0000000000020907

AUTHOR

Paolo Stanzione

showing 6 related works from this author

Cerebellar magnetic stimulation decreases levodopa-induced dyskinesias in Parkinson disease

2009

BACKGROUND: The neural mechanisms and the circuitry involved in levodopa-induced dyskinesia (LID) are still partially obscure. LID can be considered the consequence of an abnormal pattern or code of activity that originates and is conveyed from the basal ganglia to the thalamus and the cortical motor areas. However, not only striatothalamocortical motor circuits but also other interconnected pathways could be implicated in its pathogenesis. METHODS: In a series of experiments, we applied repetitive transcranial magnetic stimulation (rTMS) over the lateral cerebellum in a group of patients with advanced Parkinson disease, to investigate whether modulation of cerebellothalamocortical circuits…

Dyskinesia Drug-InducedLevodopaCerebellummedicine.medical_treatmentCTBStmSeverity of Illness IndexrehabilitationNOLevodopaNeural PathwaySeverity of Illness Index; Analysis of Variance; Levodopa; Dyskinesia Drug-Induced; Humans; Cerebellum; Aged; Neural Inhibition; Thalamus; Motor Cortex; Parkinson Disease; Evoked Potentials Motor; Neural Pathways; Middle Aged; Neuronal Plasticity; Transcranial Magnetic StimulationThalamusCerebellumNeural PathwaysBasal gangliamedicineHumansEvoked PotentialsThalamuAgedAnalysis of VarianceNeuronal PlasticityDyskinesiaMotor CortexNeural InhibitionParkinson DiseaseMiddle AgedEvoked Potentials MotorTranscranial Magnetic StimulationAged; Analysis of Variance; Cerebellum; Drug-Induced Dyskinesia; Evoked Potentials; Motor; Humans; Levodopa; Middle Aged; Motor Cortex; Neural Inhibition; Neural Pathways; Neuronal Plasticity; Parkinson Disease; Severity of Illness Index; Thalamus; Transcranial Magnetic StimulationTranscranial magnetic stimulationmedicine.anatomical_structureMotorDyskinesiaDrug-Inducedparkinson's diseaseSettore MED/26 - NeurologiaDrug-Induced DyskinesiaNeurology (clinical)Primary motor cortexmedicine.symptomPsychologyNeuroscienceHumanMotor cortexmedicine.drugNeurology
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rTMS of supplementary motor area modulates therapy-induced dyskinesias in Parkinson disease

2005

The neural mechanisms and circuitry involved in levodopa-induced dyskinesia are unclear. Using repetitive transcranial magnetic stimulation (rTMS) over the supplementary motor area (SMA) in a group of patients with advanced Parkinson disease, the authors investigated whether modulation of SMA excitability may result in a modification of a dyskinetic state induced by continuous apomorphine infusion. rTMS at 1 Hz was observed to markedly reduce drug-induced dyskinesias, whereas 5-Hz rTMS induced a slight but not significant increase.

MaleDyskinesia Drug-InducedApomorphinemedicine.medical_treatmentDopamineNeurological disorderNOCentral nervous system diseaseDegenerative diseasemental disordersNeural PathwaysmedicineHumansAgedSupplementary motor areaDyskinesiabusiness.industryDyskinesia Drug-Induced; Treatment Outcome; Male; Middle Aged; Female; Humans; Parkinson Disease; Motor Cortex; Recovery of Function; Apomorphine; Dopamine Agonists; Neural Pathways; Aged; Transcranial Magnetic Stimulation; DopamineMotor CortexParkinson DiseaseRecovery of FunctionMiddle Agedmedicine.diseaseSMA*Transcranial Magnetic Stimulationnervous system diseasesTranscranial magnetic stimulationApomorphinemedicine.anatomical_structureTreatment OutcomeDyskinesiaDrug-InducedDopamine AgonistsFemaleSettore MED/26 - NeurologiaNeurology (clinical)medicine.symptombusinessNeurosciencemedicine.drug
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High-frequency rTMS improves time perception in Parkinson disease.

2004

Patients with Parkinson disease (PD) are impaired in time processing. The authors investigated the effects of high-frequency (5 Hz) repetitive transcranial magnetic stimulation (rTMS) in patients with PD performing a time reproduction task. The authors found significant improvement in time processing induced by rTMS when trains were applied over the right dorsolateral prefrontal cortex (DLPFC) but not over the supplementary motor area, suggesting that the circuit involving the basal ganglia and the DLPFC might constitute the neural network subserving time perception.

MaleTRANSCRANIAL MAGNETIC STIMULATIONCORTEXmedicine.medical_treatmentmedia_common.quotation_subjectFrontal Lobe; Magnetics; Parkinson Disease; Humans; Treatment Outcome; Aged; Time Perception; Middle Aged; Prefrontal Cortex; Perceptual Disorders; Male; FemalePrefrontal CortexDiseasebehavioral disciplines and activitiesNOCentral nervous system diseasePerceptual DisordersMagneticsDegenerative diseasePerceptionmental disordersBasal gangliamedicineHumansmedia_commonAgedSupplementary motor areaSettore M-PSI/02 - Psicobiologia E Psicologia FisiologicaParkinson DiseaseTime perceptionMiddle Agedmedicine.diseaseFrontal LobeTranscranial magnetic stimulationmedicine.anatomical_structureTreatment Outcomenervous systemTime PerceptionSettore MED/26 - NeurologiaFemaleNeurology (clinical)PsychologyNeurosciencepsychological phenomena and processesNeurology
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Memory for time intervals is impaired in left hemi-Parkinson patients.

