Search results for " SOD"
showing 10 items of 271 documents
The Sea Urchin sns Insulator Blocks CMV Enhancer following Integration in Human Cells
2001
Insulators are a new class of genetic elements that attenuate enhancer function directionally. Previously, we characterized in sea urchin a 265-bp-long insulator, termed sns. To test insulator activity following stable integration in human cells, we placed sns between the CMV enhancer and a tk promoter up-stream of a GFP transgene of plasmid or retroviral vectors. In contrast to controls, cells transfected or transduced with insulated constructs displayed a barely detectable fluorescence. Southern blot and PCR ruled out vector rearrangement following integration into host DNA; RNase protection confirmed the enhancer blocking activity. Finally, we demonstrate that two cis-acting sequences, p…
Il desiderio di capire. Processi e attività di costruzione di significati
2009
Il contributo discute gli aspetti più significativi che emergono dalla produzione scritta di studenti, in riferimento a quattro esercizi di Decision Making. Il lavoro di analisi e valutazione degli elaborati scritti, codificati in rapporto alle abilità metacognitive che si intendeva potenziare, è stato realizzato in base a 20 indicatori scelti e costruiti dal gruppo di ricerca.
Progresīvās brīvības atņemšanas soda izpildes sistēmas īstenošana ieslodzījuma vietās
2022
Latvijas Universitātes studentes Agneses Kairišas bakalaura darbs “Progresīvās brīvības atņemšanas soda izpildes sistēmas īstenošana ieslodzījumu vietās”. Latvijā brīvības atņemšanas soda izpilde tiek īstenota atbilstoši soda progresīvās izpildes principam. Katrā valstī principa piemērošana atšķiras, līdz ar to, bakalaura darba autore ir izvirzījusi mērķi izpētīt progresīvās brīvības atņemšanas sodu sistēmas īstenošanu Latvijā, sistēmas efektivitāti un atbilstību starptautiskajām prasībām. Mērķa sasniegšanai tika izpētīts brīvības atņemšanas soda izpildes jēdziens, vēstures attīstība un ieslodzījumu vietas. Analizēta progresīvas brīvības atņemšanas soda izpildes īstenošana slēgtajos, daļēji…
Administratīvās atbildības piemērošanas problēmas nepilngadīgajiem
2021
Darba mērķis ir identificēt ar nepilngadīgo administratīvo atbildību saistītās juridiskās problēmas Latvijā, sniegt tām risinājumu. Noskaidrot efektivitāti nepilngadīgo administratīvās atbildības piemērošanā, pie pašreizējā tiesiskā noregulējuma. Bakalaura darba mērķis ir: •izpētīt procesuālās kārtības problemātiku, piemērojot administratīvo atbildību nepilngadīgajiem; •noskaidrot tiesību normu piemērotāja pamatojumus, izvērtējot audzinoša rakstura piespiedu līdzekļu piemērošanas lietderīgumu; •noskaidrot administratīvā soda – naudas soda un audzinoša rakstura piespiedu līdzekļu efektivitāti. Gala rezultātā tika konstatēts, ka pie esošā normatīvā akta regulējuma attiecībā uz procesuālo kārt…
Where Cyber Meets the Electromagnetic Spectrum
2019
Cyber linked with Information Technology, computers and the internet are the most commonly understood potential threats that everybody is aware of nowadays. In the case of National Cyber Strategy most efforts are given to these potential battlefields and threats. But is it enough to stay with these paradigms? Cyber warfare will look for utmost effects for chaos and misalignment of economy and therefore we cannot exclude the facts, that there is a potential threat also possible in the cut volumes between the information technology, the electromagnetic spectrum and its linked infrastructure and processes. We understand the technology for mobile telecommunications and data transfer, as the pro…
Brīvības atņemšanas piemērošana nepilngadīgajiem
2019
