Search results for " RISK FACTORS"

showing 10 items of 570 documents

Blood cell transcript levels in 5-year-old children as potential markers of breastfeeding effects in those small for gestational age at birth

2019

BackgroundNutrition of the newborn during the early postnatal period seems to be of capital importance and there is clinical evidence showing the protective effect of breastfeeding compared with formula feeding on childhood obesity and its comorbidities. Infants born small for gestation age may be more sensitive to the type of feeding during lactation. Here, we aimed to analyze the impact of birth weight and the type of infant feeding on the expression levels in peripheral blood cells of selected candidate genes involved in energy homeostasis in 5-year-old children, to find out potential early biomarkers of metabolic programming effects during this period of metabolic plasticity.MethodsFort…

Male0301 basic medicinehumanosBreastfeedingPhysiologylcsh:MedicineSangBlood Pressureregulación de la expresión génicalactancia materna0302 clinical medicineLactationBirth Weightcélulas sanguíneasGeneral MedicineARNmedicine.anatomical_structureBreast FeedingChild Preschool030220 oncology & carcinogenesisInfant Small for Gestational AgeInfant formulaGestationFemaleInfantspresión sanguíneaBreast milkSystoleBirth weightBreast milkGeneral Biochemistry Genetics and Molecular BiologyChildhood obesity03 medical and health sciencessístoleMetabolic programmingmedicineHumansRNA Messengerpeso al nacerlactanteBlood Cellsbusiness.industryResearchlcsh:RInfant NewbornInfantmedicine.diseaseCardiometabolic risk factors030104 developmental biologyInfant formulaGene Expression RegulationSmall for gestational ageRNAbusinessBiomarkers
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Relapse risk factors in anti-N-methyl-D-aspartate receptor encephalitis

2019

Aim: To identify factors that may predict and affect the risk of relapse in anti-N-methyl-D-aspartate receptor (NMDAR) encephalitis. Method: This was a retrospective study of an Italian cohort of patients with paediatric (≤18y) onset anti-NMDAR encephalitis. Results: Of the 62 children included (39 females; median age at onset 9y 10mo, range 1y 2mo–18y; onset between 2005 and 2018), 21 per cent relapsed (median two total events per relapsing patient, range 2–4). Time to first relapse was median 31.5 months (range 7–89mo). Severity at first relapse was lower than onset (median modified Rankin Scale [mRS] 3, range 2–4, vs median mRS 5, range 3–5; admission to intensive care unit: 0/10 vs 3/10…

Male030506 rehabilitationGastroenterologyCohort Studies0302 clinical medicineRetrospective StudieModified Rankin ScaleRecurrenceRisk FactorsChildrelapseAnti-N-Methyl-D-Aspartate Receptor EncephalitisHazard ratioItalyChild PreschoolCohortanti‐N‐methyl‐D‐aspartate receptor encephalitisFemale0305 other medical scienceEncephalitisHumanCohort studymedicine.medical_specialtyAdolescentSocio-culturaleanti-NMDAR antibodies03 medical and health sciencesanti-NMDARDevelopmental NeuroscienceInternal medicinemedicineAdolescent; Anti-N-Methyl-D-Aspartate Receptor Encephalitis; Child; Child Preschool; Cohort Studies; Female; Humans; Infant; Italy; Male; Recurrence; Retrospective Studies; Risk FactorsHumansPreschoolSurvival analysisRetrospective StudiesAutoimmune encephalitisbusiness.industryInfantRetrospective cohort studymedicine.diseaseanti-NMDAR antibodies autoimmune encephalitis anti‐N‐methyl‐D‐aspartate receptor encephalitisautoimmune encephalitisAnti-N-methyl-D-aspartate receptor encephalitis anti-NMDAR autoimmune encephalitis relapseAnti-N-Methyl-D-Aspartate Receptor EncephalitiPediatrics Perinatology and Child HealthNeurology (clinical)Cohort Studiebusiness030217 neurology & neurosurgery
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Gait asymmetry, ankle spasticity, and depression as independent predictors of falls in ambulatory stroke patients

2017

Background Falls are the leading cause of injury in stroke patients. However, the cause of a fall is complicated, and several types of risk factors are involved. Therefore, a comprehensive model to predict falls with high sensitivity and specificity is needed. Methods This study was a prospective study of 112 inpatients in a rehabilitation ward with follow-up interviews in patients’ homes. Evaluations were performed 1 month after stroke and included the following factors: (1) status of cognition, depression, fear of fall and limb spasticity; (2) functional assessments [walking velocity and the Functional Independence Measure (FIM)]; and (3) objective, computerized gait and balance analyses.…

