Search results for " Reti"
showing 10 items of 868 documents
Il capitale sociale e la rete partecipativa
2008
Nella “regia” della curatrice il tema del capitale sociale è messo in relazione alle reti comunicative dei new media e alle stesse culture di partecipazione che animano la società civile. L’ampiezza di orizzonti interpretativi in cui il concetto di capitale sociale viene declinato in ambito pluridisciplinare, trova nel volume una reductio sensu, una recinzione categorematica che lo interrela anche alla società meridionale e ai cambiamenti in essa verificatisi nel corso degli ultimi anni. Studiosi autorevoli (Colozzi, De Nicola, Boccia Altiri, Ferrucci, Bartholini et Al.) si confrontano quindi all’interno di una tripartizione concettuale, tracciata dalla curatrice, che mette in relazione le …
Hypusinated eIF5A is required for the translation of collagen.
2021
ABSTRACT Translation of mRNAs that encode peptide sequences with consecutive prolines (polyproline) requires the conserved and essential elongation factor eIF5A to facilitate the formation of peptide bonds. It has been shown that, upon eIF5A depletion, yeast ribosomes stall in polyproline motifs, but also in tripeptide sequences that combine proline with glycine and charged amino acids. Mammalian collagens are enriched in putative eIF5A-dependent Pro-Gly-containing tripeptides. Here, we show that depletion of active eIF5A in mouse fibroblasts reduced collagen type I α1 chain (Col1a1) content, which concentrated around the nuclei. Moreover, it provoked the upregulation of endoplasmic reticul…
Temporal aspects of the O-glycosylation of Saccharomyces cerevisiae mannoproteins
1986
Abstract Cleavage of the O-glycosyl bonds of Saccharomyces cerevisiae cell wall mannoproteins by β-elimination resulted in the release of about 8% of the carbohydrate in the form of mannose and other low molecular weight oligomannosaccharides (mannose to mannopentaose), leaving 92% mannose still covalently linked to the peptide, and suggesting that this alkali-resistant fraction was N-glycosidically linked. At the non-permissive temperature, S. cerevisiae sec mutants accumulated in the cytoplasm mannoproteins with different degrees of O- and N-glycosylation. The glycoproteins of mutant sec 20-1 contained 60% of the carbohydrate linked by N-bonds, the remainder being O-glycosidically linked.…
Proteins and enzymes of the peroxisomal membrane in mammals.
1993
Proteins of the peroxisomal membrane can be schematically divided into two groups, one being made up of more or less characterized proteins with generally unknown functions and the other consisting of enzyme activities of which the corresponding proteins have not been characterized. In the present report, these proteins and enzymes are described with the addition of unpublished results regarding their induction by peroxisome proliferators at the post-transcriptional level. Integral membrane proteins (IMPs) can be isolated using an alkaline solution of sodium carbonate. A dozen of preponderant IMPs can be seen on sodium dodecyl sulfate polyacrylamide gel electrophoresis, and the major band c…
Oxidative stress in diabetic retinopathy
2020
Diabetic retinopathy (DR) is the leading cause of acquired blindness in working adults worldwide. Biochemical changes in DR contribute to both the microscopic structural and functional changes in the retina. All these alterations result in retinal damage that can be assessed by funduscopy, optical coherence tomography (OCT), and angioOCT. Reactive oxygen species (ROS) overproduction in the mitochondria is considered a causal link between elevated glucose and biochemical abnormalities in the pathophysiology of DR. Moreover, oxidative-induced pathways also seem to provide positive feedback to ROS production, resulting in a vicious cycle. ROS can directly damage lipids, proteins, and DNA, lead…
Polyunsaturated fatty acids and Plasmalogens in diabetics
2012
Purpose Plasmalogens (PLS) are phospholipids characterized by a vinyl ether bond and a preferential esterification of polyunsaturated fatty acids (PUFA). We have previously shown that the lack of PLS leads to retinal hyper-capillarization. We hypothesize that PLS are negative regulators of vascular development, and aimed to check their circulating levels in diabetic patients. Methods Blood samples were collected from 88 patients and 14 control subjects. Among diabetics we had 14 patients without diabetic retinopathy (DR), 12 with a mild non proliferative DR, 12 with a moderate non proliferative DR, 22 with a severe non proliferative DR and 24 with a proliferative DR (PDR). Erythrocytes were…
Diabetic Retinopathy and Oxidative Stress
2014
Abstract Diabetic retinopathy (DR) is the leading cause of acquired blindness in working age adults worldwide. Biochemical changes in DR contribute to both the microscopic structural and functional changes in the retina. All these alterations result in macroscopic retinal damage that can be assessed by funduscopy. The overproduction of reactive oxygen species (ROS) in the mitochondria is considered a causal link between elevated glucose and biochemical abnormalities in the pathophysiology of DR. Moreover, oxidatively induced pathways also seem to provide positive feedback to ROS production, resulting in a vicious cycle. ROS can directly damage lipids, proteins and DNA, leading to cell death…
Modelli ed evoulzione delle politiche
2008
Questo contributo propone alcune riflessioni utili all’inquadramento ed alla valutazione delle politiche a sostegno dell’innovazione. L’attenzione viene posta, in particolare, sull’evoluzione dello scenario nel quale opera l’impresa innovativa, sul ruolo di alcune tipologie di agglomerazioni emerse in questo nuovo scenario, quali le reti per l’innovazione ed i distretti tecnologici, sui sistemi territoriali innovativi nei quali i processi istituzionali hanno un ruolo sempre più importante, come nel caso dei sistemi d’innovazione nazionale e regionale, ed infine sulla questione dell’identificazione e della misurazione dei fattori chiave dell’innovazione utili per una valutazione delle politi…
Beneficial effects of saffron (
2020
Saffron (Crocus sativus L.) has been traditionally used in food preparation and as a medicinal plant. It currently has numerous therapeutic properties attributed to it, such as protection against ischemia, as well as anticonvulsant, antidepressant, anxiolytic, hypolipidemic, anti-atherogenic, anti-hypertensive, antidiabetic, and anti-cancer properties. In addition, saffron has remarkable beneficial properties, such as anti-apoptotic, anti-inflammatory and antioxidant activities, due to its main metabolites, among which crocin and crocetin stand out. Furthermore, increasing evidence underwrites the possible neuroprotective role of the main bioactive saffron constituents in neurodegenerative …
Trabajo y TIC en los mayores de 45 años. Un análisis de la introducción al ciberespacio desde la esfera laboral
2018
The inequality in access to cyberspace due to age at the beginning of the twenty-first century was followed by an economic crisis that intensified many socio-labor dynamics. Through a contextualization with INE data and a qualitative sample, the following work tries to capture the attitudes about ICT related to their previous labor trajectories on those over 45 years of age; and, on the other hand, its introduction to cyberspace from work as a conditioner in the perception of crisis, the maintenance of employment or their way out to retirement.