Search results for " Regulation"
showing 10 items of 3187 documents
INRA-Dijon reactors for solid state fermentation: Designs and applications
1996
45 ref.; International audience
Terminal tendon cell differentiation requires the glide/gcm complex.
2004
International audience; Locomotion relies on stable attachment of muscle fibres to their target sites, a process that allows for muscle contraction to generate movement. Here, we show that glide/gcm and glide2/gcm2, the fly glial cell determinants, are expressed in a subpopulation of embryonic tendon cells and required for their terminal differentiation. By using loss-of-function approaches, we show that in the absence of both genes, muscle attachment to tendon cells is altered, even though the molecular cascade induced by stripe, the tendon cell determinant, is normal. Moreover, we show that glide/gcm activates a new tendon cell gene independently of stripe. Finally, we show that segment p…
Dual mode of action of grape cane extracts against Botrytis cinerea
2019
International audience; Crude extracts of Vitis vinifera canes represent a natural source of stilbene compounds with well characterized antifungals properties. In our trials, exogenous application of a stilbene extract (SE) obtained from grape canes on grapevine leaves reduces the necrotic lesions caused by Botrytis cinerea. The SE showed to possess a direct antifungal activity by inhibiting the mycelium growth. The activation of some grapevine defense mechanism was also investigated. H2O2 production and activation of mitogen-activated protein kinase (MAPK) phosphorylation cascades as well as accumulation of stilbenoid phytoalexins were explored on grapevine cell suspension. Moreover, the t…
Heat shock factor 2 is a stress-responsive mediator of neuronal migration defects in models of fetal alcohol syndrome
2014
Fetal alcohol spectrum disorder (FASD) is a frequent cause of mental retardation. However, the molecular mechanisms underlying brain development defects induced by maternal alcohol consumption during pregnancy are unclear. We used normal and Hsf2-deficient mice and cell systems to uncover a pivotal role for heat shock factor 2 (HSF2) in radial neuronal migration defects in the cortex, a hallmark of fetal alcohol exposure. Upon fetal alcohol exposure, HSF2 is essential for the triggering of HSF1 activation, which is accompanied by distinctive post-translational modifications, and HSF2 steers the formation of atypical alcohol-specific HSF1–HSF2 heterocomplexes. This perturbs the in vivo bindi…
Cyclopropane Fatty Acid Synthase from Oenococcus oeni: Expression in Lactococcus lactis subsp. Cremoris and Biochemical Characterization
2015
Bacterial cyclopropane fatty acid synthases (CFA synthases) catalyze the transfer of a methyl group from S-adenosyl-L-methionine (AdoMet) to the double bond of a lipid chain, thereby forming a cyclopropane ring. CFAs contribute to resistance to acidity, dryness, and osmotic imbalance in many bacteria. This work describes the first biochemical characterization of a lactic acid bacterium CFA synthase. We have overexpressed Oenococcus oeni CFA synthase in E. coli in order to purify the enzyme. The optimum cyclopropanation activity was obtained at pH 5.6 and 35.8 °C. The high K(m) (AdoMet) value obtained (2.26 mM) demonstrates the low affinity of O. oeni enzyme toward the L. lactis subsp. cremo…
Excluding identities through ethical regulation: A Levinasian analysis of managerial practices to combat ill-treatment
2019
Thème du congrès : « Enlightening the Future:The Challenge for Organizations, Sub-theme 15: ‘Faking It’: Identity Work in an Age of Exclusion; International audience
Pharmaciens et coordination des soins primaires en France : quels enjeux ?
2019
Multi-professional coordination is a strong axis of the reorganization of primary care in France. While this coordination concerns a priori all health professionals, some of them actually are still marginally involved. This article examines the challenges of integrating pharmacists into primary care in France. On the one hand, it is based on an analysis of experiments carried out in other health systems, and on their evaluations. On the other hand, it develops an initial reflection on the levers and obstacles that could explain in France, the poor integration of pharmacists but also on the challenges of a stronger presence of these professionals in the coordination of primary care.
Could the acid-base status of Antarctic sea urchins indicate a better-than-expected resilience to near-future ocean acidification?
2015
13 pages; International audience; Increasing atmospheric carbon dioxide concentration alters the chemistry of the oceans towards more acidic conditions. Polar oceans are particularly affected due to their low temperature, low carbonate content and mixing patterns, for instance upwellings. Calcifying organisms are expected to be highly impacted by the decrease in the oceans' pH and carbonate ions concentration. In particular, sea urchins, members of the phylum Echinodermata, are hypothesized to be at risk due to their high-magnesium calcite skeleton. However, tolerance to ocean acidification in metazoans is first linked to acid–base regulation capacities of the extracellular fluids. No infor…
Cooperation in Managing the Environmental Function in Agriculture as a Condition for Integration of the Borderland Areas of the Czech Republic and Po…
2018
The aim of the study is to justify the need for cooperation in the sphere of managing the environmental function in the agriculture of the borderland areas of Poland and the Czech Republic. Until now, thanks to the so-called “green structure of the Common Agricultural Policy” the environment-related requirements in agriculture have come from the top and have been of the universal character. In the agricultural policy following 2020, it is state governments and multilevel management structures which will have been responsible for programming and implementing environmental and climatic strategies in this sector. In borderland areas, solutions that will be accepted may become a source of confl…
USE OF PASSENGER LOCATION CARDS IN THE ERA OF THE COVID-19 PANDEMIC, AND THE PROCESSING OF PERSONAL DATA OF AIR PASSENGERS
2021
Purpose: The aim of the article is to analyse the processing of personal data of air passengers during the SARS-CoV-2 pandemic in the context of doubts that have arisen in connection with the need for these passengers to provide their personal data as part of filling out the Passenger Location Card questionnaire. Method: The research method used in this study is case study. Findings: In the study, it was showed that firstly, the data of air passengers processed in relation to the application of the Passenger Location Card by the State Border Sanitary Inspectorate in Warsaw should be protected under the provisions of the General Regulation on the protection of personal data. Furthermore, the…