Search results for " ROS."
showing 10 items of 424 documents
Pathophysiological role of oxidative stress in systolic and diastolic heart failure and its therapeutic implications
2015
Abstract Systolic and diastolic myocardial dysfunction has been demonstrated to be associated with an activation of the circulating and local renin–angiotensin–aldosterone system (RAAS), and with a subsequent inappropriately increased production of reactive oxygen species (ROS). While, at low concentrations, ROS modulate important physiological functions through changes in cellular signalling and gene expression, overproduction of ROS may adversely alter cardiac mechanics, leading to further worsening of systolic and diastolic function. In addition, vascular endothelial dysfunction due to uncoupling of the nitric oxide synthase, activation of vascular and phagocytic membrane oxidases or mit…
La modernità del sacro. Il matrimonio di Lorna di Pierre e Jean-Pierre Dardenne
2010
Il saggio definisce il concetto di modernità cinematografica alla luce dell'opera dei fratelli Dardenne
Pythium terrestris, a new species isolated from France, its ITS region, taxonomy and its comparison with related species
2002
Pythium terrestris (F-78) was isolated from soil samples taken in Lille in northern France. Its morphology resembles that of Pythium rostratum, and Pythium longandrum, a recently described species. However the antheridial and sporangial characteristics of this new species are unique. The fungus does not sporulate, the sporangium germinates directly into mycelium through germ tubes. The oogonia of P. terrestris are normally provided with hypogynous and monoclinous antheridia, at times the monoclinous antheridial branches wrap around the oogonia forming a complicated knot. Morphological features of this new species, together with the sequences of the internal transcribed spacer (ITS) region o…
Efficacy and safety of adding alirocumab to rosuvastatin versus adding ezetimibe or doubling the rosuvastatin dose in high cardiovascular-risk patien…
2015
OBJECTIVE: To compare lipid-lowering efficacy of adding alirocumab to rosuvastatin versus other treatment strategies (NCT01730053).METHODS: Patients receiving baseline rosuvastatin regimens (10 or 20 mg) were randomized to: add-on alirocumab 75 mg every-2-weeks (Q2W) (1-mL subcutaneous injection via pre-filled pen); add-on ezetimibe 10 mg/day; or double-dose rosuvastatin. Patients had cardiovascular disease (CVD) and low-density lipoprotein cholesterol (LDL-C) ≥70 mg/dL (1.8 mmol/L) or CVD risk factors and LDL-C ≥100 mg/dL (2.6 mmol/L). In the alirocumab group, dose was blindly increased at Week 12 to 150 mg Q2W (also 1-mL volume) in patients not achieving their LDL-C target. Primary endpoi…
Wild Sicilian Rosemary: Phytochemical and Morphological Screening and Antioxidant Activity Evaluation of Extracts and Essential Oils
2015
To identify the best biotypes, an extensive survey of Sicilian wild rosemary was carried out by collecting 57 samples from various sites, followed by taxonomic characterization from an agronomic perspective. All the biotypes collected were classified as Rosmarinus officinalis L. A cluster analysis based on the morphological characteristics of the plants allowed the division of the biotypes into seven main groups, although the characteristics examined were found to be highly similar and not area-dependent. Moreover, all samples were analyzed for their phytochemical content, applying an extraction protocol to obtain the nonvolatile components and hydrodistillation to collect the essential oil…
Sublimare le emozioni: il sacro Monte della devozione (Palermo, secc. XVII-XX)
2021
Il caso di studio presentato è incentrato su Monte Pellegrino, luogo sacro dall’antichità, dove furono rinvenute le reliquie attribuite a S. Rosalia, mentre la città era flagellata dalla peste (1624). Il saggio intende evidenziare come emozioni individuali e collettive abbiano inciso sui processi decisionali e contribuito alla riconfigurazione degli spazi di riferimento. The case study presented focuses on Monte Pellegrino, a sacred place since ancient times, where the relics attributed to St. Rosalia were found, while the city was plagued by the plague (1624). The essay intends to highlight how individual and collective emotions have affected decision-making processes and contributed to th…
Zvaigžņotā Debess: 2008, Pavasaris
2008
Latvijas Zinātņu akadēmija, Latvijas Universitāte
Entrevista a Teresa Ruiz Rosas
2018
es la entrevista a una de las mas renomadas escritoras peruanas contemporaneas: Teresa Ruiz Rosas
Sociālo mediju komunikācija kā integrētās marketinga komunikācijas daļa/elements. “Lauma Lingerie” un “Rosme” gadījumu analīze
2022
Darba tēma – sociālo mediju komunikācija kā integrētās mārketinga komunikācijas daļa/elements. “Lauma Lingerie” un “Rosme” gadījuma analīze. Darba mērķis – izpētīt un analizēt uzņēmumu “Lauma Lingerie” un “New Rosme” komunikāciju sociālajos medijos, noskaidrot, kā sociālo mediju komunikācija tiek izmantota patērētāju informēšanai un kā šo komunikāciju vērtē abu uzņēmumu patērētāji. Teorētiskās pieejas ietvaros ir izmantoti tādu pētnieku kā V. Praude un Šalkovska J.,, Rakic B. un Rakic M., Matetlwa E.N., Reisas R. un citu autoru pētījumi un publikācijas. Pētījuma metodoloģijas pamatā ir izmantotas divas pētījumu metodes. Pirmā pētījumu metode ir aptauja, kura pētījuma gaitā tika pielietota, …
Development of a nanostructured sensor for monitoring oxidative stress in living cells
2018
Oxidative burden is elevated in the lung of COPD patients and is associated with aging and chronic inflammation. When overcoming physiological levels, reactive oxygen species (ROS) cause cell damage and sustain inflammation. Both lung epithelium and alveolar macrophages contribute to ROS generation. Currently, ROS generation is measured using fluorescent probes and colorimetric/fluorimetric assays. We present an amperometric nanostructured sensor for real-time detection of hydrogen peroxide (H2O2) released by living cells. The H2O2 sensing performance was evaluated through the current vs time response of platinum rod at a working potential of −0.45 V vs saturated calomel electrode acting as…