUNs were distinguished: low-grade and high-grade. Concerning the specific subgroup of low-grade tumors two other entities were def…
The Zollinger-Ellison syndrome: is there a role for somatostatin analogues in the treatment of the gastrinoma?
2018
Purpose: Analyze the role of somatostatin analogues (SSAs) in the treatment of sporadic and MEN1-related gastrinomas, trying to define whether recent trials have changed the landscape of gastrinoma therapy. Methods: We evaluate the rationale of SSA use in the treatment of gastrinomas, summarize the current literature concerning the effect of SSAs on the control of Zollinger-Ellison syndrome (ZES) and gastrinomas tumor progression and discuss their role in the most recent guidelines. Results: The medical treatment of gastrinoma and related ZES is aimed at controlling acid hypersecretion and tumor progression, in inoperable patients. The use of proton pump inhibitors (PPIs) to control the syn…
Lack of everolimus diffusion in pleural fluid during pleural progression of breast cancer: A case report
2020
Background We report here a case where no everolimus pleural diffusion was evidenced at the same time of pleural progression of a metastatic breast cancer treated with everolimus and exemestane. Case description A 69-year-old woman was diagnosed in October 2006 with stage III invasive ductal breast adenocarcinoma. After nine months of everolimus and exemestane treatment, she presented with a pleural progression. Everolimus concentration was measured in blood and in pleural fluid. Residual blood concentration was at 9.1 ng/mL, while no everolimus was observed in the pleural fluid. Management and outcome Due to inefficacy of everolimus in this patient, she was switched to palbociclib and fulv…
Transition to secondary progression in relapsing-onset multiple sclerosis: Definitions and risk factors
2021
Background: No uniform criteria for a sensitive identification of the transition from relapsing–remitting multiple sclerosis (MS) to secondary-progressive multiple sclerosis (SPMS) are available. Objective: To compare risk factors of SPMS using two definitions: one based on the neurologist judgment (ND) and an objective data-driven algorithm (DDA). Methods: Relapsing-onset MS patients ( n = 19,318) were extracted from the Italian MS Registry. Risk factors for SPMS and for reaching irreversible Expanded Disability Status Scale (EDSS) 6.0, after SP transition, were estimated using multivariable Cox regression models. Results: SPMS identified by the DDA ( n = 2343, 12.1%) were older, more disa…
Prognostic Impact of Immune Microenvironment Markers in Tumor and Stroma in Resectable Nsclc
2014
ABSTRACT Aim: Tumor-infiltrating immune cells have been proved to play an important role in tumor progression. In this study we have analyzed the expression of 11 immune related genes in both tumor and stroma samples of resectable NSCLC patients. Methods: In this retrospective study FFPE samples from 117 early-stage NSCLC patients of primary tumor tissue were used. The most representative areas of tumor and tumor stroma of each sample were carefully micro-dissected. RT-PCR using hydrolysis probes (TaqMan, Applied Biosystems) was performed to assess the expression of Treg markers such as: CD127, CD25, FOXP3, CTLA-4, IL-10, TGFB-1, LAG-3, GITR and TNFA as well as CD4 and CD8. Relative gene ex…
From World3 to the Social Assessment of Technology: Remarks on Science, Technology, and Society
1993
From a well-known point of view, science is thought to constitute a world of objective entities (World3) different from the objective world of material things (World 1) and the subjective world of minds or mental states (World2). This is an old trichotomy, of which Popper is the leading contemporary proponent.
A review of DEA models when the internal structure of the decision making units is considered
2005
Classical Data Envelopment Analysis (DEA) models consider each Decision Making Unit (DMU), whose relative efficiency they evaluate, as a "black box", i.e., its internal structure is disregarded. The paper presents a comprehensive framework of the most advanced theoretical findings in DEA when the internal structure of the. DMUs is taken into account, thus giving directions for novel applications of such methodology and introducing it as a powerful toot for complex processes performance evaluation.
24M Progress Report. Period concerning this report: 01.01.2019-31.12.2019.
2019
During the second year of the project the main purpose was to design and develop smart fibre-reinforced plastic (FRP) plate by using the most environmentally stable nanocomposite (NC) configuration. As a result, within the support of collaboration partner Institute for Polymers, Composites and Biomaterials (IPCB, Portici, Italy) during Mobility#4 four basalt FRP plates were produced: two [0]8 plates impregnated with the epoxy or the NC, and two [0/45/90/-45]2 also impregnated with the epoxy or the NC, and two [0/45/90/-45]2. Additionally, a set of the specimens for the epoxy and epoxy filled with 0.1 wt.% of hybrid nanofiller (carbon nanotubes and nanofibers in the ratio 1:1) was developed …
Gardens on Canvas and Paper: Cataloguing Botanical Abundance in Late Medici Tuscany
2016
What is the purpose of portraying a branch from a pear tree in bloom and fruit, of listing hundreds of citrus varieties or of dissecting a huge truffle? When Cosimo III (1642–1723), the penultimate grand duke of the Medici dynasty, commissioned artists and botanists alike to create comprehensive visual and textual catalogues of Tuscan flora, aesthetics and curiosity seemed to go hand in hand with a demonstration of knowledge and prosperity. This article deals with the collection of botanical paintings by Bartolomeo Bimbi (1648–1730), housed in the Casino della Topaia close to the city of Florence, and with the mainly handwritten work of the grand ducal botanist Pier Antonio Micheli (1679–17…