Search results for " Plastic"
showing 10 items of 3463 documents
The corticotrophin-releasing factor/urocortin system regulates white fat browning in mice through paracrine mechanisms.
2015
Objectives:\ud The corticotrophin-releasing factor (CRF)/urocortin system is expressed in the adipose tissue of mammals, but its functional role in this tissue remains unknown.\ud \ud Methods:\ud Pharmacological manipulation of the activity of CRF receptors, CRF1 and CRF2, was performed in 3T3L1 white pre-adipocytes and T37i brown pre-adipocytes during in vitro differentiation. The expression of genes of the CRF/urocortin system and of markers of white and brown adipocytes was evaluated along with mitochondrial biogenesis and cellular oxygen consumption. Metabolic evaluation of corticosterone-deficient or supplemented Crhr1-null (Crhr1−/−) mice and their wild-type controls was performed alo…
Toward a link between brain plasticity and satiety
2021
International audience
Proton Exchange Membrane Fuel Cells (PEMFCs): Advances and Challenges
2021
The study of the electrochemical catalyst conversion of renewable electricity and carbon oxides into chemical fuels attracts a great deal of attention by different researchers. The main role of this process is in mitigating the worldwide energy crisis through a closed technological carbon cycle, where chemical fuels, such as hydrogen, are stored and reconverted to electricity via electrochemical reaction processes in fuel cells. The scientific community focuses its efforts on the development of high-performance polymeric membranes together with nanomaterials with high catalytic activity and stability in order to reduce the platinum group metal applied as a cathode to build stacks of proton …
Botulinum Toxin A for Oral Cavity Cancer Patients: In Microsurgical Patients BTX Injections in Major Salivary Glands Temporarily Reduce Salivary Prod…
2012
Abstract: In patients suffering from oral cavity cancer surgical treatment is complex because it is necessary to remove carcinoma and lymph node metastasis (through a radical unilateral or bilateral neck dissection) and to reconstruct the affected area by means of free flaps. The saliva stagnation in the post-operative period is a risk factor with regard to local complications. Minor complications related to saliva stagnation (such as tissue maceration and wound dehiscence) could become major complications compromising the surgery or the reconstructive outcome. In fact the formation of oro-cutaneous fistula may cause infection, failure of the free flap, or the patient’s death with carotid b…
Modulation of plasticity of the soleus area of the motor cortex using paired associative stimulation
2015
Paired associative stimulation (PAS) repeatedly combines single somatosensory nerve stimuli with single transcranial magnetic stimuli to induce bidirectional changes in the excitability of the cortical projections to the target muscle. PAS and motor training have been shown to share common neural mechanisms, suggesting that PAS tests functionally relevant neuronal circuits. While PAS has been used extensively to target the hand area of the motor cortex, few studies have targeted the leg area of the motor cortex. The optimal interstimulus inter- val (ISI) to induce plasticity in the cortical projections to lower limbs is still not well established. Thus, the first purpose of this thesis was …
The effect of paired associative stimulation-induced long-term potentiation-like plasticity on visuomotor learning
2014
Aivojen hermostollisissa rakenteissa ja toiminnassa tapahtuu adaptaatiota motorisen oppimisen seurauksena. Eräs ehdotetuista malleista, johon muutokset voivat perustua on hermoliitoksen voimakkuuden pitkäaikainen tehostuminen eli pitkäkestoinen potentiaa-tio (LTP). Keinotekoisesti LTP:n kaltainen vaikutus voidaan tuottaa parillisella as-sosiatiivisella stimulaatiolla (PAS). Lisäksi tutkimustulokset osoittavat, että PAS voi parantaa tietyn tyyppistä motorista oppimista. Tämän tutkimuksen tarkoituksena on sel-vittää miten PAS:n tuottama LTP:n kaltainen plastisuus vaikuttaa visuomotorisen oppi-misen alkuvaiheeseen. Visuomotorinen oppimistehtävä suoritettiin kolme kertaa PAS:n jälkeen. Oppimist…
Cell Mediated Immune System Hyperactivation and Complications in Surgery. Is There a Correlation?
2010
Introduction: The role of the immune system in wound healing is multifaceted and cell-to-cell interactions may affect healing in several ways, many of which are probably still unknown. The case of a 19-year-old girl who, after multiple postsurgical complications, was found to have a transient immune system hyperactivation is reported. Materials and Methods: A 19-years-old woman with a breast asymmetry, previously treated with breast augmentation and contralateral reduction mammaplasty, had her implant removed and she came to our attention seeking autologous reconstruction. A free DIEP flap was performed and, again, wound breakdown and liponecrosis ensued at both the donor and recipient site…
Melt Processed PCL/PEG Scaffold with Discrete Pore Size Gradient for Selective Cellular Infiltration
2016
In order to develop scaffold able to mimic the natural gradient properties of tissues, biphasic and triphasic approaches were adopted. In this work, polycaprolactone/polyethylene glycol (PCL/PEG) scaffolds were prepared by using a combination of melt mixing and selective leaching without harmful solvents. The method permitted to develop three-layer scaffolds with high control of porosity and pore size. The mechanical properties were evaluated under physiological condition in order to simulate the real conditions of work. Co-culture of osteoblastic and fibroblastic mice cells were carried out in order to study the differential cellular permeation through the different pore size layers.
Induction of neuronal plasticity during adulthood. Role of cortical interneurons and plasticity-related molecules.
2019
La complejidad del sistema nervioso de los vertebrados representa un reto a la hora de conocer su funcionamiento. Hace ya más de cien años que se postuló la neurona como unidad básica de procesamiento, generación y transmisión de la información a través de este sistema, y, con el paso de los años, ha evolucionado el conocimiento sobre esta unidad funcional. La idea clásica del sistema nervioso central (SNC) adulto es la de un tejido asombrosamente interconectado y complejo, pero prácticamente inmutable y muy poco adaptable a los cambios. No obstante, esta visión se ha ido desplazando, formándose una nueva idea del SNC adulto que, aunque de manera más limitada que durante el desarrollo, tamb…
Can Oscillatory Alpha-Gamma Phase-Amplitude Coupling be Used to Understand and Enhance TMS Effects?
2019
Recent applications of simultaneous scalp electroencephalography (EEG) and transcranial magnetic stimulation (TMS) suggest that adapting stimulation to underlying brain states may enhance neuroplastic effects of TMS. It is often assumed that longer-lasting effects of TMS on brain function may be mediated by phasic interactions between TMS pulses and endogenous cortical oscillatory dynamics. The mechanisms by which TMS exerts its neuromodulatory effects, however, remain unknown. Here, we discuss evidence concerning the functional effects on synaptic plasticity of oscillatory cross-frequency coupling in cortical networks as a potential framework for understanding the neuromodulatory effects o…