Search results for " STRESS"
showing 10 items of 3936 documents
DNA Photodamage and Repair: Computational Photobiology in Action
2020
DNA is constantly exposed to external and metabolic stress agents, including the solar radiation and in particular the UV portion of the electromagnetic spectrum. Such source of stress can induce photochemical modification of the structure of DNA and of its basic components, i.e. the nucleobases. DNA lesions may ultimately lead to genomic instability, mutations, and even to carcinogenesis. Hence, cells dispose of complex biochemical repair pathways in charge of remove the DNA lesions and avoid their accumulation. In this Chapter, we present the complexity of the DNA lesion chemical and structural space, also complicated by the intricate coupling with the biological relevant signaling pathwa…
Deficiency of the Cockayne syndrome B (CSB) gene aggravates the genomic instability caused by endogenous oxidative DNA base damage in mice.
2007
The Cockayne syndrome B protein (CSB) has long been known to be involved in the repair of DNA modifications that block the RNA polymerase in transcribed DNA sequences (transcription-coupled repair). Recent evidence suggests that it also has a more general role in the repair of oxidative DNA base modifications such as 7,8-dihydro-8-oxo-2'-deoxyguanosine (8-oxoG). In mammalian cells, 8-oxoG is a substrate of the repair glycosylase OGG1. Mice without this enzyme accumulate 8-oxoG in the genome and have elevated spontaneous mutation rates. To elucidate the role of CSB in the prevention of mutations by oxidative DNA base damage, we have generated mice that are deficient in Csb or Ogg1 or both ge…
Redox regulation of genome stability by effects on gene expression, epigenetic pathways and DNA damage/repair
2015
Reactive oxygen and nitrogen species (e.g. H2O2, nitric oxide) confer redox regulation of essential cellular signaling pathways such as cell differentiation, proliferation, migration and apoptosis. In addition, classical regulation of gene expression or activity, including gene transcription to RNA followed by translation to the protein level, by transcription factors (e.g. NF-κB, HIF-1α) and mRNA binding proteins (e.g. GAPDH, HuR) is subject to redox regulation. This review will give an update of recent discoveries in this field, and specifically highlight the impact of reactive oxygen and nitrogen species on DNA repair systems that contribute to genomic stability. Emphasis will be placed …
The Role of Ancestral Duplicated Genes in Adaptation to Growth on Lactate, a Non-Fermentable Carbon Source for the Yeast Saccharomyces cerevisiae
2021
This article belongs to the Section Molecular Informatics.
Diagnosis of sublethal stress in the marine sponge Geodia cydonium: application of the 70 kDa heat-shock protein and a novel biomarker, the Rab GDP d…
1997
Abstract Sponges (Porifera) are among the major phyla inhabiting the marine hard-substrate benthos, both in respect to the number of species and their biomass. Hence reliable biomarkers need to be developed to monitor the environmental load in those animals. Recently, the cDNA for the heat shock protein HSP70 has been isolated from the sponge Geodia cydonium and found to be a reliable indicator for temperature stress. In the present study, we have isolated the Rab GDP-dissociation inhibitor (GDI), which has previously been shown to be a key element in the intracellular traffic system. The 1521 bp long cDNA, encoding sponge GDI, has been isolated and analyzed. The deduced aa sequence ( M r =…
Croissance et miniaturisation de quelques Hildoceras (Cephalopoda) en liaison avec des environnements contraignants de la Téthys toarcienne
1993
Resume La zone a Bifrons (Toarcien moyen) est une perode bien etudiee du point de vue stratigraphique tant en Europe occidentale (marge NW de la Tethys et plates-formes adjacentes) qu'en Italie et Afrique du Nord (marge sud de la Tethys). Dans ces regions, la succession zonale est basee sur l'evolution des Hildoceras. Cependant, on remarque que certains d'entre eux, quelle que soit leur place dans la lignee, presentent des particularites ornementales et dimensionnelles, manifestement liees au gisement dont ils sont, issus et aux conditions qui y regnaient. C'est particulierement le cas des sites d'Italie centrale et d'Algerie situes dans les fonds des ombilics de sedimentation crees par la …
Monoclinic model shear zones
1998
Abstract Although many ductile shear zones are supposed to have developed by approximately simple shear flow, some must have formed under different conditions. A few types of such ‘non-simple shear zones’ have been proposed in the literature such as transpression-, transtension- and stretching-shear zones. This paper presents a full three-dimensional kinematic model of shear zones with monoclinic flow geometry. Monoclinic shear zone types can be classified according to flow parameters, and according to the geometry and orientation of accumulating finite strain. Modelling of finite strain accumulation shows that a number of unusual and potentially problematic structural features may develop …
The Impact of Psychosocial Safety Climate on Health Impairment and Motivation Pathways: A Diary Study on Illegitimate Tasks, Appreciation, Worries, a…
2019
Psychosocial Safety Climate (PSC) describes an organisation’s policies, practices, and procedures that aim at protecting employees’ psychological health and safety. In line with the job demands-resources (JD-R) model, we proposed PSC to be a cause of the causes, that is, an upstream organisational resource that decreases perceived demands and increases perceived resources in the form of illegitimate tasks and appreciation. In turn, this should lead to reduced work-related worries and enhanced work engagement. Based on a diary study across six weeks and a sample of N = 354 nurses, results from multilevel analyses were largely in line with our propositions: On the within level, worries and wo…
Perceived stress in relation to quality of life and resilience in patients with advanced chronic kidney disease undergoing hemodialysis
2021
Background: Patients with chronic kidney disease undergo various stages of therapeutic adaptation which involve lifestyle modifications, physical changes, and adjustment to renal replacement therapy. This process produces adaptive stress. Objective: To identify how resilience, health- related quality of life, and sociodemographic, clinical, and hemodialysis routine-related variables are related to perceived stress in patients with chronic kidney disease receiving hemodialysis for more than six months. Methods: This was a multicenter and cross-sectional study involving 144 patients from the Valencian Community (Spain). The assessment scales used for the study were the Perceived Stress Scale …
Occupational stress among Brazilian oral-maxillofacial surgeons
2009
Purpose: The aim of the present study was to assess the stress level of oral-maxillofacial surgeons, based on the Demand-Control Model. Methods: A cross-sectional study was carried out with 128 oral-maxillofacial surgeons who participated in the Brazilian Congress of Oral-Maxillofacial Surgery held in the city of Florianópolis, State of Santa Catarina, Brazil. Data was obtained using a questionnaire that incorporated the Demand-Control Model (Job Content Questionnaire), which evaluates psychosocial experiences at work. Information on age, gender and professional qualification was also collected. The data was displayed in contingency tables. The following statistical tests were used with a 5…