Male030506 rehabilitationPhysiologylcsh:MedicinePoison controlWalkingVascular MedicineGeriatric DepressionCognitionMathematical and Statistical Techniques0302 clinical medicineRisk FactorsMedicine and Health SciencesMedicinePublic and Occupational HealthProspective Studieslcsh:ScienceGaitPostural BalanceStrokeAged 80 and overMultidisciplinaryDepressionTraumatic Injury Risk FactorsStroke RehabilitationFearMiddle AgedPrognosisFunctional Independence MeasureBiomechanical PhenomenaStrokeNeurologyMuscle SpasticityPhysical SciencesFemaleFallsmedicine.symptomGait Analysis0305 other medical scienceStatistics (Mathematics)Research Articlemedicine.medical_specialtyCerebrovascular DiseasesGeriatric PsychiatryResearch and Analysis Methods03 medical and health sciencesPhysical medicine and rehabilitationGait trainingMental Health and PsychiatryHumansSpasticityStatistical MethodsAgedBalance (ability)Balance and FallsBiological LocomotionMood Disordersbusiness.industrylcsh:RBiology and Life Sciencesmedicine.diseaseGaitGeriatricsGait analysisPhysical therapylcsh:QAccidental FallsAnklebusinessMathematics030217 neurology & neurosurgeryFollow-Up StudiesForecastingPLOS ONE
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Is physician assessment of alcohol consumption useful in predicting risk of severe liver disease among people with HIV and HIV/HCV co-infection?

2019

AbstractBackgroundAlcohol consumption is a known risk factor for liver disease in HIV-infected populations. Therefore, knowledge of alcohol consumption behaviour and risk of disease progression associated with hazardous drinking are important in the overall management of HIV disease. We aimed at assessing the usefulness of routine data collected on alcohol consumption in predicting risk of severe liver disease (SLD) among people living with HIV (PLWHIV) with or without hepatitis C infection seen for routine clinical care in Italy.MethodsWe included PLWHIV from two observational cohorts in Italy (ICONA and HepaICONA). Alcohol consumption was assessed by physician interview and categorized ac…

Male030508 substance abuseHIV InfectionsSeverity of Illness IndexCohort StudiesLiver disease0302 clinical medicineRisk FactorsEpidemiologyMedicineHIV InfectionAlcohol consumptionAlcohol consumption HIV-infected HIV/HCV co-infection Severe liver disease030212 general & internal medicineeducation.field_of_studyCoinfectionLiver Diseaselcsh:Public aspects of medicineLiver DiseasesHazard ratioHepatitis CMiddle AgedHepatitis CItalyalcohol consumption; HIV-infected; HIV/HCV co-infection; severe liver diseaseCoinfectionFemale0305 other medical scienceHumanCohort studyResearch ArticleAdultmedicine.medical_specialtyAlcohol DrinkingPopulationSevere liver diseaseHIV/HCV co-infectionNO03 medical and health sciencesEnvironmental healthHumansRisk factorAlcohol consumption; HIV-infected; HIV/HCV co-infection; Severe liver disease; Adult; Alcohol Drinking; Cohort Studies; Female; HIV Infections; Hepatitis C; Humans; Italy; Liver Diseases; Male; Middle Aged; Risk Factors; Severity of Illness Index; CoinfectioneducationHIV-infectedbusiness.industryRisk FactorPublic Health Environmental and Occupational Healthlcsh:RA1-1270medicine.diseaseCohort StudiebusinessBMC Public Health
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Treated Incidence of Psychotic Disorders in the Multinational EU-GEI Study

2018

Importance: Psychotic disorders contribute significantly to the global disease burden, yet the latest international incidence study of psychotic disorders was conducted in the 1980s. Objectives: To estimate the incidence of psychotic disorders using comparable methods across 17 catchment areas in 6 countries and to examine the variance between catchment areas by putative environmental risk factors. Design, Setting, and Participants: An international multisite incidence study (the European Network of National Schizophrenia Networks Studying Gene-Environment Interactions) was conducted from May 1, 2010, to April 1, 2015, among 2774 individuals from England (2 catchment areas), France (3 catch…

