Search results for " Peritoneal"
showing 10 items of 87 documents
Aroclor 1254 inhibits the chemiluminescence response of peritoneal cavity cells from sharpsnout sea bream (Diplodus puntazzo)
2014
Chronic exposure to polychlorinated biphenyls (PCBs) affect the immune system of fish and could lead to a decreased disease resistance. The effects of Aroclor 1254, PCB mixtures, on the Diplodus puntazzo innate immunity were examined by assaying the zymosan stimulated chemiluminescence response (CL) of peritoneal cavity cells (PCCs) at various times (1, 24, 48 h and 1-4 weeks) from intraperitoneal injection of the xenobiotic (1 mg kg(-1) body weight). Controls were performed by assaying cells from medium-treated fish. Since the kinetic of the chemiluminescence response showed the highest peak at 25 min after the zymosan stimulation of the cells, the values found at that time were considered…
Role of Cytoreductive surgery in recurrent ovarian cancer
2010
Ovarian cancer is the leading cause of death from gynecologic malignancy in western countries, primarily because over 60% of patients with ovarian cancer will experience disease recurrence. Primary cytoreductive surgery and combination chemotherapy are the cornerstones of the initial treatment for epithelial ovarian cancer. The management of recurrent ovarian cancer is less clear than that of primary disease. The management of recurrent ovarian cancer is largely based on systemic chemotherapy, with surgery being offered only in selected individuals. Despite this, the benefits of surgery has been shown in a meta-analysis by Bristow et al. where the survival is influenced by the completeness …
Beryllium-induced disturbances of the murine immune system reflect some phenomena observed in sarcoidosis.
1994
Sarcoidosis is a systemic granulomatous disorder of unknown origin. In respect to clinical and immunological characteristics, it is indistinguishable from berylliosis. As an approach to develop a murine model reflecting some aspects of sarcoidosis, we attempted to induce berylliosis in mice by treating inbred F1 mice (C57B16 x DBA/2) with 3 mg beryllium sulfate (BeSO4) per kg body weight intraperitoneally. Either pure BeSO4 or BeSO4 in combination with incomplete Freund's adjuvant was administered. Alternatively, pure BeSO4 was injected 2 days after a single application of cyclophosphamide (150 mg/kg). The spleen index, the spontaneous and phorbolmyristate acetate (PMA)-induced radical oxyg…
LAAE-14, a new in vitro inhibitor of intracellular calcium mobilization, modulates acute and chronic inflammation.
2003
Abstract A new lipidic acid-amido ether derivative (LAAE-14) able to reduce dose-dependently the calcium increases mediated either by calcium ionophore ionomycin, by the endoplasmic reticular Ca 2+ -ATPase inhibitor thapsigargin, or by the chemotactic tripeptide N -formyl- l -methionyl- l -leucyl- l -phenylalanine (fMLP), in human neutrophils as well as in murine peritoneal macrophages, but not ATP, has been evaluated as a potential anti-inflammatory drug. This compound attenuated leukocyte activation by means of its inhibitory effect on the respiratory burst elicited in both types of cells by 12- O -tetradecanoyl phorbol 13-acetate, by inhibition of the degranulation process induced by cyt…
Prostaglandin E(2)-loaded microspheres as strategy to inhibit phagocytosis and modulate inflammatory mediators release.
2008
PGE(2), an arachidonic acid metabolite produced by various type of cells regulates a broad range of physiological activities in the endocrine, cardiovascular, gastrointestinal, and immune systems, and is involved in maintaining the local homeostasis. In the immune system, PGE(2) is mainly produced by APCs and it can suppress the Th1-mediated immune responses. The aim of this study was to develop PGE(2)-loaded biodegradable MS that prolong and sustain the in vivo release of this mediator. An o/w emulsion solvent extraction-evaporation method was chosen to prepare the MS. We determined their diameters, evaluated the in vitro release of PGE(2), using enzyme immunoassay and MS uptake by periton…
Synthesis and biological evaluation of new imidazo[2,1-b][1,3,4]thiadiazole derivatives: as anticancer and antibiofilm agents, and preclinical invest…
2020
Farmacocinética y farmacodinamia de oxaliplatino intraperitoneal con hipertermia en pacientes con carcinomatoisis peritoneal sometidos a cirugía
2016
La carcinomatosis peritoneal (CP) es la diseminación tumoral, localizada o masiva, que afecta a la serosa del peritoneo y sus órganos vecinos. Esta situación clínica compromete seriamente la vida de los pacientes y su incurabilidad se debe, fundamentalmente, a la ausencia de terapias eficaces y seguras para su tratamiento. Recientemente, se han establecido las bases de un tratamiento multidisciplinar basado en la cirugía radical o citorreducción (CRS), cuyo objetivo es eliminar la enfermedad macroscópica mediante resecciones peritoneales, seguido de la administración de quimioterapia intraperitoneal hipertérmica (HIPEC), con el fin de erradicar el tumor microscópico residual que no puede se…
Estudio comparativo de evaluación de pruebas diagnósticas en la determinación de la distancia al margen anal del cáncer de recto
2015
La localización topográfica exacta de los tumores de recto y sus relaciones individuales con las estructuras anatómicas de la pelvis determinan su estrategia terapéutica multidisciplinar basada en la combinación de radioquimioterapia y cirugía radical con exéresis mesorrectal. Actualmente los métodos diagnósticos basados en instrumentos rígidos o flexibles no siempre se correlacionan con la impresión del cirujano durante el desarrollo de la intervención quirúrgica. Por otro lado la imagen por Resonancia Magnética permite hoy en día un detallado estudio topográfico pélvico fundamental para la estadificación locorregional. El objetivo de nuestro trabajo es comprobar si la Resonancia Magnética…
Localización del cáncer de recto en relación a la reflexión peritoneal. Implicaciones pronósticas.
2021
Introducción La afectación del margen de resección circunferencial (MRC) en la resección de los tumores de recto es uno de los factores principales relacionados con la recidiva local. Sin embargo, los tumores de recto localizados a nivel de la reflexión peritoneal (RP) pueden afectar tanto a la serosa peritoneal (T4a) como a la fascia mesorrectal (MRC afecto). La determinación de la localización de los tumores de recto respecto con la RP y su posible infiltración es un factor a tener en cuenta en la estadificación por sus implicaciones terapéuticas y pronósticas. Objetivo: El objetivo de este estudio es determinar la exactitud de la resonancia magnética (RM) preoperatoria para determinar la…
F-type lectin from the sea bass (Dicentrarchus labrax): purification, cDNA cloning, tissue expression and localization, and opsonic activity.
2009
Recently described biochemical and structural aspects of fucose-binding lectins from the European eel (Anguilla anguilla) and striped bass (Morone saxatilis) led to the identification of a novel lectin family ("F-type" lectins) characterized by a unique sequence motif and a characteristic structural fold. The F-type fold is shared not only with other members of this lectin family, but also with apparently unrelated proteins ranging from prokaryotes to vertebrates. Here we describe the purification, biochemical and molecular properties, and the opsonic activity of an F-type lectin (DlFBL) isolated from sea bass (Dicentrarchus labrax) serum. DlFBL exhibits two tandemly arranged carbohydrate-r…