2004

The basal ganglia have been proposed as one of the neural correlates of timekeeping functions. Both encoding and memory retrieval components for time perception are impaired in Parkinson's disease (PD). The aim of our study was to investigate in hemi-Parkinsonian patients the existence of a specific alteration in memory for time depending on the affected side, to better understand the contribution of the left or right basal ganglia circuits in different components of time perception. Right and left hemi-PD patients performed a time reproduction task in which they were required to reproduce in the same session short (5 s) and long (15 s) time intervals, in off- and on-therapy condition. Whil…

endocrine systemmedicine.medical_specialtyParkinson's diseaseTime FactorsParkinson's diseaseCognitive NeuroscienceHemi-Parkinsonian patientsTime perceptionTime perception Parkinson's disease Memory Migration effect Cognitive functions Hemi-Parkinsonian patients Basal gangliaExperimental and Cognitive PsychologyAudiologyFunctional LateralityNOAntiparkinson AgentsLevodopaBehavioral NeuroscienceMemoryBasal gangliaTask Performance and AnalysismedicineHumansLevodopa; Analysis of Variance; Parkinson Disease; Humans; Task Performance and Analysis; Antiparkinson Agents; Aged; Middle Aged; Time Factors; Memory Disorders; Functional Laterality; FemaleMemory disorderAgedNeural correlates of consciousnessAnalysis of VarianceMemory DisordersSettore M-PSI/02 - Psicobiologia E Psicologia FisiologicaMemoriaCognitive disorderCognitionParkinson DiseaseBasal ganglia; Cognitive functions; Hemi-Parkinsonian patients; Memory; Migration effect; Parkinson's disease; Time perception;Time perceptionMiddle Agedmedicine.diseaseCognitive functionsBasal gangliaSettore MED/26 - NeurologiaMigration effectFemalePsychologyNeuroscienceNeuropsychologia
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Subthalamic deep brain stimulation improves time perception in Parkinson's disease.

2004

Alterations in temporal estimation have been observed in Parkinson's disease (PD) and have been associated with dopaminergic dysfunction. To investigate whether deep brain stimulation might reverse these abnormalities in PD, patients treated with electrode implantation for subthalamic deep brain stimulation were required to reproduce time intervals in different experimental conditions (off deep brain stimulation/off therapy, on deep brain stimulation/off therapy, on therapy/off deep brain stimulation). Patients treated with deep brain stimulation in off deep brain stimulation/off therapy displayed the anomalous pattern of responses typically observed in PD. When subthalamic deep brain stimu…

MaleDeep brain stimulationParkinson's diseaseDeep brain stimulation; Memory; Parkinsons disease; Time perception;Parkinson's diseasemedicine.medical_treatmentCentral nervous systemElectric Stimulation TherapyNOmemoryParkinsons diseaseBasal gangliamedicineHumansAnalysis of Variance; Parkinson Disease; Humans; Electric Stimulation Therapy; Time Perception; Aged; Middle Aged; Subthalamus; Male; FemaleDeep transcranial magnetic stimulationPrefrontal cortexAgedAnalysis of VarianceSettore M-PSI/02 - Psicobiologia E Psicologia Fisiologicabusiness.industryGeneral NeuroscienceDopaminergicParkinson DiseaseTime perceptionMiddle Agedmedicine.diseasedeep brain stimulationmedicine.anatomical_structureSubthalamusTime PerceptionSettore MED/26 - NeurologiaFemalebusinessNeuroscienceNeuroreport
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Acute inactivation of the medial forebrain bundle imposes oscillations in the SNr: a challenge for the 6-OHDA model?

2010

It has been recently shown that the substantia nigra pars reticulata (SNr) of 6-hydroxydopamine (6-OHDA)-lesioned rats, under urethane anaesthesia, manifests a prominent low frequency oscillation (LFO) of around 1Hz, synchronized with cortical slow wave activity (SWA). Nevertheless, it is poorly understood whether these electrophysiological alterations are correlated only with severe dopamine depletion or may also play a relevant pathogenetic role in the early stages of the dopamine denervation. Hence, here we recorded SNr single units and electrocorticogram (ECoG) in two models of dopamine denervation: (i) acute dopamine denervated rats, obtained by injection of tetrodotoxin (TTX), (ii) ch…

MaleTyrosine 3-Monooxygenasebasal ganglia oscillationsDopamineParkinson's diseaseWistarAction PotentialsParkinson's disease; Low frequency oscillation basal ganglia oscillations; Medial forebrain bundle; Tetrodotoxin; ElectrocorticogramTetrodotoxinSettore BIO/09 - FisiologiaParkinson's disease; low frequency oscillation; basal ganglia oscillations; medial forebrain bundle; Tetrodotoxin; electrocorticogramStatistics NonparametricAnimals; Analysis of Variance; Action Potentials; Electrophysiology; Tyrosine 3-Monooxygenase; Cerebral Cortex; Rats; Biological Clocks; Dopamine; Neurons; Rats Wistar; Substantia Nigra; Immunohistochemistry; Medial Forebrain Bundle; Statistics Nonparametric; MaleMedial forebrain bundlechemistry.chemical_compoundDevelopmental NeuroscienceBiological ClocksDopamineBasal gangliamedicineAnimalsNonparametricRats WistarMedial forebrain bundleElectrocorticographyCerebral CortexNeuronsDenervationAnalysis of Variancemedicine.diagnostic_testChemistryStatisticsLow frequency oscillation basal ganglia oscillationElectrocorticogramImmunohistochemistryRatsCortex (botany)ElectrophysiologySubstantia NigraElectrophysiologynervous systemNeurologylow frequency oscillationTetrodotoxinSettore MED/26 - NeurologiaNeurosciencemedicine.drug
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