Search results for " Relationships"
showing 10 items of 317 documents
Dopaminergic isoquinolines with hexahydrocyclopenta[ ij ]-isoquinolines as D 2 -like selective ligands
2016
Dopamine receptors (DR) ligands are potential drug candidates for treating neurological disorders including schizophrenia or Parkinson's disease. Three series of isoquinolines: (E)-1-styryl-1,2,3,4-tetrahydroisoquinolines (series 1), 7-phenyl-1,2,3,7,8,8a-hexahydrocyclopenta[ij]-IQs (HCPIQs) (series 2) and (E)-1-(prop-1-en-1-yl)-1,2,3,4- tetrahydroisoquinolines (series 3), were prepared to determine their affinity for both D1and D2-like DR. The effect of different substituents on the nitrogen atom (methyl or allyl), the dioxygenated function (methoxyl or catechol), the substituent at the β-position of the THIQ skeleton, and the presence or absence of the cyclopentane motif, were studied. We…
Homology models of melatonin receptors: challenges and recent advances
2013
Melatonin exerts many of its actions through the activation of two G protein-coupled receptors (GPCRs), named MT1 and MT2. So far, a number of different MT1 and MT2 receptor homology models, built either from the prototypic structure of rhodopsin or from recently solved X-ray structures of druggable GPCRs, have been proposed. These receptor models differ in the binding modes hypothesized for melatonin and melatonergic ligands, with distinct patterns of ligand-receptor interactions and putative bioactive conformations of ligands. The receptor models will be described, and they will be discussed in light of the available information from mutagenesis experiments and ligand-based pharmacophore …
We Become People in Architecture
2016
Attraverso lo studio del Catalogo Breve del 12 ° Mostra Internazionale di Architettura della Biennale di Venezia del 2010, People meet in Architecture, sotto la direzione di Kazuyo Sejima, cercheremo di interpretare: un lavoro scritto, dei disegni e alcune foto. La Mostra ha permesso ai visitatori di conoscere idee derivanti da diversi contesti con un presupposto che l'architettura, come spazio costruito per gli stili di vita in continua evoluzione, è sempre stato uno specchio della coscienza collettiva. Per mezzo di questo lavoro cercheremo di capire come i contenuti della Mostra, di cui con l'uso della essenzialità grafica di un catalogo, consente di conoscere e studiare piani intrisi di …
New Families as an Educational Emergency
2017
One phenomenon typical of late-modern Western societies is the extreme pluralisation of family forms, a true and proper archipelago of families, so that: the family can no longer be reasonably discussed in the singular, just as well as each couple seems to form a «mixed couple» . Observing the data describing this phenomenon and any perceived trends, prompt a first general consideration, from an educational perspective: the aspects related to couple formation, the choice of whether to marry, the preferred family forms, all highlight a breakup between the older and the younger generations. In short, we are confronted with a new culture of human relationships: this new culture sets new symbol…
Ether-Lipids Are Involved in Retinal Vegf Expression and in Postnatal Hyaloid Vessel Regression
2009
Purpose:Ether-lipids are phospholipids that represent about 13% of retinal lipids and whose exact functions remain unknown. However, the preferential esterification of polyunsaturated fatty acids (PUFAs) at the sn-2 position of ether-lipids and their liberation by an ether-lipid-specific phospholipase A2 suggest their involvement in cell signaling processes. Based on the data showing the persistence of the hyaloid vasculature in ether-lipid-deficient mice (DAPAT-/- mice, Rodemer et al Hum Mol Genet 2003), we further investigated the molecular mechanisms by which ether-lipids may regulate hyaloid vessels regression during post-natal development. Methods:C57BL/6 mice were treated at birth eit…
Simple Relationships for the Optimal Design of Paired Drip Laterals on Uniform Slopes
2016
Microirrigation plants, if properly designed, allow water use efficiency to be optimized and quite high values of emission uniformity to be obtained in the field. It is known that disposing paired laterals, in which two distribution pipes extend in opposite directions from a common manifold, contribute to increasing water use efficiency. Recently, an analytical procedure has been proposed to optimally design paired drip laterals on uniform slopes under the assumption of neglect: (1) the variations of the emitters’ flow rate along the lateral, and (2) the local losses due to the emitters’ insertions. However, this procedure is not readily usable for every geometric and hydraulic characterist…
The logic of the gift and the bonding value: a new perspective for business management
2011
PurposeThis paper aims to conceptualize business relationships so as to include in these dimensions of both gift and gratuity, to develop the concept of “bonding value”, and to offer some ideas for the use of this within firms.Design/methodology/approachThe paper analyses the concept of “bonding value”, distinguishing it from the concepts of “exchange value” and “use value” that are normally used in business, and attempts to investigate its practical implications.FindingsThe paper shows how evaluating both the relationships within the organization and between firm and stakeholders in terms of “bonding value” can have effects on the economic, organizational and social aspects of a firm's act…
Making and breaking relationships on social media: the impacts of brand and influencer betrayals
2021
This study considers how the relationships between social media influencers, brands and individuals are intertwined on social media and analyses the spill-over effects of feelings of betrayal. An experimental design with two transgression scenarios (influencer vs. brand) was created, and 250 individuals were recruited to participate in the study. The results show that a perceived betrayal by a brand can negatively affect the perceived coolness of the social media influencer that has endorsed the brand, as well as the parasocial relationships that followers have with the influencer. Accordingly, a perceived betrayal by a social media influencer can negatively affect attitudes, trust and purc…
La incorporación de la perspectiva de género en la docencia universitaria del Grado en Relaciones Laborales y Recursos Humanos de la Universitat de V…
2020
[ES] En esta comunicación presentamos el Projecte d’Innovació Docent (PID) interuniversitari «Incorporar la Perspectiva de Gènere en la Docència Universitària del Grau en Relacions Laborals com a element d’Innovació i Pràctica de bona ciència» desarrollado en la Universitat de València. Este PID nace con la intención de dar impulso a la implantación de la perspectiva de género, de forma transversal, en la enseñanza del Grado en Relaciones Laborales y Recursos Humanos. Incorporar la perspectiva de género es necesario para formar profesionales en el mundo del trabajo. Los análisis de género con carácter integral son un elemento de Innovación de última generación que están logrando dar respues…
Theorising love in sociological thought: Classical contributions to a sociology of love
2017
This article sets out to explore the contributions of classical social thinkers to a sociological understanding of love. It builds on the premise that despite its major relevance and consequential importance in shaping both individual lives and the social world, until recently love was a heavily undertheorised topic in the sociological tradition. Moreover, the body of disparate sociological reflections that have been made on the social nature of love has been largely forgotten in the discipline’s intellectual legacy. The article then proceeds in unearthing the classics’ contributions to a sociology of love. It starts with Max Weber’s view that love promises to be a means of sensual salvati…