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RESEARCH PRODUCT
Subthalamic deep brain stimulation improves time perception in Parkinson's disease.
Giacomo KochPietro TiraboschiCarlo CaltagironePaolo StanzioneAntonella PeppeMassimiliano OliveriLivia Brusasubject
MaleDeep brain stimulationParkinson's diseaseDeep brain stimulation; Memory; Parkinsons disease; Time perception;Parkinson's diseasemedicine.medical_treatmentCentral nervous systemElectric Stimulation TherapyNOmemoryParkinsons diseaseBasal gangliamedicineHumansAnalysis of Variance; Parkinson Disease; Humans; Electric Stimulation Therapy; Time Perception; Aged; Middle Aged; Subthalamus; Male; FemaleDeep transcranial magnetic stimulationPrefrontal cortexAgedAnalysis of VarianceSettore M-PSI/02 - Psicobiologia E Psicologia Fisiologicabusiness.industryGeneral NeuroscienceDopaminergicParkinson DiseaseTime perceptionMiddle Agedmedicine.diseasedeep brain stimulationmedicine.anatomical_structureSubthalamusTime PerceptionSettore MED/26 - NeurologiaFemalebusinessNeurosciencedescription
Alterations in temporal estimation have been observed in Parkinson's disease (PD) and have been associated with dopaminergic dysfunction. To investigate whether deep brain stimulation might reverse these abnormalities in PD, patients treated with electrode implantation for subthalamic deep brain stimulation were required to reproduce time intervals in different experimental conditions (off deep brain stimulation/off therapy, on deep brain stimulation/off therapy, on therapy/off deep brain stimulation). Patients treated with deep brain stimulation in off deep brain stimulation/off therapy displayed the anomalous pattern of responses typically observed in PD. When subthalamic deep brain stimulation was turned on these abnormalities were significantly attenuated. Our findings reveal that subthalamic deep brain stimulation improves time perception in PD patients, supporting the critical role of basal ganglia in this cognitive function, probably mediated by facilitated thalamo-cortical projections to the prefrontal cortex.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2004-01-01 | Neuroreport |