Looking for a new panacea in ALK-rearranged NSCLC: may be Ceritinib?

6533b822fe1ef96bd127d878

RESEARCH PRODUCT

Looking for a new panacea in ALK-rearranged NSCLC: may be Ceritinib?

Francesco Passiglia Patrick Pauwels Antonio Russo Christian Rolfo

subject

Oncology medicine.medical_specialty Pathology Lung Neoplasms Pyridines Settore MED/06 - Oncologia Medica medicine.medical_treatment Clinical Biochemistry EML4-ALK Ceritinib NSCLC Targeted therapy Panacea (medicine)Crizotinib Carcinoma Non-Small-Cell Lung Internal medicine Drug Discovery Humans Medicine Anaplastic Lymphoma Kinase Molecular Targeted Therapy Sulfones Precision Medicine Lung cancer Drug Approval Protein Kinase Inhibitors Gene Rearrangement Pharmacology Ceritinib; Crizotinib; EML4-ALK; NSCLC Clinical Trials Phase I as Topic Crizotinib Ceritinib business.industry Pharmacology. Therapy Clinical study design Receptor Protein-Tyrosine Kinases medicine.disease Ceritinib Crizotinib EML4-ALK NSCLC Clinical trial Pyrimidines Drug Design Pyrazoles Molecular Medicine Accelerated approval business medicine.drug

description

Abstract: In the past decade, the advent of targeted therapy led to a silent revolution in the war against lung cancer and a significant evolution on the concept of Phase I clinical trials design. Thanks to the specificity of their target, the new drugs have radically changed NSCLC treatment, leading to the development of personalized strategies. The accelerated approval of the first ALK-inhibitor, Crizotinib and more recently Ceritinib, without a Phase III randomized, clinical trial, has been an amazing success story in lung cancer research, marking the beginning of a new decade of targeted drugs development, characterized by modern, biomarker-driven, early clinical trial design and shorter times for clinical approval. Is Ceritinib a new panacea for the treatment of ALK-rearranged NSCLC? We aimed to discuss the reasons of such success, including the new emerging questions, regarding mechanisms of acquired resistance, and the best treatment algorithm for ALK-rearranged NSCLC patients.

year	journal	country	edition	language
2014-01-01	Expert Opinion on Therapeutic Targets

https://doi.org/10.1517/14728222.2014.936383

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