Male2.3 Psychological social and economic factorsSYMPTOMS[SDV.NEU.NB]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC]/Neurobiologyenvironmental risk factorsCatchment Area HealthRisk FactorsSCHIZOPHRENIADEPRIVATIONComputingMilieux_MISCELLANEOUShealth care economics and organizationsMinority Groups44 Human SocietyOriginal InvestigationNetherlands2 AetiologyOUTCOMES[SDV.NEU.PC]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC]/Psychology and behaviorpsychotic disorders; international multisite incidence study; EU-GEI Study; environmental risk factorsIncidenceAge Factors[SDV.NEU.SC]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC]/Cognitive SciencesMental HealthEnglandItalyPsychiatry and Mental Health4206 Public Healthpopulation characteristicsFemaleFrancegeographic locationsBrazilAdultCross-Cultural ComparisonURBANICITYeducationAGESex Factorsparasitic diseasesHumans1ST-EPISODE PSYCHOSISRATESNOTTINGHAMinternational multisite incidence studyMETAANALYSISPublishingEU-GEI Study[SCCO.NEUR]Cognitive science/NeurosciencePrevention42 Health SciencesPsychotic DisordersSpainGene-Environment Interaction
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Physiological parameters for Prognosis in Abdominal Sepsis (PIPAS) Study: a WSES observational study

2019

Timing and adequacy of peritoneal source control are the most important pillars in the management of patients with acute peritonitis. Therefore, early prognostic evaluation of acute peritonitis is paramount to assess the severity and establish a prompt and appropriate treatment. The objectives of this study were to identify clinical and laboratory predictors for in-hospital mortality in patients with acute peritonitis and to develop a warning score system, based on easily recognizable and assessable variables, globally accepted. Background Timing and adequacy of peritoneal source control are the most important pillars in the management of patients with acute peritonitis. Therefore, early pr…

Male:Medicina Básica [Ciências Médicas]030230 surgeryLogistic regression0302 clinical medicineInjury Severity ScoreInterquartile rangeRisk FactorsAntibioticsAbdomenDiagnosisAcute peritonitis; Early warning score; Emergency surgery; Source control; Abdomen; Adult; Aged; Chi-Square Distribution; Female; Hospital Mortality; Humans; Injury Severity Score; Logistic Models; Male; Middle Aged; Risk Factors; Sepsis; PrognosisHospital MortalityMortality rateAcute peritonitilcsh:Medical emergencies. Critical care. Intensive care. First aidaarly warning scoreAcute peritonitisMiddle AgedEarly warning scorePrognosisacute peritonitis; aarly warning score; emergency surgery; source control; abdomen; adult; aged; chi-square distribution; female; hospital mortality; humans; injury severity score; logistic models; male; middle aged; risk factors; sepsis; prognosis3. Good healthManagementCiências Médicas::Medicina BásicaEmergency MedicineEmergency surgeryInjury Severity ScoreFemaleResearch ArticleHumanAdultmedicine.medical_specialtyLogistic ModelSepsilcsh:SurgeryNO03 medical and health sciencesSource controlInternal medicineSepsismedicineHumansAgedAcute appendicitisScience & TechnologyChi-Square Distributionbusiness.industryAcute peritonitis; Early warning score; Emergency surgery; Source controlRisk FactorAcute appendicitis; Antibiotics; Diagnosis; Management; SurgeryEarly warning scorelcsh:RD1-811lcsh:RC86-88.93126 Surgery anesthesiology intensive care radiologymedicine.diseaseAcute peritonitis ; Early warning score ; Emergency surgery ; Source controlLogistic ModelsObservational studySurgerybusinessChi-squared distributionKidney disease
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Geo-economic variations in epidemiology, patterns of care, and outcomes in patients with acute respiratory distress syndrome: insights from the LUNG …

2017

Background Little information is available about the geo-economic variations in demographics, management, and outcomes of patients with acute respiratory distress syndrome (ARDS). We aimed to characterise the effect of these geo-economic variations in patients enrolled in the Large Observational Study to Understand the Global Impact of Severe Acute Respiratory Failure (LUNG SAFE). Methods LUNG SAFE was done during 4 consecutive weeks in winter, 2014, in a convenience sample of 459 intensive-care units in 50 countries across six continents. Inclusion criteria were admission to a participating intensive-care unit (including transfers) within the enrolment window and receipt of invasive or non…

