6533b855fe1ef96bd12b1534
RESEARCH PRODUCT
Memory for time intervals is impaired in left hemi-Parkinson patients.
Livia BrusaGiacomo KochCarlo CaltagironePaolo StanzioneMassimiliano Oliverisubject
endocrine systemmedicine.medical_specialtyParkinson's diseaseTime FactorsParkinson's diseaseCognitive NeuroscienceHemi-Parkinsonian patientsTime perceptionTime perception Parkinson's disease Memory Migration effect Cognitive functions Hemi-Parkinsonian patients Basal gangliaExperimental and Cognitive PsychologyAudiologyFunctional LateralityNOAntiparkinson AgentsLevodopaBehavioral NeuroscienceMemoryBasal gangliaTask Performance and AnalysismedicineHumansLevodopa; Analysis of Variance; Parkinson Disease; Humans; Task Performance and Analysis; Antiparkinson Agents; Aged; Middle Aged; Time Factors; Memory Disorders; Functional Laterality; FemaleMemory disorderAgedNeural correlates of consciousnessAnalysis of VarianceMemory DisordersSettore M-PSI/02 - Psicobiologia E Psicologia FisiologicaMemoriaCognitive disorderCognitionParkinson DiseaseBasal ganglia; Cognitive functions; Hemi-Parkinsonian patients; Memory; Migration effect; Parkinson's disease; Time perception;Time perceptionMiddle Agedmedicine.diseaseCognitive functionsBasal gangliaSettore MED/26 - NeurologiaMigration effectFemalePsychologyNeurosciencedescription
The basal ganglia have been proposed as one of the neural correlates of timekeeping functions. Both encoding and memory retrieval components for time perception are impaired in Parkinson's disease (PD). The aim of our study was to investigate in hemi-Parkinsonian patients the existence of a specific alteration in memory for time depending on the affected side, to better understand the contribution of the left or right basal ganglia circuits in different components of time perception. Right and left hemi-PD patients performed a time reproduction task in which they were required to reproduce in the same session short (5 s) and long (15 s) time intervals, in off- and on-therapy condition. While the right hemi-PD patients overestimated the shorter interval, only the left hemi-PD group showed the memory migration effect, overestimating the shorter and underestimating the longer time intervals. These results argue for a critical involvement of the right basal ganglia in memory retrieval for time intervals, in the range of seconds.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2004-04-19 | Neuropsychologia |