Search results for " Reti"
showing 8 items of 868 documents
Evaluación preclínica de la toxicidad retiniana en la administración intravítrea de ácido docosahexaenoico en modelo experimental de conejo
2013
Objetivo: Evaluar la toxicidad retiniana a corto plazo de la administración intravítrea de una dosis única de ácido docosahexaenoico (DHA) en un modelo experimental de conejo. Material y métodos: Dieciséis conejos albinos Nueva Zelanda fueron seleccionados para este estudio toxicológico preclínico. Se prepararon seis concentraciones de DHA (Brudy Laboratorios, Barcelona, España): 10mg/50μl, 5mg/50μl, 2'5mg/50μl, 50μg/50μl, 25μg/50μl, 5μg/50μl. Cada concentración fue inyectada por vía pars plana en inyección intravítrea en el ojo derecho de dos conejos. La solución vehículo se inyectó en el ojo derecho de cuatro animales que se consideraron el grupo control. Se evaluó la seguridad retiniana …
Esferocitosis hereditaria en niños: análisis de las características clínicas, analíticas, terapéuticas y evolutivas. Evaluación de nuevas técnicas di…
2023
La Esferocitosis Hereditaria (EH) es la anemia hemolítica crónica más frecuente en el mundo. Se produce por una alteración de las proteínas de membrana del eritrocito, lo que le confiere una menor capacidad para deformarse al hematíe y por tanto una vida media más corta. La hemólisis crónica mantenida produce anemia, ictericia y esplenomegalia. La EH se puede dividir en grupos según su gravedad (leve, moderado, grave) en función de sus valores de hemoglobina, reticulocitos y bilirrubina. La enfermedad de Gilbert se produce por una disminución de la glucuronización de la bilirrubina, produciendo un aumento de bilirrubina e ictericia clínica. Su asociación con la EH será uno de los objetivos …
Transfection of lipoma cells with papilloma bovine virus subgenomic fragment.
1991
Abstract Lipoma cells with consistent chromosomal aberration have been transfected with plasmids carrying papilloma bovine virus subgenomic fragment (PBV 69). The succesful transformation of the cells was ascerted on the changed growth pattern of the cells in liquid medium, colony formation in soft agar and modified cell appearrance in electron microscopy; transfection with PBV 69 has not been, however, sufficient to immortalize lipoma cells.
Lipid Binding Controls Dimerization of the Coat Protein p24 Transmembrane Helix
2019
Abstract Coat protein (COP) I and COP II complexes are involved in the transport of proteins between the endoplasmic reticulum and the Golgi apparatus in eukaryotic cells. The formation of COP I/II complexes at membrane surfaces is an early step in vesicle formation and is mastered by p24, a type I transmembrane protein. Oligomerization of p24 monomers was suggested to be mediated and/or stabilized via interactions within the transmembrane domain, and the p24 transmembrane helix appears to selectively bind a single sphingomyelin C18:0 molecule. Furthermore, a potential cholesterol-binding sequence has also been predicted in the p24 transmembrane domain. Thus, sphingomyelin and/or cholestero…
Colonization of adrenal glands and ovaries of mice by variants of HSV 1 and 2
1991
The herpes simplex virus (HSV)-infected mouse model was used to correlate histopathological lesions in adrenal glands and ovaries with the localisation of viral nucleic acids and viral antigens, employing in situ hybridization and immunohistochemistry. In the adrenals, the lesions were mainly restricted to the zona fasciculata and the zona reticularis, sometimes extending to the medulla. In the ovaries, lesions were detected in follicles and in the stroma. During the course of infection, HSV nucleic acids could be detected earlier than HSV proteins. Next to the center of necrotic foci mainly HSV proteins were detected, whereas peripheral cells were found to contain viral nucleic acids. In s…
Anatomic and functional follow-up of patients with an idiopathic epiretinal membrane and a preserved visual acuity
2013
Purpose: To determine the anatomic and functional retinal modifications in patients with an idiopathic epiretinal membrane (ERM) and a preserved visual acuity (VA).Methods: Monocentric, prospective study in 24 eyes of 24 patients with an ERM and a VA better than 20/25. Recorded data were best corrected VA on ETDRS scale, retinal anatomic lesions on spectral-domain OCT, retinal sensitivities on microperimetry and macular and foveal thicknesses at 0 and 6 months.Results: At inclusion, mean VA was 84 ± 5 letters, mean macular sensitivity was 14.0 ± 1.4 decibels (dB) and mean foveal sensitivity was 14,4 ± 1,5 dB. Mean macular thickness was 351 ± 34 µm and mean foveal thickness was 348 ± 66 µm. …
Scleral Buckling: A Review of Clinical Aspects and Current Concepts
2021
Scleral buckling represents a valuable treatment option for rhegmatogenous retinal detachment repair. The surgery is based on two main principles: the closure of retinal breaks and the creation of a long-lasting chorioretinal adhesion. Buckles are placed onto the sclera with the purpose of sealing retinal breaks. Cryopexy is usually performed to ensure a long-lasting chorioretinal adhesion. Clinical outcomes of scleral buckling have been shown to be more favorable in phakic eyes with uncomplicated or medium complexity retinal detachment, yielding better anatomical and functional results compared with vitrectomy. Several complications have been described following scleral buckling surgery, s…
The AQP2 mutation V71M causesnephrogenic diabetes insipidus in humans but does not impair the function of a bacterial homolog
2015
Graphical abstract