Search results for " Parkinson Disease"

showing 7 items of 27 documents

Surgery of Parkinson's disease. Experience in Messina

2003

No abstract

Parkinson disease DBSParkinson disease DBS movement disordersItalyElectric Stimulation Therapy; Humans; Italy; Neurosurgical Procedures; Parkinson DiseaseSettore MED/27 - NeurochirurgiaHumansElectric Stimulation TherapyParkinson DiseaseNeurosurgical Procedures
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Early DEtection of wEaring off in Parkinson disease: The DEEP study

2014

Assessing the frequency of Wearing-Off (WO) in Parkinson's disease (PD) patients, and its impact on Quality of Life (QoL). METHODS: Consecutive ambulatory patients, who were on dopaminergic treatment for ≥ 1 year, were included in this multicentre, observational cross-sectional study. In a single visit, WO was diagnosed based on neurologist assessment as well as using the validated Italian version of a patient self-rated 19-question Wearing-Off Questionnaire (WOQ-19); WO was defined for scores ≥ 2. QoL was evaluated by the 8-item Parkinson's Disease Questionnaire (PDQ-8). RESULTS: 617 subjects were included, with a mean anti-Parkinson treatment duration of 6.6 ± 4.6 years, 87.2% were on lev…

QuestionnairesAdultMaleQuality of lifeLevodopamedicine.medical_specialtyPediatricsParkinson's diseaseTreatment durationParkinson's diseaseEarly detectionDiseaseLevodopaAntiparkinson AgentsQuality of lifeSurveys and Questionnairesmedicine80 and overHumansWearing-offAgedAged 80 and overParkinson's disease; Quality of life; Wearing-off; Wearing-off questionnairebusiness.industryParkinson DiseaseParkinson's disease; quality of life; wearing-off; wearing-off questionnaireMiddle Agedmedicine.diseaseLevodopa; Questionnaires; Parkinson's disease; Humans; Wearing-off; Quality of Life; Aged; Antiparkinson Agents; Cross-Sectional Studies; Wearing-off questionnaire; Parkinson Disease; Aged 80 and over; Adult; Middle Aged; Male; Female; Quality of lifeCross-Sectional StudiesNeurologyAmbulatoryPhysical therapyWearing-off questionnaireObservational studyFemaleSettore MED/26 - NeurologiaNeurology (clinical)Geriatrics and Gerontologybusinessmedicine.drug
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A European Observational Study to Evaluate the Safety and the Effectiveness of Safinamide in Routine Clinical Practice: The SYNAPSES Trial

2021

Background: Safinamide modulates both dopaminergic and glutamatergic systems with positive effects on motor and non-motor symptoms of Parkinson's disease (PD). The drug utilization study SYNAPSES was designed to investigate the use of safinamide in routine clinical practice, as recommended by the European Medicines Agency. Objective: To describe the occurrence of adverse events in PD patients treated with safinamide in real-life conditions. Methods: The SYNAPSES trial is an observational, European, multicenter, retrospective-prospective cohort study. Patients were followed up to 12 months with analyses performed in the overall population and in patients aged >75 years, with relevant comorbi…

Research ReportMale0301 basic medicineBenzylaminesParkinson's diseaseOutcome AssessmentParkinson's diseaseComorbidityDiseaseReal-life evaluationchemistry.chemical_compound0302 clinical medicineOutcome Assessment Health Care80 and overMAO-B inhibitorAged 80 and overSafinamideeducation.field_of_studyAlanineMental DisordersParkinson DiseaseMiddle AgedMAO-B inhibitor; Parkinson's disease; Real-life evaluation; Safinamide; Aged; Aged 80 and over; Alanine; Benzylamines; Comorbidity; Drug-Related Side Effects and Adverse Reactions; Europe; Female; Follow-Up Studies; Humans; Male; Mental Disorders; Middle Aged; Monoamine Oxidase Inhibitors; Parkinson Disease; Retrospective Studies; Outcome Assessment Health CareEuropeSettore MED/26 - NEUROLOGIAFemaleErratumCohort studymedicine.medical_specialtyMonoamine Oxidase InhibitorsDrug-Related Side Effects and Adverse ReactionsPopulationMEDLINE03 medical and health sciencesCellular and Molecular NeuroscienceSafinamideInternal medicinemedicineHumansAdverse effecteducationAgedRetrospective Studiesbusiness.industryMAO-B inhibitor; Parkinson's disease; Real-life evaluation; Safinamidemedicine.diseaseHealth Care030104 developmental biologychemistryParkinson’s diseaseObservational studyNeurology (clinical)business030217 neurology & neurosurgeryFollow-Up StudiesJournal of Parkinson's Disease
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Transbuccal delivery of l-dopa methyl ester: ex vivo permeation studies

2012

Settore CHIM/09 - Farmaceutico Tecnologico ApplicativoL-DOPA methyl ester BUCCAL DELIVERY Parkinson Disease Porcine Buccal Mucosa Ex vivo permeation model
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Frequency of cognitive impairment and factors associated in outpatients with Parkinson’s disease

2011

cognitive impairment Parkinson diseaseSettore MED/26 - Neurologia
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Memory for time intervals is impaired in left hemi-Parkinson patients.

2004

The basal ganglia have been proposed as one of the neural correlates of timekeeping functions. Both encoding and memory retrieval components for time perception are impaired in Parkinson's disease (PD). The aim of our study was to investigate in hemi-Parkinsonian patients the existence of a specific alteration in memory for time depending on the affected side, to better understand the contribution of the left or right basal ganglia circuits in different components of time perception. Right and left hemi-PD patients performed a time reproduction task in which they were required to reproduce in the same session short (5 s) and long (15 s) time intervals, in off- and on-therapy condition. Whil…

endocrine systemmedicine.medical_specialtyParkinson's diseaseTime FactorsParkinson's diseaseCognitive NeuroscienceHemi-Parkinsonian patientsTime perceptionTime perception Parkinson's disease Memory Migration effect Cognitive functions Hemi-Parkinsonian patients Basal gangliaExperimental and Cognitive PsychologyAudiologyFunctional LateralityNOAntiparkinson AgentsLevodopaBehavioral NeuroscienceMemoryBasal gangliaTask Performance and AnalysismedicineHumansLevodopa; Analysis of Variance; Parkinson Disease; Humans; Task Performance and Analysis; Antiparkinson Agents; Aged; Middle Aged; Time Factors; Memory Disorders; Functional Laterality; FemaleMemory disorderAgedNeural correlates of consciousnessAnalysis of VarianceMemory DisordersSettore M-PSI/02 - Psicobiologia E Psicologia FisiologicaMemoriaCognitive disorderCognitionParkinson DiseaseBasal ganglia; Cognitive functions; Hemi-Parkinsonian patients; Memory; Migration effect; Parkinson's disease; Time perception;Time perceptionMiddle Agedmedicine.diseaseCognitive functionsBasal gangliaSettore MED/26 - NeurologiaMigration effectFemalePsychologyNeuroscienceNeuropsychologia
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CLINICAL EFFECTS OF DIFFERENT MONTAGES OF TRANSCRANIAL DIRECT CURRENT STIMULATION IN PATIENTS WITH PARKINSON’DISEASE

2014

tDCS Parkinson Disease
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