Search results for " Primary"

showing 10 items of 453 documents

Treatment of multiple sclerosis with rituximab: A multicentric Italian–Swiss experience

2020

Background: Rituximab, an anti-CD20 monoclonal antibody leading to B lymphocyte depletion, is increasingly used as an off-label treatment option for multiple sclerosis (MS). Objective: To investigate the effectiveness and safety of rituximab in relapsing–remitting (RR) and progressive MS. Methods: This is a multicenter, retrospective study on consecutive MS patients treated off-label with rituximab in 22 Italian and 1 Swiss MS centers. Relapse rate, time to first relapse, Expanded Disability Status Scale (EDSS) progression, incidence of adverse events, and radiological outcomes from 2009 to 2019 were analyzed. Results: A total of 355/451 enrolled subjects had at least one follow-up visit an…

Multiple Sclerosismedicine.drug_classLymphocyte depletionrelapsing–remittingMonoclonal antibodyPrimary progressive03 medical and health sciences0302 clinical medicineMultiple Sclerosis Relapsing-Remittingreal lifemedicineHumansImmunologic Factors030212 general & internal medicineSecondary progressiveRetrospective Studiesprimary progressivebusiness.industryMultiple sclerosisRituximab; multiple sclerosis; primary progressive; real life; relapsing–remitting; secondary progressiveTreatment optionsmedicine.diseaseNeurologyRelapsing remittingItalymultiple sclerosiImmunologysecondary progressiveRituximabSettore MED/26 - NeurologiaNeurology (clinical)businessRituximab030217 neurology & neurosurgerySwitzerlandmedicine.drug
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The Root Mycobiota of Betula aetnensis Raf., an Endemic Tree Species Colonizing the Lavas of Mt. Etna (Italy)

2021

Betula aetnensis is an endemic tree of high conservation value, which thrives on the nutrient-poor volcanic soils of Mount Etna. Since plant–microbe interactions could play a crucial role in plant growth, resource uptake, and resistance to abiotic stresses, we aimed to characterize the root and rhizosphere microbial communities. Individuals from natural habitat (NAT) and forest nursery (NURS) were surveyed through microscopy observations and molecular tools: bacterial and fungal automated ribosomal intergenic spacer analysis (ARISA), fungal denaturing gradient gel electrophoresis (DGGE). B. aetnensis was found to be simultaneously colonized by arbuscular (AM), ectomycorrhizal (ECM), ericoid…

MycobiotaLeccinumRibosomal Intergenic Spacer analysisBiologyMediterranean forestsBotanyMediterranean forestQK900-989Plant ecologyPezizalesRhizosphere<i>Oidiodendron</i><i>Betula pendula</i>primary successionfungiOidiodendronForestrybiology.organism_classification<i>Betula pendula</i>; Mediterranean forests; primary succession; <i>Oidiodendron</i>; <i>Phialocephala</i>; mycorrhizal symbiontsRhizopogonHelotiales<i>Phialocephala</i>Betula pendulaPhialocephalamycorrhizal symbiontsTemperature gradient gel electrophoresis
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Expectations, experiences and attitudes of patients and primary care health professionals regarding online psychotherapeutic interventions for depres…

2013

Abstract Background In the year 2020, depression will cause the second highest amount of disability worldwide. One quarter of the population will suffer from depression symptoms at some point in their lives. Mental health services in Western countries are overburdened. Therefore, cost-effective interventions that do not involve mental health services, such as online psychotherapy programs, have been proposed. These programs demonstrate satisfactory outcomes, but the completion rate for patients is low. Health professionals’ attitudes towards this type of psychotherapy are more negative than the attitudes of depressed patients themselves. The aim of this study is to describe the profile of d…

