Search results for " Regional"
showing 10 items of 1256 documents
Analyzing Cascading Effects in Interdependent Critical Infrastructures
2018
International audience; Critical Infrastructures (CIs) are resources that are essential for the performance of society, including its economy and its security. Large-scale disasters, whether natural or man-made, can have devastating primary (direct) effects on some CI and significant indirect effects (cascading effects) on other CIs, because CIs are interconnected and depend on each other’s services. Recent work by Laugé et al. expressed the dependency values among CIs as dependency matrices for various durations of the primary CI failure. For better preparedness and mitigation of CI failures knowledge of the weak points in CI interdependencies is crucial. To this effect, we have developed …
The politics of Argentina today: human rights and Kirchnerismo
2016
After the effects of bloody dictatorship that whipped the region, Argentina as many other Latin American countries experienced a great trauma which not only altered the ways politics was lived, but also undermined the social trust of citizens respecting to their institutions. The rise of Kirchneristes and Kirchnerismo post stock and market crisis of 2001, initiated a new age in Argentina. Kirchnerismo opened the doors for the vindication of many claims of human rights organisations, but at the same time, the discourse of human rights was adjusted to the interests of Cristina Kirchner and her followers. As a result of this, the cause of human rights allowed government to produce a new way of…
A common SNP in the UNG gene decreases ovarian cancer risk in BRCA2 mutation carriers
2018
Single nucleotide polymorphisms (SNPs) in DNA glycosylase genes involved in the base excision repair (BER) pathway can modify breast and ovarian cancer risk in BRCA1 and BRCA2 mutation carriers. We previously found that SNP rs34259 in the uracil-DNA glycosylase gene (UNG) might decrease ovarian cancer risk in BRCA2 mutation carriers. In the present study, we validated this finding in a larger series of familial breast and ovarian cancer patients to gain insights into how this UNG variant exerts its protective effect. We found that rs34259 is associated with significant UNG downregulation and with lower levels of DNA damage at telomeres. In addition, we found that this SNP is associated with…
Measles in Italy: Viral strains and crossing borders
2019
In 2017, Italy experienced one of the largest outbreaks of measles in recent years, with 5404 notified cases and 4347 confirmed cases. A further 2029 cases were notified during the first 6 months of 2018, and 1516 of them were laboratory-confirmed. The B3 and D8 genotypes were identified as those responsible for the outbreak. Possible transmission routes can be established by monitoring the circulating measles virus strains in support of the national health authorities to warn people and travellers. Keywords: Outbreak, Measles, Genotype identification, Surveillance
Simultaneous Boron Ion‐Channel/Growth Factor Receptor Activation for Enhanced Vascularization
2018
[EN] Boron ion is essential in metabolism and its concentration is regulated by ion-channel NaBC1. NaBC1 mutations cause corneal dystrophies such as Harboyan syndrome. Here we propose a 3D molecular model for NaBC1 and show that simultaneous stimulation of NaBC1 and vascular growth factor receptors (VEGFR) promote angiogenesis in vitro and in vivo with ultra-low concentrations of VEGF. We show Human Umbilical Vein Endothelial Cells (HUVEC) organization into tubular structures indicative of vascularization potential. Enhanced cell sprouting was found only in the presence of VEGF and boron, effect abrogated after blocking NaBC1. We demonstrate that stimulated NaBC1 promotes angiogenesis via P…
Seafood Consumption, Omega-3 Fatty Acids Intake, and Life-Time Prevalence of Depression in the PREDIMED-Plus Trial.
2018
Background: The aim of this analysis was to ascertain the type of relationship between fish and seafood consumption, omega-3 polyunsaturated fatty acids (&omega
Inner Archipelagos in Sicily. From Culture-Based Development to Creativity-Oriented Evolution
2020
When Covid-19 arrived in Europe from the far East, the media and experts in economics and social sciences noticed that it was the expected discontinuity in the socio-economic development process. Really, the current phase has spread since the 1960s, when the application of econometric worldwide-spread development model was going to produce social inequalities, and consumption of physical, social, and cultural resources. Some places in Italy, far from the erosive and urban context and erosive metropolitan areas, are currently isolated seeds of a new cycle of life, because of the local community identity and the strong link between human, cultural, and natural components are currently working…
Comparing creative industries in Europe
2016
Creative industries are increasingly understood to contribute to localised innovation and dynamism. This paper provides a methodologically consistent comparison of creative industries across France, Great Britain, Italy and Spain. We map spatial agglomerations of creative activities showing evidence of urban concentration, which for Britain and France coincides with the dominance of capital cities, whilst for Spain and Italy, significant concentrations can also be found in secondary cities. The four countries also differ in the specialisation profiles and in the role played by policy makers. A lack of dove-tailing with the European Union smart agenda is argued to be a cause of concern.
Planification territoriale durable
2017
Au niveau local, la comprehension et le traitement des enjeux environnementaux necessite la mise en place d’approches de plus en plus transversales (pour la definition de strategies, la mise en œuvre de projets, etc.). Cela doit se traduire par un decloisonnement des politiques publiques, via une gestion moins verticale et plus integree des differentes competences de la collectivite. Dans ce contexte, on constate un besoin croissant de donnees de differentes natures, afin d’aider a la decision les pouvoirs publics et leurs parties prenantes, comme par exemple dans le cadre de projets de transformation urbaine. En parallele, on assiste a un elargissement exponentiel des possibilites offertes…
Territorial servitization in Marshallian industrial districts: the industrial district as a place-based form of servitization
2018
This paper is the first general study of territorial servitization in Marshallian industrial districts (MIDs). It introduces the novel idea of place-based servitization as a form of territorial servitization, which is then used conceptually to reframe the traditional perspective on MIDs, manufacturing places par excellence. Drawing on comparable quantitative data from Italy and Spain for 1991, 2001 and 2011, the paper then provides generalizable empirical evidence about the stylized facts of servitization in MIDs, casting a light on the transition to services of the MID as one model of place-based servitization.