Search results for " Repair"
showing 10 items of 721 documents
USO DELLA TUNICA VAGINALE DEL TESTICOLO NELLA CHIRURGIA DELL'IPOSPADIA
1993
Urethrocutaneus fistulas are the most common complication of surgery for hypospadias. In five patients, fistulas of this type were repaired with patches of tunica vaginalis to prevent fistula recurrence. Our experience and that of others suggest that tunica vaginalis autografts can be used for treatment of a variety of urethral problems in children.
Chimney endografting for pararenal aortic pathologies using transfemoral access and the lift technique
2013
Purpose: To present a technique for transfemoral implantation of parallel grafts into the renal arteries in patients with anatomy or morphology that blocks standard antegrade chimney graft delivery. Technique: In a totally percutaneous approach, a 5-F pigtail angiographic catheter is passed into the aorta above the renal arteries via a 0.035-inch hydrophilic guidewire, followed by an 8-F sheath. The target vessel is cannulated with the hydrophilic wire followed by a 5-F reverse curve catheter; the wire is changed for a Rosen wire. The main stent-graft body is delivered and parked at the level of the aortic bifurcation. The Viabahn chimney endograft is advanced ~1 to 2 cm into the target ren…
The effectiveness of 12 months' intensive shoulder strength training on disability, health-related quality of life and shoulder function after rotato…
2017
This study examined the effectiveness of intensive shoulder strength training on disability, health-related quality of life (HRQoL) and shoulder function in patients who had undergone rotator cuff repair (RCR). In addition, the self- report section of the American Shoulder and Elbow Surgeons Standardized Assessment Form (ASES) was cross-culturally adapted to the Finnish language and the psychometric properties of the Finnish version were assessed. Patients with a rotator cuff tear (aged 41-62 years) were randomized into an exercise group (EG, n=35) or a usual care group (UCG, n=32) after RCR. Disability was assessed with ASES questionnaire and quality of life with Short- Form 36 Health Surv…
Enhancement of lysine acetylation accelerates wound repair
2013
In physiopathological conditions, such as diabetes, wound healing is significantly compromised and chronic complications, including ulcers, may occur. In a mouse model of skin repair, we recently reported that wound treatment with Sirtuin activators and class I HDAC inhibitors induced keratinocyte proliferation and enhanced healing via a nitric oxide (NO) dependent mechanism. We observed an increase in total protein acetylation in the wound area, as determined by acetylation of α-tubulin and histone H3 Lysine 9. We reasoned that this process activated cell function as well as regulated gene expression to foster tissue repair. We report here that the direct activation of P300/CBP-associated …
The tumor-agnostic treatment for patients with solid tumors: a position paper on behalf of the AIOM- SIAPEC/IAP-SIBioC-SIF Italian Scientific Societi…
2021
The personalized medicine is in a rapidly evolving scenario. The identification of actionable mutations is revolutionizing the therapeutic landscape of tumors. The morphological and histological tumor features are enriched by the extensive genomic profiling, and the first tumor-agnostic drugs have been approved regardless of tumor histology, guided by predictive and druggable genetic alterations. This new paradigm of "mutational oncology", presents a great potential to change the oncologic therapeutic scenario, but also some critical aspects need to be underlined. A process governance is mandatory to ensure the genomic testing accuracy and homogeneity, the economic sustainability, and the r…
Molecular mechanisms of sorafenib action in liver cancer cells.
2012
Sorafenib, a multikinase inhibitor, recently received FDA approval for the treatment of advanced hepatocellular carcinoma (HCC). However, as the clinical application of sorafenib evolves, there is increasing interest in defining the mechanisms underlying its anti-tumor activity. Considering that this specific inhibitor could target unexpected molecules depending on the biologic context, a precise understanding of its mechanism of action could be critical to maximize its treatment efficacy, while minimizing adverse effects. Two human HCC cell lines (HepG2 and Huh7), carrying different biological and genetic characteristics, were used in this study to examine the intracellular events leading …
Right diaphragmatic injury and lacerated liver during a penetrating abdominal trauma: case report and brief literature review
2014
Introduction: Diaphragmatic injuries are rare consequences of thoracoabdominal trauma and they often occur in association with multiorgan injuries. The diaphragm is a difficult anatomical structure to study with common imaging instruments due to its physiological movement. Thus, diaphragmatic injuries can often be misunderstood and diagnosed only during surgical procedures. Diagnostic delay results in a high rate of mortality. Methods: We report the management of a clinical case of a 45-old man who came to our observation with a stab wound in the right upper abdomen. The type or length of the knife used as it was extracted from the victim after the fight. CT imaging demonstrated a right hem…
Experimental investigation on BFRCM confinement of masonry cylinders and comparison with BFRP system
2021
Abstract Fabric reinforced cementitious mortar (FRCM) materials have started to be employed during the last years with the aim of overcoming the drawbacks related to the use of fibre reinforced polymer (FRP) composites, proving to be potentially suitable for strengthening masonry structures. Moreover, the will to develop materials able to guarantee a certain degree of sustainability without renouncing to adequate mechanical properties has drawn the attention to the use of basalt fibres, which appear to be a valid alternative to carbon or glass fibres. This work presents an experimental investigation on a basalt FRCM (BFRCM) system to confine circular masonry columns, aimed at evaluating the…
Novel Immunomodulatory Markers Expressed by Human WJ-MSC: an Updated Review in Regenerative and Reparative Medicine.
2012
Mesenchymal (stromal) stem cells (MSC) are a broad class of stromal populations which are able to differentiate towards mature cell types, and do express molecules involved in immune modulation, tolerance induction and inflammation dampening. MSC can be virtually isolated from each adult organ, as well as from foetus-associated perinatal tissues. In particular, Wharton's jelly-derived MSC (WJ-MSC) bear all of these key properties, together with their ease of sourcing and lack of ethical issues. Cellular therapy is a key technique in regenerative medicine approaches, in particular for the treatment of diseases in which physiological processes of cellular repopulation are blocked by the under…