Médicos de atención primariaPsychological interventionActitud ante los ordenadoresActitud ante la salud:Psychiatry and Psychology::Behavior and Behavior Mechanisms::Attitude::Attitude to Computers [Medical Subject Headings]:Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Primates::Haplorhini::Catarrhini::Hominidae::Humans [Medical Subject Headings]DepresionStudy ProtocolCompletion rateProtocol:Health Care::Health Care Quality Access and Evaluation::Delivery of Health Care::Attitude to Health [Medical Subject Headings]Depression (differential diagnoses)Qualitative Researcheducation.field_of_studyOnline psychotherapyEntrevistas como asuntoAttitude to ComputersDepressionGrupos focales:Health Care::Health Care Quality Access and Evaluation::Delivery of Health Care::Attitude of Health Personnel [Medical Subject Headings]TelemedicinaFocus GroupsTelemedicinePsychiatry and Mental health:Health Care::Health Services Administration::Patient Care Management::Delivery of Health Care::Telemedicine [Medical Subject Headings]Attitude to Healthmedicine.medical_specialtyTelemedicineAttitude of Health Personnel:Psychiatry and Psychology::Behavioral Disciplines and Activities::Psychotherapy [Medical Subject Headings]PopulationInternet-based treatmentPhysicians Primary CareInterviews as TopicActitud del personal sanitariomedicineHumansPsychiatryeducationbusiness.industry:Analytical Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Epidemiologic Methods::Data Collection::Interviews as Topic::Focus Groups [Medical Subject Headings]:Analytical Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Epidemiologic Methods::Data Collection::Interviews as Topic [Medical Subject Headings]:Health Care::Health Care Facilities Manpower and Services::Health Personnel::Physicians::Physicians Primary Care [Medical Subject Headings]:Disciplines and Occupations::Natural Science Disciplines::Science::Research::Empirical Research::Qualitative Research [Medical Subject Headings]Mental healthFocus groupPsychotherapyQualitative study:Psychiatry and Psychology::Behavior and Behavior Mechanisms::Behavior::Behavioral Symptoms::Depression [Medical Subject Headings]businessQualitative research
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Theory-based digital intervention to promote weight loss and weight loss maintenance (Choosing Health)

2020

IntroductionDigital behavioural weight loss interventions have the potential to improve public health; however, these interventions are often not adequately tailored to the needs of the participants. This is the protocol for a trial that aims to determine the effectiveness and cost-effectiveness of the Choosing Health programme as a means to promote weight loss and weight loss maintenance among overweight/obese adults.Methods and analysisThe proposed study is a two-group randomised controlled trial with a nested interrupted time series (ITS) within-person design. Participants (n=285) will be randomly assigned to either the Choosing Health digital intervention or a control group. For interve…

N of 1 trialComparative Effectiveness ResearchPsychological interventionOverweightCardiovascularOral and gastrointestinalDISEASElaw.inventionBEHAVIORAL INTERVENTIONSRandomized controlled trialWeight losslaw1506teleterveydenhuoltoRandomized Controlled Trials as TopicNutrition and MetabolismElectronic Mailpublic healthRPRIMARY-CAREGeneral MedicineinterventiotutkimusStrokeN-OF-1OBESITYPublic Health and Health ServicesMedicinemedicine.symptom1714Adultmedicine.medical_specialtyClinical Trials and Supportive ActivitiesClinical Sciencespreventive medicinepainonhallintaDIETQuality of life (healthcare)Clinical ResearchWeight LossmedicineHumansObesityMetabolic and endocrinePreventive healthcareNutritionnutrition & dieteticsOther Medical and Health SciencesOVERWEIGHTbusiness.industryPublic healthPreventionlaihdutusADULTSOverweightPHYSICAL-ACTIVITYCost Effectiveness ResearchterveyskäyttäytyminenPhysical therapyQuality of Life3.1 Primary prevention interventions to modify behaviours or promote wellbeingPolandGeneric health relevancebusinessBMJ Open
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Sākumskolas skolēnu dabaszinātņu sasniegumus ietekmējošie valsts līmeņa faktori starptautiskajos salīdzinošajos pētījumos izglītības vadības skatījumā

2013

Elektroniskā versija nesatur pielikumus

Natural history (Study and teaching)SākumizglītībaEducation PrimaryDabaszinātnes (Mācīšana un mācīšanās)Izglītības vadībaVadība un administrēšana un nekustamo īpašumu pārvaldība
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Norwegian municipal rehabilitation services in transition

