Search results for " STEM"

Molecular characterization of cancer stem cells in anaplastic thyroid carcinoma

2009

Funkcionālo un radioloģisko rezultātu salīdzinājums pacientiem pēc pleca locītavas endoprotezēšanas ar Global Icon™ Stemless un Global Unite® anatomi…

2021

Darba aktualitāte: Pleca locītavas endoprotezēšana ir viena no ķirurģiskās ārstēšanas metodēm osteoartrīta slimībai. Mūsdienu tehnoloģiskās iespējas nodrošina endoprotēžu attīstību un daudzveidību. Aizstājot pacienta dabīgo locītavu ar mākslīgo implantu, svarīgi ir izvēlēties viņa stāvoklim, ikdienas aktivitātēm un prasībām atbilstošāko protēzes veidu, lai sasniegtu labāko pēcoperācijas rezultātu. Darba mērķis: Salīdzināt Global Icon anatomiskās bezkājiņas implanta efektivitāti ar Global Unite implanta ar kājiņu efektivitāti, izvērtējot klīniskos un radioloģiskos rezultātus gadu pēc operācijas. Darba uzdevumi: Veikt CMS rezultātu analīzi pirms operācijas un gadu pēc endoprotezēšanas operāci…

Successful subretinal delivery and monitoring of MicroBeads in mice

2013

BACKGROUND: To monitor viability of implanted genetically engineered and microencapsulated human stem cells (MicroBeads) in the mouse eye, and to study the impact of the beads and/or xenogenic cells on retinal integrity. METHODOLOGY/PRINCIPAL FINDINGS: MicroBeads were implanted into the subretinal space of SV126 wild type mice using an ab externo approach. Viability of microencapsulated cells was monitored by noninvasive retinal imaging (Spectralis™ HRA+OCT). Retinal integrity was also assessed with retinal imaging and upon the end of the study by light and electron microscopy. The implanted GFP-marked cells encapsulated in subretinal MicroBeads remained viable over a period of up to 4 mont…

Higher oxidative stress in human dental pulp stem cells cultured at 21% O2 compared to 5% O2

2012

Impact of anemia on long term prognosis of patients with STEMI treated with PCI and dual antiplatelet therapy

2016

Anemia on admission and Hb drop % are associated with worse long term prognosis and they are independent risk factor for adverse events in patient with STEMI treated with PCI and dual antiplatelet therapy.

Stimulation of Wound Revascularization by Adenosine Receptor Activation

2010

Adenosine is an endogenous mediator implicated in wound healing. The exact mechanisms and receptors involved are still under evaluation. We have observed that topical application of a selective adenosine A2A receptor agonist promotes wound healing in experimental animals, both healthy and with impaired healing. Histological analysis revealed that adenosine promoted granulation tissue formation, with increased cellularity, matrix deposition, and vessel density. Adenosine may exert effects on many different cell types that finally result in promotion of angiogenesis and, furthermore, homing of endothelial precursor cells into sites of injury. We will review the effect of adenosine receptor ac…

Facilitated Anion Transport Induces Hyperpolarization of the Cell Membrane That Triggers Differentiation and Cell Death in Cancer Stem Cells

2015

Facilitated anion transport potentially represents a powerful tool to modulate various cellular functions. However, research into the biological effects of small molecule anionophores is still at an early stage. Here we have used two potent anionophore molecules inspired in the structure of marine metabolites tambjamines to gain insight into the effect induced by these compounds at the cellular level. We show how active anionophores, capable of facilitating the transmembrane transport of chloride and bicarbonate in model phospholipid liposomes, induce acidification of the cytosol and hyperpolarization of plasma cell membranes. We demonstrate how this combined effect can be used against canc…

Itraconazole versus Fluconazole for Antifungal Prophylaxis

2004

Embryonic neural cell adhesion molecules on human natural killer cells

1989

The neural cell adhesion molecules (NCAM) are surface glycoproteins that were first described in brain tissue. NCAM mediate adhesion in a variety of cell-cell interactions. In the present study we show that the so-called "embryonic" NCAM, i.e., the highly polysialylated forms of these proteins, are expressed on natural killer cells and some CD3+ cells in man. Homotypic binding of NCAM, believed to be of importance for cell-cell adhesion in neural tissues, appears not to be essential for NK cell-mediated killing. Yet, NCAM might be involved in NK cell migration, homing or related functions.

Depletion of alloreactive T cells via CD69: implications on antiviral, antileukemic and immunoregulatory T lymphocytes

2005

Selective depletion of alloreactive T cells from stem-cell allografts should abrogate graft-versus-host disease while preserving beneficial T cell specificities to facilitate engraftment and immune reconstitution. We therefore explored a refined immunomagnetic separation strategy to effectively deplete alloreactive donor lymphocytes expressing the activation antigen CD69 upon stimulation, and examined the retainment of antiviral, antileukemic, and immunoregulatory T cells. In addition to the CD69high T cell fraction, our studies retrieved two T cell subsets based on residual CD69 expression. Whereas, truly CD69(neg) cells were devoid of detectable alloresponses to original stimulators, CD69…