Bakalaura darba temats „Brīvības atņemšanas piemērošana nepilngadīgajiem” ir aktuāls, jo nepilngadīgo noziedzība ir pastāvējusi vienmēr un rada problēmas un satraukumu sabiedrībā, jo nepilngadīgie ir mūsu sabiedrības nākotne. Brīvības atņemšanas sods ir smagākais, ko ir iespējams piemērot, tomēr to piemēro tikai galējos gadījumos, kad citi soda veidi nav efektīvi un nesniegtu Krimināllikumā noteiktā soda mērķa realizāciju. Kā arī nepilngadīgajiem ir nepieciešama cita pieeja kā pilngadīgajiem, jo šīs personas ir vēl attīstības stadijā. Darba mērķis ir izpētīt brīvības atņemšanas piemērošanas nepilngadīgajiem vēsturisko attīstību Latvijā, izvērtēt, kādos apstākļos Latvijā ir piemērojama brīvī…
Impact of Glucose-Lowering Medications on Cardiovascular and Metabolic Risk in Type 2 Diabetes
2020
Type 2 Diabetes Mellitus (T2DM) is associated with a high risk of atherosclerotic cardiovascular (CV) disease. Among the well-known pathophysiologic factors, crucial roles are played by endothelial dysfunction (caused by oxidative stress and inflammation hyperglycemia-linked), increased activity of nuclear factor kB, altered macrophage polarization, and reduced synthesis of resident endothelial progenitor cells. As consequence, a potentially rapid progression of the atherosclerotic disease with a higher propensity to unstable plaque is arguable, finally leading to significantly increased cardiovascular mortality. Main managements are focused on both prevention and early diagnosis, by target…
Salt and fat contents in model cheeses influence the release of sodium ions and aroma compounds
2012
The health authorities recommend a reduction in salt (NaCl) and fat contents of foodstuff. But reducing such components without affecting acceptability is a major challenge, particularly because of the interactions with other ingredients, such as aroma compounds. One way could be to increase the mobility of both sodium ions and aroma compounds in food matrix and their release during consumption. This study consists in a multimodal approach to understand the effect of changes in composition of model cheeses on the mobility and release of flavour molecules (NaCl, aroma compounds). Six flavoured model cheeses have been formulated (three fat/protein contents, two NaCl contents). The rheological…
5-Substituted 4,5-Dihydro-1,2,4-triazin-3(2H)-ones from the Unprecedented Reaction between α-N-Protected Amino Acid Hydrazides and NaBH4
2006
α-N-Protected amino acid hydrazides (1) readily reacted with NaBH4 to afford 5-substituted 4,5-dihydro-1,2,4-triazin-3(2H)-one derivatives 2 in good yields. Unfortunately, the reaction caused partial racemization at the α-amino acidic carbon atom of the starting hydrazide. A mechanism, supported by experimental evidence, has been proposed in an attempt to explain this to date unprecedented reaction. The structure of compounds 2 was confirmed by X-ray structural analysis. (© Wiley-VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2006)
NonclassicalPschorr andSandmeyer Reactions in Pyrazole Series
2005
The diazonium salt derived from 4-amino-N,1,3-trimethyl-N-(3-methyl-1-phenyl-1H-pyrazol-5-yl)-1H-pyrazole-5-carboxamide (14) was reacted with a mixture of CuSO4 and NaCl, with ascorbic acid as an initiator to afford the planar derivative 4,6-dihydro-1,4,6,8-tetramethyl-3-phenyldipyrazolo[3,4-b:4′,3′-d]pyridin-5(3H)-one (16) and its unexpected isomer 4,6-dihydro-3,4,6,8-tetramethyl-1-phenyldipyrazolo[4,3-b:4′,3′-d]pyridin-5(1H)-one (17), as well as the epimers (3S,4S)- (or (3S,4R)-) and (3S,4R)- (or (3S,4S)-) 4-chloro-2,4-dihydro-1′,3′,5,5′-tetramethyl-2-phenylspiro[pyrazole-3,4′(1′H)-pyrrolo[3,4-c]pyrazol]-6′(5′H)-one (18a and b, respectively). Epimers 18a and b were converted under basic c…