2018

Background: Intending to meet increased demands of health care services due to the demographic change with an increasing elderly population, Norwegian municipalities along with many other western countries over the last couple of years have increased responsibility for providing rehabilitation services. The services include integrated homebased rehabilitation and institution- based rehabilitation services. The purpose of this study: How have workforces from the primary healthcare services experienced an increased responsibility for somatic rehabilitation? Methods: The study was based on qualitative research methods. We conducted five focus-group interviews with 25 participants with professi…

Occupational therapyfocus groups; rehabilitation; self-determination; primary healthcare servicesmedicine.medical_specialtyHealth (social science)RehabilitationSociology and Political Sciencebusiness.industryHealth Policymedia_common.quotation_subjectmedicine.medical_treatmentFocus groupNursingMultidisciplinary approachHealth caremedicinebusinessPsychologyCompetence (human resources)AutonomyQualitative researchmedia_commonInternational Journal of Integrated Care (IJIC)
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Seagrass ecosystem response to long-term high CO2 in a Mediterranean volcanic vent

2014

We examined the long-term effect of naturally acidified water on a Cymodocea nodosa meadow growing at a shallow volcanic CO2 vent in Vulcano Island (Italy). Seagrass and adjacent unvegetated habitats growing at a low pH station (pH = 7.65 ± 0.02) were compared with corresponding habitats at a control station (pH = 8.01 ± 0.01). Density and biomass showed a clear decreasing trend at the low pH station and the below- to above-ground biomass ratio was more than 10 times lower compared to the control. C content and delta 13C of leaves and epiphytes were significantly lower at the low pH station. Photosynthetic activity of C. nodosa was stimulated by low pH as seen by the significant increase in…

Ocean Acidification International Coordination Centre (OA-ICC)TemperateSalinityChlorophyll ainorganicAlkalinityLight saturation point standard errorPhotosynthetic quantum efficiencyMediterranean Sea Acidification in a Changing Climate MedSeATemperature waterCarbon inorganic dissolvedCalculated using seacarb after Nisumaa et al 2010IrradianceRespiration rate carbonAragonite saturation stateBiomassAlkalinity totalIrradiance standard errortotalCO2 ventCymodocea nodosapHRespirationEpiphytes loadMaximum photochemical quantum yield of photosystem II standard errorNet community production of carbonTemperaturePartial pressure of carbon dioxide (water) at sea surface temperature (wet air) standard errordissolvedRespiration rate carbon standard errorCarbonate ionMaximum photochemical quantum yield of photosystem IIPartial pressure of carbon dioxide (water) at sea surface temperature (wet air)Net community production of carbon standard errorIlluminance standard errorSoft bottom communitystandard errorCarbon inorganic dissolved standard errorRespiration rateElectron transport rate standard errorEarth System Researchδ13CPhotosynthetic quantum efficiency standard errorField observationChlorophyll a standard errorGross primary production of carbonBiomass standard errorCalcium carbonatePotentiometric titrationCalcite saturation stateShoot densityPotentiometricwaterIlluminanceOxygen standard errorBenthosAlkalinity total standard errorMediterranean Sea Acidification in a Changing Climate (MedSeA)Electron transport rateLight saturation pointOcean Acidification International Coordination Centre OA ICCMediterranean SeaGross primary production of carbon standard errorBicarbonate ionSoft-bottom communityδ13C standard errorTemperature water standard errorCalculated using seacarb after Nisumaa et al. (2010)Primary production PhotosynthesisSpeciespH standard errorCarbonate system computation flagloadPrimary production/PhotosynthesisFugacity of carbon dioxide (water) at sea surface temperature (wet air)CarbonBiomass/Abundance/Elemental compositionTreatmentEpiphytes load standard errorOxygenPartial pressure of carbon dioxide water at sea surface temperature wet airEpiphytes loadCarbon dioxideCarbon standard errorEntire communityFugacity of carbon dioxide water at sea surface temperature wet airGroupBiomass Abundance Elemental compositionCoast and continental shelfEpiphytesShoot density standard errorCalcium carbonate standard error
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Excess risk of subsequent malignant neoplasms in adolescent and young adult cancer survivors: Results from the first Italian population-based cohort

