Search results for " Phase"

Looking for a new panacea in ALK-rearranged NSCLC: may be Ceritinib?

2014

Abstract: In the past decade, the advent of targeted therapy led to a silent revolution in the war against lung cancer and a significant evolution on the concept of Phase I clinical trials design. Thanks to the specificity of their target, the new drugs have radically changed NSCLC treatment, leading to the development of personalized strategies. The accelerated approval of the first ALK-inhibitor, Crizotinib and more recently Ceritinib, without a Phase III randomized, clinical trial, has been an amazing success story in lung cancer research, marking the beginning of a new decade of targeted drugs development, characterized by modern, biomarker-driven, early clinical trial design and shorte…

Cetuximab in squamous cell head and neck carcinomas.

2007

The epidermal growth factor receptor (EGFR) antagonist, cetuximab, has recently been shown to enhance the effects of radiotherapy, and reports to date indicate that this effect occurs without any change in the pattern and severity of toxicity usually associated with head and neck radiation and/or chemotherapy (CT) administration. Moreover, several studies have reported that the expression of EGFR is strongly linked to poor outcome in patients undergoing therapy. Therefore, the presence of the EGFR in almost all cases of head and neck carcinoma offers a new therapeutic opportunity to most patients. In this paper, we report a review of the major studies dealing with the use of cetuximab in ad…

Optimal Power Flow in three-phase islanded microgrids with inverter interfaced units

2015

In this paper, the solution of the Optimal Power Flow (OPF) problem for three phase islanded microgrids is studied, the OPF being one of the core functions of the tertiary regulation level for an AC islanded microgrid with a hierarchical control architecture. The study also aims at evaluating the contextual adjustment of the droop parameters used for primary voltage and frequency regulation of inverter interfaced units. The work proposes a mathematical method for the OPF solution also considering the droop parameters as variables. The output of the OPF provides an iso-frequential operating point for all the generation units and a set of droop parameters for primary regulation. In this way, …

A Rotor Flux and Speed Observer for Sensorless Single-Phase Induction Motor Applications

2012

It is usual to find single-phase induction motor (SPIM) in several house, office, shopping, farm, and industry applications, which are become each time more sophisticated and requiring the development of efficient alternatives to improve the operational performance of this machine. Although the rotor flux and rotational speed are essential variables in order to optimize the operation of a SPIM, the use of conventional sensors to measure them is not a viable option. Thus, the adoption of sensorless strategies is the more reasonable proposal for these cases. This paper presents a rotor flux and rotational speed observer for sensorless applications involving SPIMs. Computer simulations and the…

Instantaneous frequency measurement by in-fiber 0.5th order fractional differentiation

2016

We experimentally demonstrate the possibility to retrieve the instantaneous frequency profile of a given temporal light pulse by in-fiber fractional order differentiation of 0.5th-order. The signal's temporal instantaneous frequency profile is obtained by simple dividing two temporal intensity profiles, namely the intensities of the input and output pulses of a spectrally-shifted fractional order differentiation. The results are supported by the experimental measurement of the instantaneous frequency profile of a mode-locked laser. Fil: Poveda-Wong, L.. Universidad de Valencia; España Fil: Carrascosa, A.. Universidad de Valencia; España Fil: Cuadrado Laborde, Christian Ariel. Consejo Nacion…

An approach to the measurement of the nonlinear refractive index of very short lengths of optical fibers

2018

A method for the measurement of the nonlinear-refractive index coefficient in single-mode optical fibers is presented. It takes advantage of the high sensitivity of the acousto-optic interaction effect in optical fibers to the fiber properties. Direct measurement of the nonlinear-refractive index change resulting from cross-phase modulation between a probe and a pump signal is obtained from the fiber's acousto-optic interaction performance. It is a non-interferometric method in which a very short length of fiber (<0.25 m) is required.

Bounds on transient phase plastic deformations in optimal design of steel frames subjected to cyclic loads

2009

A minimum volume multicriterion design of elastic perfectly plastic steel frames subjected to a combination of quasi-static fixed and cyclic loads, bounding the transient phase plastic deformations, is proposed. The problem is formulated according to a plastic shakedown criterion, so that incremental and instantaneous collapse are certainly prevented when the frame is subjected to very strongly amplified cyclic loads. The further condition that the structure must also behave elastically in serviceability conditions is imposed. Since the steady-state loading history is known it is possible to directly bound the steady-state plastic deformations. By applying a suitable own bounding theorem, i…

OPTIMAL POWER FLOW IN ISLANDED MICROGRIDS

In this thesis, studies about OPF in islanded MGs have been carried out. First, an original formulation and solution approach for the OPF problem in islanded distribution systems is proposed. The methodology is well suited for AC microgrids and can be envisioned as a new hierarchical control structure comprising only two levels: primary and tertiary regulation, the latter also providing iso-frequency operating points for all units and optimized droop parameters for primary regulation. The OPF provides a minimum losses operating point for which voltage drops are limited and power sharing is carried out according to the most adequate physical properties of the infrastructure thus giving rise …

1,3-Dipolar cycloaddition of 1H-pyrazinium-3-olate and N1- and C-methyl substituted pyrazinium-3-olates with methyl acrylate: a density functional th…

2011

Abstract A DFT study of the 1,3-dipolar cycloaddition of methyl acrylate to 1H-pyrazinium-3-olate and N1- and C-methyl substituted pyrazinium-3-olates, in the gas phase and in THF, has been carried out at the B3LYP/6-31G(d) level. Two stereoisomeric pathways, endo and exo, and two regioisomeric channels, 2-oxo-3,8-diazabicyclo[3.2.1]octane-6-ester and 7-ester products, have been considered. Thermodynamic and kinetic parameters calculated at room temperature have been analyzed. The regioselectivity has been interpreted using reactivity indices. It is generally found that the exo pathway is preferred and the formation of the 6-esters is dominant. The theoretical data obtained for the cycloadd…

Improved performance in flexible organic solar cells by using copolymeric phase-separation modulators

2018

One of the main problems related to the low performance of the organic solar cells (OSCs), concerns the low mobility of the materials constituting the heterojunction. Indeed, the poor charge transport in the active layer is the principal cause of a competition between separation and recombination of the photogenerated carriers. In this regard, a major obstacle to enhance OSCs efficiency is developing strategies to optimize the exciton dissociation and, consequently, the charge collection at the electrodes. Donor and acceptor systems must be well mixed on the length scale of 5 – 20 nm (exciton diffusion length) to meet the criteria for efficient exciton dissociation. In addition, the network…