Search results for " SARS"
showing 9 items of 229 documents
Impact of COVID-19 in AChR Myasthenia Gravis and the Safety of Vaccines: Data from an Italian Cohort.
2022
Background and aims. Patients with Myasthenia gravis (MG) are considered vulnerable as they may present with respiratory muscle weakness and because they are on immunosuppressive treatment; thereby, COVID-19 may have a detrimental effect on these patients. Vaccines against COVID-19 are currently available and it has been shown as they can prevent severe COVID-19 in vulnerable patients. Notwithstanding their efficacy, vaccine hesitancy has not been completely dispelled in the general population. Unfortunately, there is limited data about the safety of these vaccines in MG patients. The aims of this study are to evaluate the impact of COVID-19 in a MG cohort, the adherence to COVID-19 vaccina…
Global epidemiology of coronavirus disease 2019 and lessons for effective control of this and future pandemics
2021
Barely 1 year after severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) was first reported in China, the virus has infected approximately 120 million people, caused around 3 million deaths, and adversely affected the global economy Despite stringent measures to flatten the epidemiologic curve of the pandemic, there have been spikes and waves of the infection in many countries, particularly in the American, European, and Asian continents This review critically evaluated the global epidemiology of the novel coronavirus disease 2019 (COVID-19) to provide advice on other possible ways of managing the disease as various COVID-19 vaccines are being rolled out To effectively control this …
Structure‐ and Interaction‐Based Design of Anti‐SARS‐CoV‐2 Aptamers
2022
Aptamer selection against novel infections is a complicated and time-consuming approach. Synergy can be achieved by using computational methods together with experimental procedures. This study aims to develop a reliable methodology for a rational aptamer in silico et vitro design. The new approach combines multiple steps: (1) Molecular design, based on screening in a DNA aptamer library and directed mutagenesis to fit the protein tertiary structure; (2) 3D molecular modeling of the target; (3) Molecular docking of an aptamer with the protein; (4) Molecular dynamics (MD) simulations of the complexes; (5) Quantum-mechanical (QM) evaluation of the interactions between aptamer and target with …
Wpływ rozwiązań prawnych uchwalonych w dobie pandemii SARS-CoV-2 na instytucję dozoru elektronicznego
2021
Dozór elektroniczny stanowi bez wątpienia novum w polskim systemie prawa karnego. Stosowanie tejże instytucji stało się możliwe dzięki wejściu w życie ustawy z dnia 7 września 2007 r. o wykonywaniu kary pozbawienia wolności poza zakładem karnym w systemie dozoru elektronicznego. Dalsza dynamiczna ewolucja elektronicznego monitoringu nastąpiła wskutek kluczowych reform prawa karnego, jakie w szczególności przeprowadzono w latach 2015-2018. Jednakże nie bez znaczenia pozostaje okoliczność, że pewne nadzwyczajne, a zarazem kompleksowe unormowania przewidziano również w związku z wprowadzonym w dniu 20 marca 2020 r. stanem epidemii, co znalazło wyraz m.in. w ustawie z dnia 31 marca 2020 r. o zm…
Levels and Changes of Physical Activity in Adolescents during the COVID-19 Pandemic: Contextualizing Urban vs. Rural Living Environment
2020
The COVID-19 pandemic and the social distancing implemented shortly after influence physical activity levels (PALs). The purpose of this investigation was to evaluate the changes in PAL and factors associated with PALs among Croatian adolescents while considering the impact of community (urban vs. rural living environment). The sample included 823 adolescents (mean age: 16.5 ±
Reinforcement learning in a multi-agent framework for pedestrian simulation
2014
El objetivo de la tesis consiste en la utilización de Aprendizaje por refuerzo (Reinforcement Learning) para generar simulaciones plausibles de peatones en diferentes entornos. Metodología Se ha desarrollado un marco de trabajo multi-agente donde cada agente virtual que aprende un comportamiento de navegación por interacción con el mundo virtual en el que se encuentra junto con el resto de agentes. El mundo virtual es simulado con un motor físico (ODE) que está calibrado con parámetros de peatones humanos extraídos de la bibliografía de la materia. El marco de trabajo es flexible y permite utilizar diferentes algoritmos de aprendizaje (en concreto Q-Learning y Sarsa(lambda) en combinación c…
Antioxidant Effects of Dietary Supplements on Adult COVID-19 Patients: Why Do We Not Also Use Them in Children?
2022
Respiratory tract infections (RTIs) are very common in children, especially in the first five years of life, and several viruses, such as the influenza virus, Respiratory Syncytial Virus, and Rhinovirus, are triggers for symptoms that usually affect the upper airways. It has been known that during respiratory viral infections, a condition of oxidative stress (OS) occurs, and many studies have suggested the potential use of antioxidants as complementary components in prophylaxis and/or therapy of respiratory viral infections. Preliminary data have demonstrated that antioxidants may also interfere with the new coronavirus 2’s entry and replication in human cells, and that they have a role in …
Reply to: Kow CS et al. Are severe asthma patients at higher risk of developing severe outcomes from COVID-19?
2021
Pre-sleep arousal and sleep quality during the COVID-19 lockdown in Italy
2021
Abstract Objective The COVID-19 pandemic has strongly affected daily habits and psychological wellbeing, and many studies point to large modifications in several sleep and sleep-related domains. Nevertheless, pre-sleep arousal during the pandemic has been substantially overlooked. Since hyperarousal represents one of the main factors for the development and the perpetuation of chronic insomnia disorder, the assessment of variables associated with high levels of pre-sleep arousal during the pandemic is clinically relevant. The study aimed to assess the prevalence and predictors of perceived sleep quality and pre-sleep arousal in an Italian sample during the COVID-19 lockdown. Methods We used…