Search results for " REPOSI"

Contextual Metadata for Document Databases

2005

Metadata has always been an important means to support accessibility of information in document collections. Metadata can be, for example, bibliographic data manually created for each document at the time of document storage. The indexes created by Web search engines serve as metadata about the content of Web documents. In the semantic Web solutions, ontologies are used to store semantic metadata (Berners-Lee et al., 2001). Attaching a common ontology to a set of heterogeneous document databases may be used to support data integration. Creation of the common ontology requires profound understanding of the concepts used in the databases. It is a demanding task, especially in cases where the …

Open educational resources repositories literature review – Towards a comprehensive quality approaches framework

2015

Display Omitted A comprehensive literature review on learning object repositories (LOR) quality approaches.Most cited quality approaches are "peer reviews" and "recommendation systems".User-generated, collaborative, quality instruments are favored for their sustainability.Main result is a Quality approach framework for LOR design. Today, Open Educational Resources (OER) are commonly stored, used, adapted, remixed and shared within Learning object repositories (LORs) which have recently started expanding their design to support collaborative teaching and learning. As numbers of OER available freely keep on growing, many LORs struggle to find sustainable business models and get the users' att…

Physico-chemical evolution of low-pH cements : influence of the temperature and the retention mechanisme of alkalins

2010

Because of their high alkalinity, Portland cement (OPC)-based materials may have deleterious effects in an underground waste repository. A solution would be to use low-alkalinity cements (also referred as low-pH cements) generating interstitial solutions with a reduced pH (11 instead of 13.5 for OPC), and thus showing an improved chemical compatibility with the repository environment. In this work, the investigated formulations were based on binary (OPC / silica fume) or ternary (OPC / silica fume / slag or fly ash) blends, with high substitution levels of CEM I (from 30% to 80%). This research project met two main objectives: (i) study the chemical evolution of low-pH cements at 50°C or 80…

Adherence to a Mediterranean diet is associated with lower incidence of frailty: A longitudinal cohort study

2018

Background & aims There is a paucity of data investigating the relationship between the Mediterranean diet and frailty, with no data among North American people. We aimed to investigate if adherence to a Mediterranean diet is associated with a lower incidence of frailty in a large cohort of North American people. Methods This study included subjects at higher risk or having knee osteoarthritis. Adherence to the Mediterranean diet was evaluated using a validated Mediterranean diet score (aMED) as proposed by Panagiotakos and classified into five categories. Frailty was defined using the Study of Osteoporotic Fracture (SOF) index as the presence of ≥2 out of: (i) weight loss ≥5% between b…

In-hospital death and adverse clinical events in elderly patients according to disease clustering: The REPOSI study

2010

OBJECTIVE: The aim of the study was to recognize clusters of diseases among hospitalized elderly and to identify groups of patients at risk of in-hospital death and adverse clinical events according to disease clustering. METHOD: This was a cross-sectional study conducted in 38 internal medicine and geriatric wards in Italy participating in the Registro Politerapie SIMI (REPOSI) study during 2008. The subjects were 1,332 inpatients aged 65 years or older. Clusters of diseases (i.e., two or more co-occurrent diseases) were identified using the odds ratios (OR) for the associations between pairs of conditions, followed by cluster analysis. Logistic regression models were used to evaluate the …

Computer-guided drug repurposing: Identification of trypanocidal activity of clofazimine, benidipine and saquinavir

2015

In spite of remarkable advances in the knowledge on Trypanosoma cruzi biology, no medications to treat Chagas disease have been approved in the last 40 years and almost 8 million people remain infected. Since the public sector and non-profit organizations play a significant role in the research efforts on Chagas disease, it is important to implement research strategies that promote translation of basic research into the clinical practice. Recent international public-private initiatives address the potential of drug repositioning (i.e. finding second or further medical uses for known-medications) which can substantially improve the success at clinical trials and the innovation in the pharmac…

Clinical Severity, Age, and Sex Overcome Cardiometabolic Morbidities but Not Stroke as Predictors of Mortality in Elderly Inpatients: Data From the R…

2016

Predictors of clinical events occurring during hospital stay among elderly patients admitted to medical wards in Italy.

2016

Abstract Background Clinical events occurring during hospital stay are independent predictors of prolonged hospitalization, in-hospital mortality and readmission among elderly patients admitted to medical wards. Purpose To identify predictors of intercurrent clinical events (ICE) during hospital stay among the main demographic, functional and clinical characteristics assessed at hospital admission in a multicenter sample of elderly inpatients in Italy. Methods This observational prospective cohort study was conducted in 66 internal and geriatric medicine hospital wards in 2010. It enrolled 1267 inpatients aged 65 years or older living at home before hospitalization. Multivariable Poisson re…

Brain and kidney, victims of atrial microembolism in elderly hospitalized patients? Data from the REPOSI study

2015

Abstract Background It is well known that atrial fibrillation (AF) and chronic kidney disease (CKD) are associated with a higher risk of stroke, and new evidence links AF to cognitive impairment, independently from an overt stroke (CI). Our aim was to investigate, assuming an underlying role of atrial microembolism, the impact of CI and CKD in elderly hospitalized patients with AF. Methods We retrospectively analyzed the data collected on elderly patients in 66 Italian hospitals, in the frame of the REPOSI project. We analyzed the clinical characteristics of patients with AF and different degrees of CI. Multivariate logistic analysis was used to explore the relationship between variables an…

One Phase Commit: A Low Overhead Atomic Commitment Protocol for Scalable Metadata Services

2012

As the number of client machines in high end computing clusters increases, the file system cannot keep up with the resulting volume of requests, using a centralized metadata server. This problem will be even more prominent with the advent of the exascale computing age. In this context, the centralized metadata server represents a bottleneck for the scaling of the file system performance as well as a single point of failure. To overcome this problem, file systems are evolving from centralized metadata services to distributed metadata services. The metadata distribution raises a number of additional problems that must be taken into account. In this paper we will focus on the problem of managi…