Search results for " SIT"

Synthesis and Structure-Affinity Relationships of Spirocyclic Benzopyrans with Exocyclic Amino Moiety

2019

σ1 and/or σ2 receptors play a crucial role in pathological conditions such as pain, neurodegenerative disorders, and cancer. A set of spirocyclic cyclohexanes with diverse O-heterocycles and amino moieties (general structure III) was prepared and pharmacologically evaluated. In structure-activity relationships studies, the σ1 receptor affinity and σ1:σ2 selectivity were correlated with the stereochemistry, the kind and substitution pattern of the O-heterocycle, and the substituents at the exocyclic amino moiety. cis-configured 2-benzopyran cis-11b bearing a methoxy group and a tertiary cyclohexylmethylamino moiety showed the highest σ1 affinity ( Ki = 1.9 nM) of this series of compounds. In…

Use of driving simulators for advanced driver assistance Systems evaluation in emergency situations

2012

Introducing advanced driver assistance systems in cars has numerous consequences, particularly on drivers' behavior and their interaction with the vehicle. The expected safety benefits of assistance systems can thus be jeopardized. In order to assess the actual safety benefits, driving simulators offer a safe and cheap alternative. This doctoral work relies on experiments carried out on driving simulators with different assistance systems. A first experimental part focuses on longitudinal control assistance: we studied drivers' familiarization with a Forward Collision Warning system in critical situations. A second experimental part focuses on lateral control assistance: we studied drivers'…

Język polski - ojczysty nieobcy czy obcy? Wyzwania edukacji językowej w czasach ponowoczesnych

2016

W artykule podjęty został temat rangi szkolnego nauczania języka polskiego jako ojczystego na tle uczenia języków obcych. Stwierdzono, że nie tylko w polityce językowo-edukacyjnej państwa polskiego, ale także w przekonaniach społecznych i działaniach uczelni wyższych widoczne jest preferowanie języków obcych i niedoszacowanie potrzeb rozwijania kompetencji językowej i komunikacyjnej w zakresie języka polskiego. Niewielka też jest społeczna świadomość znaczenia dobrego władania językiem ojczystym. O konieczności doszacowania wagi rozwijania i doskonalenia sprawności językowo-komunikacyjnych w języku ojczystym świadczą zmiany kulturowe dokonujące się we współczesnym świecie, które obniżają po…

Sui passi della comunità: attaccamento al luogo e identità di luogo come fattori di protezione del sé

2009

Riconfigurare i territori metroplitani. Forme di urbanizzazione e fenomeni di pressione insediativa sui sistemi di interesse naturale in Sicilia

2018

The consumption of the soil due to urbanization it is a phenomena already for many years under observations, but of which only the scientific environment has noticed the elevated environmental impact progress. From a disciplinary point of view, is possible to identify a line of research focusing on the analysis and identification of new morphologies of urbanization and on the interaction among different settlement patterns coexisting in a specific context. This reading complements with the scientific production about the forms of settlement pressure on environmental systems, producing change and deterioration on natural ecosystems and loss of biodiversity. A necessary reference for this lin…

It’s Not Only What You Say, But How You Say It : Investigating the Potential of Prosodic Analysis as a Method to Study Teacher’s Talk

2018

In this study, we introduce new insights into prosodic analyses as an emerging method to study what happens in classrooms interactions. We claim that the prosodic aspects (features of speech such as intonation, volume and pace) of talk are important, but under-represented in the learning sciences. These prosodic aspects may be used to complement, intensify or even reverse the linguistic content of speech. Thus far, most research on classrooms has focused on the content (what is said) rather than on understanding the meaning of the prosodic features (how it is said) of talk. In this study, we introduce prosodic analyses as a method to study classroom discussions. Our exploratory experiment f…

Influence of “relation with learning” on a situation of communication teaching-learning for different Scholar pupils

2015

International audience; Communication can be understood as the set of relations between two people interacting. Between learners and teachers, the relationship is induced by a situation of communication teaching-learning. In this constructivism theory, Chevallard and Charlot [1,2] make the hypotesis that learning requires a factor commonly underestimated: the “relation with learning”. This study surveys the impact of the “relation with learning” of pupils under a situation of communication teaching-learning. The evolution of conceptions among learners had been studied in parallel of pedagogical method proposed by teacher.The necessity to change the conceptions in scientific learning is clai…

Vegetation dynamics on abandoned terraces of Sicily: the course and driving forces of succession

2007

In Mediterranean Europe, terrace landscapes can be found where 1) the orography is characterized by hills or mountains, 2) there is a high amount of stone outcrops and 3) the human need for agricultural production was quite high till the recent past. During the last century, many of these landscapes have been abandoned, due to their unsuitability for mechanized, intensive agriculture and due to the general land abandonment trend which arised in large parts of Europe. Since with land abandonment start secondary succession processes, the plant and animal communities linked to agroecosystems are replaced by other species which find their habitat in the developing succession stages. This proces…

La aplicación del derecho extranjero en iberoamérica y la unión europea: : paralelismos desde la diferencia

2021

The potential application of a foreign law constitutes the logical outcome of any Private International Law? system. However, and despite its relevance, this issue lacks a common answer in the EU. In contrast to this, the analysis of the solutions drafted in Latin America as regards this issue grants a novel dimension to the European situation on this issue as well as highlights a meritorious reality that shows a high and very relevant degree of harmonization

E-Sports y brecha de género: la percepción de las profesionales españolas

2019

The present paper aims to identify the causes of under-representation of women in E-sports. According to a genre perspective, interest in videogames at the amateur level is quite similar. However, in its professional level, female participation becomes very limited. The fact that physical effort is irrelevant (a requirement for ?traditional sports?) could be considered a variable that would negatively affect greater to equality in the conditions of access and participation of women in electronic sports. Against any predictions, the data on the presence of women are elocuent: few women, with much lower wages than men to remunerate same skills, and a general complaint by the female profession…