2022

Background: Evidence about late effects in adolescent and young adult (AYA) cancer survivors is scarce. This study assessed the risk of subsequent malignant neoplasms (SMNs) to identify the most common SMNs to be considered in follow-up care. Methods: Population-based cancer registries retrospectively identified first primary tumors (between 1976 and 2013) and SMNs in AYAs (15-39 years old at their cancer diagnosis). AYA cancer survivors were those alive at least 5 years after their first cancer diagnosis. The excess risk of SMNs was measured as standardized incidence ratios (SIRs) and absolute excess risk together with the cumulative incidence of SMNs. Results: The cohort included 67,692 A…

OncologyAdultMaleCancer Researchmedicine.medical_specialtyAdolescentColorectal cancercancer survivorPopulationBreast NeoplasmsSettore MED/42 - Igiene Generale E ApplicataProstate cancerBreast cancerRisk FactorsInternal medicineNeoplasmsfollow-upMedicineHumanscancer survivorsCumulative incidenceadolescentseducationLung cancerRetrospective Studieseducation.field_of_studyBladder cancerbusiness.industryIncidenceCancerregistriesNeoplasms Second Primarymedicine.diseasehumanitiesregistrieOncologyadolescents cancer survivors follow-up registries young adultyoung adultFemalebusiness
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Paclitaxel and carboplatin vs gemcitabine and vinorelbine in patients with adeno- or undifferentiated carcinoma of unknown primary: a randomised pros…

2008

Platinum/taxane combinations are widely used in patients with carcinoma of unknown primary (CUP), yielding response rates of 30% and median overall survival of 9-11 months in selected patients. Yet these combinations have not been subject to a randomised trial to overcome selection bias, a major problem in CUP. We randomised 92 patients to either paclitaxel/carboplatin (arm A) or the non-platinum non-taxane regimen gemcitabine/vinorelbine (arm B). The primary endpoint was rate of practicability as defined: application of >or=2 cycles of therapy (1) with a maximal delay of 1 week (2) and survival of >or=8 months (3). Practicability was shown in 52.4% (95% CI 36-68%) in arm A and in 42.2% (95…

OncologyAdultMaleCancer Researchmedicine.medical_specialtyPaclitaxelmedicine.medical_treatmentneoplasmsVinorelbineVinblastineDeoxycytidineCarboplatinchemistry.chemical_compoundInternal medicineAntineoplastic Combined Chemotherapy ProtocolsClinical StudiesmedicineClinical endpointHumansProspective StudiesAgedProportional Hazards ModelsChemotherapyTaxaneclinical trial phase IIbusiness.industryVinorelbineMiddle AgedGemcitabinemedical oncologyGemcitabineCarboplatinSurgeryErbB ReceptorsRegimenOncologyDocetaxelchemistryrandomized controlled trialunknown primaryNeoplasms Unknown Primaryanti-neoplastic-combined chemotherapy protocolsFemalebusinessmedicine.drugBritish journal of cancer
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The risk of developing a second, different, cancer among 14 560 survivors of malignant cutaneous melanoma: a study by AIRTUM (the Italian Network of …

2008

The aim of this study was to provide further quantitative data on the risk of second nonmelanoma cancers in patients with cutaneous malignant melanoma (CMM). A cohort of 14 560 population-based patients from the Italian Network of Cancer Registries incident during 1985-2002 were included and followed up for further incident cases and vital status. Standardized incidence ratios (SIR) were used to compare the number of observed second cancers with expected cancers. In a total of 69 581 person-years, 1020 second cancers were registered, of which 804.6 were expected (SIR=1.27; 95% confidence interval 1.19-1.35). The risk was similar for males and females, (SIR=1.27 and 1.26, respectively). The …

OncologyAdultMaleCancer Researchmedicine.medical_specialtySkin NeoplasmsSettore MED/06 - Oncologia MedicaPopulationDermatologyCohort StudiesRisk FactorsInternal medicineEpidemiology of cancerMedicineHumansRegistriesSurvivorseducationMelanomaAgedAged 80 and overeducation.field_of_studybusiness.industryIncidence (epidemiology)CancerNeoplasms Second PrimaryMiddle Agedmedicine.diseasehumanitiesConfidence intervalcutaneous melanomacancerOncologyItalyCohortCutaneous melanomaFemalesecond cancer - survivors - malignant melanomabusinessCohort studyFollow-Up StudiesMelanoma research
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