MaleARDSdemographyeconomicmedicine.medical_treatmentTerapéuticaair conditioningComorbidityintensive care unitdeveloped country0302 clinical medicineneuromuscular blockingmiddle agedacute myocardial-infarctionmiddle income countryProspective StudiesGeography Medicalcritically-ill patientsadultagedpriority journalrisk factorIncomegeographic-variationDeveloped countryhospitalizationprospective studyHumanPulmonary and Respiratory MedicineDeveloped Countriemedicine.medical_specialtyDeveloping countryArticle/dk/atira/pure/subjectarea/asjc/2700/274003 medical and health sciencesSíndrome respiratorio agudo graveunitsMedicalHumansIntensive care medicineDeveloping CountriesAgedhigh income countryRespiratory Distress Syndrome Adultnoninvasive ventilationAparato respiratoriomedicine.diseasemortalitymajor clinical studyProspective Studiearterial oxygen tension030228 respiratory systemARDSObservational studySociologíahealth care deliverygeographyintensive-careRisk FactorsEpidemiologyProspective cohort studyRespiratory Distress Syndromepartial pressureartificial ventilationSociología médicaMiddle Agedadult respiratory distress syndromeAged; Comorbidity; Delivery of Health Care; Developed Countries; Developing Countries; Europe; Female; Geography Medical; Humans; Income; Intensive Care Units; Male; Middle Aged; Patient Outcome Assessment; Prospective Studies; Respiratory Distress Syndrome Adult; Risk Factors; Pulmonary and Respiratory MedicineEuropeIntensive Care UnitsfemaleincomeFemaleEnfermedadinjurycohort analysigross national incomesurvivalNOmedical geographyDeveloping Countrielength of staymedicinecontrolled studyoutcome assessmentbreast-cancerMechanical ventilationdiseasebusiness.industryDeveloped Countriespatient caredeveloping country030208 emergency & critical care medicinestatistics and numerical data AgedComorbiditywinterACUTE MYOCARDIAL-INFARCTION; CRITICALLY-ILL PATIENTS; GEOGRAPHIC-VARIATION; INTENSIVE-CARE; BREAST-CANCER; MORTALITY; DISEASE; INJURY; UNITS; HOSPITALIZATIONPatient Outcome AssessmentEmergency medicineprone positiontreatment outcomebusinessDelivery of Health Care
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Immunocompromised patients with acute respiratory distress syndrome: Secondary analysis of the LUNG SAFE database

2018

Background: The aim of this study was to describe data on epidemiology, ventilatory management, and outcome of acute respiratory distress syndrome (ARDS) in immunocompromised patients. Methods: We performed a post hoc analysis on the cohort of immunocompromised patients enrolled in the Large Observational Study to Understand the Global Impact of Severe Acute Respiratory Failure (LUNG SAFE) study. The LUNG SAFE study was an international, prospective study including hypoxemic patients in 459 ICUs from 50 countries across 5 continents. Results: Of 2813 patients with ARDS, 584 (20.8%) were immunocompromised, 38.9% of whom had an unspecified cause. Pneumonia, nonpulmonary sepsis, and noncardiog…

MaleARDSmodelos logísticosDatabases Factualmedicine.medical_treatment[SDV]Life Sciences [q-bio]humanoslnfectious Diseases and Global Health Radboud Institute for Molecular Life Sciences [Radboudumc 4]Kaplan-Meier EstimateCritical Care and Intensive Care MedicineAcute respiratory failureSeverity of Illness IndexCohort Studiesrandomized-trial0302 clinical medicineMechanical ventilationRisk Factorsestudios prospectivosEpidemiology80 and overicuMedicineProspective StudiesProspective cohort studyestudios de cohortesImmunodeficiencymediana edadestadísticasAged 80 and overRespiratory Distress Syndromeancianocritically-ill patientsRespirationresultado del tratamientorespiraciónStatisticslcsh:Medical emergencies. Critical care. Intensive care. First aidadultoMiddle Aged3. Good healthfailureIntensive Care UnitsTreatment OutcomeArtificialCohortprospective multicenterImmunocompromised patientsAcute respiratory failure; ARDS; Immunocompromised patients; Mechanical ventilation; Noninvasive ventilation; Critical Care and Intensive Care MedicineFemaleNoninvasive ventilationHumanestimación de Kaplan-MeierAdultmedicine.medical_specialtyLogistic ModelIntensive Care UnitSocio-culturaleunidades de cuidados intensivossurvivalStatistics NonparametricSepsisDatabases03 medical and health sciencesImmunocompromised HostInternal medicineImmunocompromised patientcancerfactores de riesgoHumansNonparametricíndice de gravedad de la enfermedadintensive-care-unitFactualAgedMechanical ventilationbusiness.industryResearchRisk FactorRespiratory Distress Syndrome Adult030208 emergency & critical care medicinelcsh:RC86-88.9medicine.diseaseRespiration ArtificialPneumoniaProspective StudieLogistic Models030228 respiratory systemmalignanciesARDShuésped inmunodeprimidoCohort StudiebusinessAcute respiratory failure; ARDS; Immunocompromised patients; Mechanical ventilation; Noninvasive ventilation; Adult; Aged; Aged 80 and over; Cohort Studies; Databases Factual; Female; Humans; Intensive Care Units; Kaplan-Meier Estimate; Logistic Models; Male; Middle Aged; Prospective Studies; Respiration Artificial; Respiratory Distress Syndrome Adult; Risk Factors; Severity of Illness Index; Statistics Nonparametric; Treatment Outcome; Immunocompromised Host
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Risk Factors for Intracerebral Hemorrhage in Patients With Atrial Fibrillation on Non–Vitamin K Antagonist Oral Anticoagulants for Stroke Prevention

