Search results for " Partial"
showing 10 items of 356 documents
Epileptic seizures and cerebrovascular disease
1989
- A series of 88 patients with completed stroke was selected in which heralding, early and late seizures were distinguished according to their onset. Relationships between CT scan and clinical EEG data are discussed with particular emphasis on possible mechanisms of seizures. Thus, small emboli or haemodynamic factors are stressed in the cases of heralding seizures, metabolic disturbances with cytotoxic effects in early seizures and chronic epileptic focus in late seizures.
The CD34 epitope is expressed in neoplastic and malformative lesions associated with chronic, focal epilepsies.
1999
The etiology and pathogenesis of complex focal lesions associated with chronic, intractable epilepsy are largely unknown. Some data indicate that malformative changes of the central nervous system may preceed the development of gangliogliomas and other epilepsy-associated neoplasms. In the present immunhistochemical study, we have examined epilepsy-associated lesions for CD34, a stem cell marker transiently expressed during early neurulation. Surprisingly, most tissue samples from patients with chronic epilepsy (n = 262) revealed neural cells immunoreactive for CD34. Prominent immunoreactivity was detected in gangliogliomas (74%), low-grade astrocytomas (62%) and oligodendrogliomas (59%). O…
The randomized shortened dental arch study (RaSDA): design and protocol
2010
Abstract Background Various treatment options for the prosthetic treatment of jaws where all molars are lost are under discussion. Besides the placement of implants, two main treatment types can be distinguished: replacement of the missing molars with removable dental prostheses and non-replacement of the molars, i.e. preservation of the shortened dental arch. Evidence is lacking regarding the long-term outcome and the clinical performance of these approaches. High treatment costs and the long time required for the treatment impede respective clinical trials. Methods/design This 14-center randomized controlled investigator-initiated trial is ongoing. Last patient out will be in 2010. Patien…
Evidences of cannabinoids-induced modulation of paroxysmal events in an experimental model of partial epilepsy in the rat.
2009
The anticonvulsant effect of cannabinoids (CB) has been shown to be mediated by the activation of the CB(1) receptor. This study evaluates the anticonvulsant activity of (R)-(+)-[2,3-dihydro-5-methyl-3-(4-morpholinylmethyl) pyrrolo[1,2,3-de]-1,4-benzoxazin-6-Yl]-1-naphthalenylmethanone (WIN55,212-2, CB agonist) alone or preceded by the administration of N-(piperidin-1-yl)-5-(4-iodophenyl)-1-(2,4-dichlorophenyl)-4-methyl-1H-pyrazole-3-carboxamide (AM251, selective CB(1) antagonist) in an experimental in vivo model of complex partial seizures (maximal dentate gyrus activation - MDA) in the rat. WIN55,212-2 (21mgkg(-1)) exerted an anticonvulsant effect, significantly reduced by the pre-treatme…
Role of CB2 receptors and cGMP pathway on the cannabinoid-dependent antiepileptic effects in an in vivo model of partial epilepsy.
2014
This study aimed at providing an insight on the possible role of cannabi-noid (CB) type 2 receptors (CB2R) and cGMP pathway in the antiepileptic activity ofWIN 55,212-2, (R)-(+)-[2,3-dihydro-5-methyl-3-(4-morpholinylmethyl) pyrrolo[1,2,3-de]-1,4-benzoxazin-6-Yl]-1-naphthalenylmethanone, a non-selective CB agonist, in the maximal dentate activation (MDA) model of partial epilepsy in adult male rats. We evaluated the activity of a CB2 antagonist/inverse agonist AM630, [6-iodo-2-methyl-1-[2-(4-morpholinyl)ethyl]-1H-indol-3-yl](4-methoxyphenyl)methanone or 6-iodopravadoline, alone or in co-administration with WIN 55,212-2. Also, in the MDA model it was investigated the co-treatment of WIN55,212…
On stability issues for IMEX schemes applied to 1D scalar hyperbolic equations with stiff reaction terms
2011
The application of a Method of Lines to a hyperbolic PDE with source terms gives rise to a system of ODEs containing terms that may have very different stiffness properties. In this case, Implicit-Explicit Runge-Kutta (IMEX-RK) schemes are particularly useful as high order time integrators because they allow an explicit handling of the convective terms, which can be discretized using the highly developed shock capturing technology, together with an implicit treatment of the source terms, necessary for stability reasons. Motivated by the structure of the source term in a model problem introduced by LeVeque and Yee in [J. Comput. Phys. 86 (1990)], in this paper we study the preservation of ce…
Multiplicity results for a class of asymmetric weakly coupled systems of second order ordinary differential equations
2005
We prove the existence and multiplicity of solutions to a two-point boundary value problem associated to a weakly coupled system of asymmetric second-order equations. Applying a classical change of variables, we transform the initial problem into an equivalent problem whose solutions can be characterized by their nodal properties. The proof is developed in the framework of the shooting methods and it is based on some estimates on the rotation numbers associated to each component of the solutions to the equivalent system.
Fixed point theorems for fuzzy mappings and applications to ordinary fuzzy differential equations
2014
Abstract Ran and Reurings (Proc. Am. Math. Soc. 132(5):1435-1443, 2004) proved an analog of the Banach contraction principle in metric spaces endowed with a partial order and discussed some applications to matrix equations. The main novelty in the paper of Ran and Reurings involved combining the ideas in the contraction principle with those in the monotone iterative technique. Motivated by this, we present some common fixed point results for a pair of fuzzy mappings satisfying an almost generalized contractive condition in partially ordered complete metric spaces. Also we give some examples and an application to illustrate our results. MSC:46S40, 47H10, 34A70, 54E50.
The influence of the anatase nanoparticles boundaries on the titania activity performance
2014
Metal oxides structures, formed by ordered self-assembling of crystalline nanoparticles aggregates, are attracting growing attention in fields such as catalysis or solar cells. The properties of these structures are influenced not only by their morphology and nanoparticles composition but also by the assembled particles boundaries. In order to determine the influence of these boundaries on the structures properties, the present investigation has been devoted to study the characteristics of anatase nanoparticles boundaries in titania aggregates prepared by TiCl4 hydrolysis at low temperature. Proton magic angle spinning nuclear magnetic resonance and high resolution transmission electron mic…
Local regularity for quasi-linear parabolic equations in non-divergence form
2018
Abstract We consider viscosity solutions to non-homogeneous degenerate and singular parabolic equations of the p -Laplacian type and in non-divergence form. We provide local Holder and Lipschitz estimates for the solutions. In the degenerate case, we prove the Holder regularity of the gradient. Our study is based on a combination of the method of alternatives and the improvement of flatness estimates.