Search results for " Reti"
showing 10 items of 868 documents
CONFRONTO TRA UN MODELLO DINAMICO ED UNO STAZIONARIO NELLA VALUTAZIONE DELLE PERDITE REALI ED APPARENTI DI UNA RETE DI DISTRIBUZIONE
2012
Nel presente articolo è stato applicato un modello dinamico di simulazione idraulica delle reti di distribuzione per la valutazione delle perdite idriche reali ed apparenti. Sono stati sviluppati uno modello di domanda al nodo che simula i serbatoi privati ed un modulo per la stima delle perdite apparenti. Le perdite reali sono state modellate attraverso una relazione generale che esprime la portata effluente dalla perdita come una funzione della pressione. I risultati ottenuti sono stati confrontati con le stime modellistiche basate su di un approccio stazionario.
VEGF faktoru atklāšana acs priekšējas kameras šķidrumā - norma un patoloģija
2019
Ievads: Asinsvadu neovaskularizācija ir grūts process, kur galvenais mehānisms ir VEGF izdalīšana, kas nodrošina barības vielu un skābekļa transportēšanu. Tas ir pamats daudziem fizioloģiskiem un patoloģiskiem procesiem. Acs audos VEGF darbības izpēte ir aktuāla tēma, jo patoloģiski paaugstināts VEGF norāda uz hipoksijas apstākļiem audos, un VEGF līmeņa mērīšana var dot informāciju par išēmiju, prognostisko attīstību, kas savukārt sekmē laicīgo terapijas uzsākšanu, lai samazinātu iespējamās blakusparadības. Pētījuma mērķis: Noteikt VEGF līmeni acu priekšējā kamerā kontrolgrupas pacientiem ar kataraktas diagnozi, bez citām acu saslimšanām, un salīdzināt ar literatūras iegūtajiem rezultātiem,…
Production of cecropin A in transgenic rice plants has an impact on host gene expression.
2008
Summary Expression of the cecropin A gene in rice confers resistance to the rice blast fungus Magnaporthe oryzae. In this study, a polymerase chain reaction-based suppression subtractive hybridization approach was used to generate a cDNA macroarray from the elite japonica rice (Oryza sativa L.) cultivar ‘Senia’. Gene expression studies revealed that the expression of components of the protein secretory and vesicular transport machinery is co-ordinately activated at the pre-invasive stage of infection of rice by the blast fungus. Comparisons of gene expression between wild-type and cecropin A plants revealed the over-expression of genes involved in protection against oxidative stress in tran…
The pathophysiology of intestinal lipoprotein production
2015
Intestinal lipoprotein production is a multistep process, essential for the absorption of dietary fats and fat-soluble vitamins. Chylomicron assembly begins in the endoplasmic reticulum with the formation of primordial, phospholipids-rich particles that are then transported to the Golgi for secretion. Several classes of transporters play a role in the selective uptake and/or export of lipids through the villus enterocytes. Once secreted in the lymph stream, triglyceride-rich lipoproteins (TRLs) are metabolized by Lipoprotein lipase (LPL), which catalyzes the hydrolysis of triacylglycerols of very low density lipoproteins (VLDLs) and chylomicrons, thereby delivering free fatty acids to vario…
Mitochondria and T2D: Role of Autophagy, ER Stress, and Inflammasome.
2020
Type 2 diabetes (T2D) is one of the main current threats to human health. Both T2D and its numerous clinical complications are related to mitochondrial dysfunction and oxidative stress. Over the past decade, great progress has been made in extending our knowledge about the signaling events regulated by mitochondria. However, the links among mitochondrial impairment, oxidative stress, autophagy, endoplasmic reticulum (ER) stress, and activation of the inflammasome still need to be clarified. In light of this deficit, we aim to provide a review of the existing literature concerning the complicated crosstalk between mitochondrial impairment, autophagy, ER stress, and the inflammasome in the mo…
The Role of Autophagy in Eye Diseases
2021
Autophagy is a catabolic process that ensures homeostasis in the cells of our organism. It plays a crucial role in protecting eye cells against oxidative damage and external stress factors. Ocular pathologies of high incidence, such as age-related macular degeneration, cataracts, glaucoma, and diabetic retinopathy are of multifactorial origin and are associated with genetic, environmental factors, age, and oxidative stress, among others; the latter factor is one of the most influential in ocular diseases, directly affecting the processes of autophagy activity. Alteration of the normal functioning of autophagy processes can interrupt organelle turnover, leading to the accumulation of cellula…
Separation of chitosomes and secretory vesicles from the ?slime? variant of Neurospora crassa
1987
Cells from the “slime” variant of Neurospora crassa were broken in isotonic conditions by use of triethanolamine buffer plus EDTA. After removal of large membranous structures by low-speed centrifugation, chitosomes and secretory vesicles were separated by means of gel filtration, precipitation of membranous contaminants with Concanavalin A, and centrifugation in sucrose or glycerol gradients. Polypeptidic composition of fractions enriched in secretory vesicles or chitosomes was found to be distinct. By these criteria we concluded that chitosomes and secretory vesicles represent different populations of microvesicles. Both microvesicular populations appeared free of endoplasmic reticulum an…
Grp78 overexpression triggers pink1-ip3 r-mediated neuroprotective mitophagy
2021
An experimental model of spinal root avulsion (RA) is useful to study causal molecular programs that drive retrograde neurodegeneration after neuron-target disconnection. This neurode-generative process shares common characteristics with neuronal disease-related processes such as the presence of endoplasmic reticulum (ER) stress and autophagy flux blockage. We previously found that the overexpression of GRP78 promoted motoneuronal neuroprotection after RA. After that, we aimed to unravel the underlying mechanism by carrying out a comparative unbiased proteomic analysis and pharmacological and genetic interventions. Unexpectedly, mitochondrial factors turned out to be most altered when GRP78…
LU FMOF optometrijas un redzes zinātnes nodaļas un Latvijas optometristu un optiķu asociācijas konferenču referātu tēzes
2020
Tēzes no LU 78.starptautiskās zinātniskās konferences Cilvēka fizioloģijas un uztveres sēdes un LU Optometrijas un redzes zinātnes nodaļas un LOOA kopīgās klīniski praktiskās konferences Rīgā, 2020.gada 14., 16. februārī
Dissecting the Mechanism of Action of Spiperone—A Candidate for Drug Repurposing for Colorectal Cancer
2022
Approximately 50% of colorectal cancer (CRC) patients still die from recurrence and metastatic disease, highlighting the need for novel therapeutic strategies. Drug repurposing is attracting increasing attention because, compared to traditional de novo drug discovery processes, it may reduce drug development periods and costs. Epidemiological and preclinical evidence support the antitumor activity of antipsychotic drugs. Herein, we dissect the mechanism of action of the typical antipsychotic spiperone in CRC. Spiperone can reduce the clonogenic potential of stem-like CRC cells (CRC-SCs) and induce cell cycle arrest and apoptosis, in both differentiated and CRC-SCs, at clinically relevant co…