2021

Background and Purpose: Clinical trials on stroke prevention in patients with atrial fibrillation have consistently shown clinical benefit from either warfarin or non–vitamin K antagonist oral anticoagulants (NOACs). NOAC-treated patients have consistently reported to be at lower risk for intracerebral hemorrhage (ICH) than warfarin-treated patients. The aims of this prospective, multicenter, multinational, unmatched, case-control study were (1) to investigate for risk factors that could predict ICH occurring in patients with atrial fibrillation during NOAC treatment and (2) to evaluate the role of CHA 2 DS 2 -VASc and HAS-BLED scores in the same setting. Methods: Cases were consecutive pa…

MaleAdministration Oral030204 cardiovascular system & hematologySettore MED/110302 clinical medicine80 and overrisk factorsMedicineatrial fibrillationProspective StudiesAged 80 and overatrial fibrillation; cerebral hemorrhage; logistic models; risk factors; white matter; Administration Oral; Aged; Aged 80 and over; Antithrombins; Atrial Fibrillation; Case-Control Studies; Cerebral Hemorrhage; Female; Humans; Male; Middle Aged; Prospective Studies; Risk Factors; StrokeAtrial fibrillationMiddle AgedVitamin K antagonist3. Good healthStrokeAdministrationSettore MED/26 - NeurologiaFemaleCardiology and Cardiovascular Medicinewhite mattermedicine.drugOralmedicine.medical_specialtymedicine.drug_classSettore MED/26Lower riskAntithrombins03 medical and health sciencesInternal medicineHumanscardiovascular diseaseslogistic modelAgedAdvanced and Specialized NursingIntracerebral hemorrhagecerebral hemorrhagebusiness.industryWarfarinmedicine.diseaseClinical trialatrial fibrillation; cerebral hemorrhage; logistic models; risk factors; white matterCase-Control StudiesConcomitantHeart failureNeurology (clinical)businesslogistic models030217 neurology & neurosurgeryStroke
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Coronary artery calcium and physical performance as determinants of mortality in older age: The AGES-Reykjavik Study

2013

Background. Coronary artery calcium (CAC) and physical performance have been shown to be associated with mortality, but it is not clear whether one of them modifies the association. We investigated the association between the extent of CAC and physical performance among older individuals and explored these individual and combined effects on cardiovascular disease (CVD) mortality and non-CVD mortality. Methods. We studied 4074 participants of the AGES–Reykjavik Study who were free from coronary heart disease, had a CAC score calculated from computed tomography scans and had data on mobility limitations and gait speed at baseline in 2002–2006 at a mean age of 76 years. Register-based mortalit…

MaleAgingcardiovascular disease risk factorsEpidemiologyIcelandikääntyneet henkilötDiseaseCoronary Artery DiseaseCoronary artery calcificationCardiovascular disease risk factorsCoronary AngiographySeverity of Illness IndexCoronary artery diseaseRisk FactorsEpidemiologyProspective StudiesepidemiologiaProspective cohort studyAge FactorsCalcinosista3141Coronary VesselsSurvival RateCoronary artery calciumCardiologyfyysinen suorituskykyFemaleCardiology and Cardiovascular Medicinekuolleisuusmedicine.medical_specialtyateroskleroosisepelvaltimoiden kalkkeumaMotor ActivityArticleInternal medicineSeverity of illnessMultidetector Computed TomographymedicineHumanscardiovascular diseasesMortalitySurvival rateAgedbusiness.industryagingnutritional and metabolic diseasesmedicine.diseaseAtherosclerosisGaitcoronary artery calcificationSurgeryCalciumbusinessTomography X-Ray ComputedFollow-Up StudiesInternational Journal of Cardiology
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