Search results for " Replacement"
showing 10 items of 539 documents
Italian Association of Sleep Medicine (AIMS) position statement and guideline on the treatment of menopausal sleep disorders
2019
Insomnia, vasomotor symptoms (VMS) and depression often co-occur after the menopause, with consequent health problems and reductions in quality of life. The aim of this position statement is to provide evidence-based advice on the management of postmenopausal sleep disorders derived from a systematic review of the literature. The latter yielded results on VMS, insomnia, circadian rhythm disorders, obstructive sleep apnea (OSA) and restless leg syndrome (RLS). Overall, the studies show that menopausal hormone therapy (MHT) improves VMS, insomnia, and mood. Several antidepressants can improve insomnia, either on their own or in association with MHT; these include selective serotonin reuptake …
Sociālā funkcionēšana pēc aortas vārstuļa protezēšanas vēlīnajā pēcoperācijas periodā
2017
Pētījuma „Sociālā funkcionēšana pēc aortas vārstuļa protezēšanas vēlīnajā pēcoperācijas periodā” mērķis ir izpētīt sociālo funkcionēšanu pēc aortas vārstuļa protezēšanas vēlīnajā pēcoperācijas periodā un noteikt baiļu iespējamo ietekmi sociālās funkcionēšanas rādītājos. Kvantitatīvā pētījuma rezultātā hipotēzes tiek galvenokārt apstiprinātas. Iegūtie dati raksturo fizisko un emocionālo pašsajūtu, attiecības ar līdzcilvēkiem un dzīvesveidu pēc aortas vārstuļa protezēšanas, kā arī baiļu ietekmi uz šiem rādītājiem. Tiek secināts, ka ir nepieciešama pacientu izglītošana pēc operācijas un pirmspensijas vecums ir kritiskākā vecuma grupa, kurai ir problēmas ar kaitīgo ieradumu praktizēšanu un atgr…
TCT-43 First-in-human experience of a novel transradial device for embolic deflection during transcatheter aortic valve replacement
2018
The average stroke rate in contemporary transcatheter aortic valve replacement (TAVR) studies is 4.4%. The majority of the TAVR studies are non-randomized registries, hence, neurological outcomes may be underreported. Over 50% of all TAVR related strokes occur during the procedure or on the same day
Wound drainages in total hip arthroplasty: to use or not to use? Review of the literature on current practice.
2013
Aim of this study is to analyze data reported in literature concerning the efficacy of using wound low-vacuum suction drainages in orthopedic surgery after total hip arthroplasty. We analyzed studies concerning the use of drainages in prosthetic hip replacement surgery, performing our research through Pubmed, Cochrane database and Google Scholar, and selecting the ones evaluating the following parameters: bleeding, the need for blood transfusions, number or reinforcement of post-operative medications, length of hospitalization, functional results, periprosthetic and surgical wound infection, post-operative hematoma. Our review did not show any demonstrated advantage from the use of wound dr…
Source document verification in the Mucopolysaccharidosis Type I Registry
2011
Purpose The Mucopolysaccharidosis Type I (MPS I) Registry is an international observational database that tracks the natural history and the outcomes of patients with MPS I. The Registry was a regulatory requirement following the approval of laronidase enzyme replacement therapy for MPS I in 2003. All data are collected voluntarily after informed consent from the patient or family. Data are checked through queries, monthly reviews, and electronic audits to identify missing, inconsistent, or invalid data. This analysis sought to determine overall data accuracy in the Registry through source document verification (SDV). Methods Two phases of SDV were performed. In each phase, Registry data we…
Stem cell replacement therapy in type 1 diabetes
2007
Type 1 diabetes is caused by the autoimmune destruction of pancreatic insulin-producing beta cells and most frequently occurs in genetically susceptible children. Due to beta cell loss, Type 1 diabetes is an ideal candidate for cell replacement therapy. Replacement could be achieved via whole pancreas or isolated islet transplantation, but, at present, feasibility of these procedures is severely limited by the shortage of donor pancreata. Stem cells, characterized by their high potential for self-renewal and the simultaneous ability to differentiate into a desired cytotype, theoretically represent a suitable and renewable source of surrogate beta cells. However, despite many promising resul…
Diagnosis of papillary muscle rupture after acute myocardial infarction by transthoracic and transesophageal echocardiography.
1993
The sensitivity of transthoracic echocardiography to visualize the structural abnormality of papillary muscle rupture (PMR) after acute myocardial infarction can be anticipated to average about 50%; therefore, we evaluated five patients exhibiting the condition with both transthoracic and transesophageal echocardiography. The use of the two imaging techniques resulted in the fact that no instance of PMR was missed. Using transthoracic echocardiography in two patients and transesophageal echocardiography in four, the ruptured papillary muscle was visualized directly. Mitral insufficiency as an indirect sign was observed in all patients. In one patient the papillary muscle rupture developed i…
The Artificial Kidney Initiation in Kidney Injury 2 (AKIKI2): study protocol for a randomized controlled trial
2019
Abstract Background The Artificial Kidney Initiation in Kidney Injury (AKIKI) trial showed that a delayed renal replacement therapy (RRT) strategy for severe acute kidney injury (AKI) in critically ill patients was safe and associated with major reduction in RRT initiation compared with an early strategy. The five criteria which mandated RRT initiation in the delayed arm were: severe hyperkalemia, severe acidosis, acute pulmonary edema due to fluid overload resulting in severe hypoxemia, serum urea concentration > 40 mmol/l and oliguria/anuria > 72 h. However, duration of anuria/oliguria and level of blood urea are still criteria open to debate. The objective of the study is to compar…
STRUCTURAL ANALYSIS OF A POSTERIOR STABILITY TOTAL KNEE JOINT REPLACEMENT
2011
Aim of this work is to compare two different total knee prostheses that differ in the shape of the Polyethylene (PE) insert, trying to optimize the shape of the best one, in order to reduce the stress peaks. The study procedure has been divided into the following steps. First step has been the three-dimensional shape acquisition of the two prostheses by means of a COMET5 3D scanner. The morphology of two prototypes of the prostheses has been acquired by elaborating multiple Moirè fringe pattern projected on their surfaces. Second step consisted of the manipulation of these data in a CAD module, that is the interpolation of raw data into parametric surfaces, reducing singularities due to the…
Study of a constrained finite element elbow prosthesis: the influence of the implant placement
2023
Abstract Background The functional results of total elbow arthroplasty (TEA) are controversial and the medium- to long-term revision rates are relatively high. The aim of the present study was to analyze the stresses of TEA in its classic configuration, identify the areas of greatest stress in the prosthesis–bone–cement interface, and evaluate the most wearing working conditions. Materials and methods By means of a reverse engineering process and using a 3D laser scanner, CAD (computer-aided drafting) models of a constrained elbow prosthesis were acquired. These CAD models were developed and their elastic properties, resistance, and stresses were studied through finite element analysis (fin…