Search results for " SLE"
showing 10 items of 597 documents
Hair Cortisol Concentration as a Biomarker of Sleep Quality and Related Disorders
2021
Cortisol is the end product of the hypothalamic-pituitary-adrenal (HPA) axis, and its production is increased mainly in stressful situations or in chronic disorders accompanied by stress enhancement. Altered cortisol concentrations have been reported in a number of neuropsychiatric diseases and sleep disorders. Cortisol concentrations have been measured using several methods, and in several matrixes, such as blood, saliva, and urine. However, lately, hair cortisol, for several reasons, has emerged as a promising biomarker of long-term retrospective HPA activation. Several experimental approaches for cortisol measurement with the corresponding concentration reference ranges and a summary of …
Erenumab and Possible CGRP Effect on Chronotype in Chronic Migraine: A Real-Life Study of 12 Months Treatment
2023
The introduction of monoclonal antibodies (mAbs) directed against the calcitonin gene-related peptide (CGRP), or its receptor (CGRPr), revolutionized migraine management due to their high efficacy and few side effects. Data suggest that the CGRP may even be implicated in circadian rhythm, but studies about the effect of anti-CGRP treatments on sleep are still lacking. The aim of the present study was to assess the effect of erenumab (70 and 140 mg per month), a human mAb directed against CGRPr, on chronotype in chronic migraineurs; secondly, we assessed its efficacy, safety, and the effects on anxiety and depression. Sleep was evaluated using self-administrable questionnaires investigating …
Modèle des voies réflexes et cérébelleuses, permettant le calcul de fonctions inverses et la commande d'un segment mécanique mobile
2004
14/07/2004; La commande et le contrôle des mouvements des membres par les voies cérébelleuses et réflexes sont modélisées au moyen d'un circuit dont la structure est déduite de contraintes fonctionnelles. 1/ La première contrainte est que les mouvements rapides des membres doivent être précis, quoiqu'ils ne puissent pas être commandés en boucle fermée au moyen de signaux sensoriels. Les voies qui préparent les ordres moteurs doivent donc contenir des fonctions inverses approximées des fonctions biomécaniques du membre et des muscles. Or une telle fonction peut être calculée au moyen de boucles de rétroaction parallèles, dont la structure est comparable à l'anatomie des voies cérébelleuses. …
Burden of Comorbidities in Patients with OSAS and COPD-OSAS Overlap Syndrome
2021
Background and Objectives: Obstructive sleep apnea syndrome (OSAS) and chronic obstructive pulmonary disease (COPD) are usually associated with multi-morbidity. The aim of this study was to retrospectively investigate the prevalence of comorbidities in a cohort of patients with OSAS and COPD-OSAS overlap syndrome (OS) patients and to explore differences between these two groups. Materials and Methods: Included were consecutive OS patients and OSAS patients who had been referred to our sleep laboratory, and were matched in terms of sex, age, BMI, and smoking history. Presence of comorbidities was recorded based on their medical history and after clinical and laboratory examination. Results: …
Sporadic and Familial Variants in NF1: An Explanation of the Wide Variability in Neurocognitive Phenotype?
2020
Background: Cognitive impairment is the most common neurological manifestation in NF1 and occurs in 30-70% of NF1 cases. The onset and severity of each specific cognitive deficit varies greatly from child to child, with no apparent external causes. The wide variability of phenotype is the most complex aspect in terms of management and care. Despite multiple research, the mechanism underlying the high heterogeneity in NF1 has not yet been elucidated. While many studies have focused on the effects of specific and precise genetic mutations on the NF1 phenotype, little has been done on the impact of NF1 transmission (sporadic vs. familial cases). We used a complete neuropsychological evaluation…
Darbības vārdu konotāciju analīze Lielbritānijas laikrakstu redaktoru slejās
2019
Vārda nozīme ir sarežģīts un daudzpusīgs termins, tādēļ tam ir denotatīva (tieša) kā arī konotatīva (asociatīva) nozīme, kas paskaidro asociācijas, emocijas un individuālu pieredzi. Šī pētījuma mērķis ir pētīt darbības vārdu konotatīvās nozīmes britu laikrakstu redaktoru slejās, kā arī to funckijas un pielietojumu. Šajā pētījumā izmantotās metodes: pētīt teorijas materiālus un izveidot struktūru pētījuma analīzei, noformēt redaktoru sleju korpusu teskta analīzei, kurā iekļautas atrasto darbības vārdu konotatīvās nozīmes un semantiskie lauki. Analīzei tike izvēlēti raksti no The Independent. The Guardian un The Herald, kur aplūkota breksita tēma. BBC News raksti par breksitu tika izvēlēti, l…
Le pratiche commerciali sleali
2008
La direttivasulle pratiche commerciali sleali. Tra tutela del consumatore e disciplina della concorrenza.
2008
Il lavoro analizza la direttiva comunitaria in materia di pratiche commerciali scorrette ed il provvedimento normativo di attuazione emanato dal legislatore italiano, anche attraverso uno studio critico di alcune scelte di politica legislativa effettuate in tema di tutela della concorrenza e dei consumatori.
Respuesta cardiovascular al estrés en pacientes con epilepsia farmacorresistente: datos preliminares
2021
El estrés es un factor de riesgo para las enfermedades cardiovasculares en la población general. La epilepsia se ha considerado un modelo adecuado de estrés crónico, con mayor incidencia de mortalidad cardiovascular que la población general. Este estudio proporciona datos preliminares sobre la respuesta cardiovascular ante un estresor cognitivo y una evaluación neuropsicológica en pacientes con epilepsia, explorando las relaciones entre la respuesta cardiovascular y el rendimiento cognitivo dependiendo del hemisferio responsable de la epilepsia. Treinta y cinco pacientes con epilepsia farmacorresistente, 17 con el área epileptógena(AE) en el hemisferio izquierdo (LH) y 18 con AE en el hemis…