Search results for " STRESS"

SUCCESSFUL AGING: QUALITY AND QUANTITY

2010

OXIDATIVE STRESS AND ALZHEIMER’S DISEASE

2012

Introduction: Brain tissue is particularly susceptible to oxidative damage, which has been associated with pathological findings of Alzheimer’s disease (AD), such as amyloid plaques and protein fibrils. Oxidative stress alterations, including increased production of reactive oxygen metabolites, decline of antioxidant systems, and decreased efficiency in repairing damaged molecules, have been linked to the development of AD. Postmortem studies on brain tissue from AD patients have shown several oxidative damage markers, such as increased lipid peroxidation, oxidative damage of proteins, glyco-oxidation, and reduction of antioxidant enzyme systems. Methods: We studied 40 patients referred to …

Nutritional prevention of cognitive decline and dementia.

2018

Cognitive impairment results from a complex interplay of many factors. The most important independent predictor of cognitive decline is age but other contributing factors include demographic, genetic, socio-economic, and environmental parameters, including nutrition. The number of persons with cognitive decline and dementia will increase in the next decades in parallel with aging of the world population. Effective pharmaceutical treatments for age-related cognitive decline are lacking, emphasizing the importance of prevention strategies. There is extensive evidence supporting a relationship between diet and cognitive functions. Thus, nutritional approaches to prevent or slow cognitive decli…

MAGNESIUM HOMEOSTASIS AND AGING

2009

aGING IS VERY OFTEN ASSOCIATED WITH MAGNESIUM (mG) DEFICIT.tOTAL PLASMA MAGNESIUM CONCENTRATIONS ARE REMARKABLY CONSTANT IN HEALTHY SUBJECTS THROUGHOUT LIFE

Magnesium Role in Health and Longevity Final

2018

Reduced Magnesium (Mg intake) is a frequent cause of Mg deficit with age. A decreased intestinal Mg absorption and an increased Mg loss may also contribute, as well as the use of medicaments. Mg requirements may be higher with aging. Alterations of Mg metabolism with age, cellular Mg transport systems and problems with measurement methods are discussed. Mg contained in water is more bio-available than Mg in food and it is a possible alternative to Mg supplementation in the correction of Mg deficiencies. Mild to moderate Mg deficits are generally asymptomatic and clinical signs are usually absent or non-specific. Hyperemotionality, tremor, asthenia, sleep disorders, and amnesic and cognitive…

Pathogenetic Mechanisms of Hypertension-Brain-Induced Complications: Focus on Molecular Mediators.

2021

There is growing evidence that hypertension is the most important vascular risk factor for the development and progression of cardiovascular and cerebrovascular diseases. The brain is an early target of hypertension-induced organ damage and may manifest as stroke, subclinical cerebrovascular abnormalities and cognitive decline. The pathophysiological mechanisms of these harmful effects remain to be completely clarified. Hypertension is well known to alter the structure and function of cerebral blood vessels not only through its haemodynamics effects but also for its relationships with endothelial dysfunction, oxidative stress and inflammation. In the last several years, new possible mechani…

Antiaging Medicine

2009

• The factors best demonstrated to delay aging are fruit and vegetables, exercise, not smoking, drinking one or two glasses of alcohol daily, and fish consumption. • Vitamin D replacement, in persons with low 25[OH] vitamin D levels, decreases hip fractures, improves muscle strength, enhances function, and decreases mortality. • Antiaging medicine has been hijacked by charlatans who promote unproven or dangerous remedies to a naïve aging public. • Too often animal studies that produce longevity are directly applied to humans before appropriate clinical trials have been carried out. • There is no evidence that hormones or megadoses of vitamins prolong life. • Numerous products of varying qua…

Cien años de... ¡salud, dieta mediterránea y longevidad: el papel del aceite de olivas

2006

APPROCCI NUTRIZIONALI NELLA PREVENZIONE DEL DECLINO COGNITIVO E DELLA MALATTIA DI ALZHEIMER

2017

Vi sono consistenti evidenze epidemiologiche a supporto di una stretta relazione tra alimentazione, de-clino cognitivo e malattia di Alzheimer. È ipotizzabile che il rischio di declino cognitivo nell’anziano possa essere ridotto tramite appropriati interventi dietetici, e che l’adozione di una dieta e di uno stile di vita sani possano contribuire a ritardare l’insorgenza del-la malattia di Alzheimer, anche grazie alla potenzia-le azione sulla prevenzione della aterosclerosi. Sono state studiate diverse sostanze nutritive, componenti alimentari, integratori e modelli dietetici in relazione alla loro associazione con la performance cognitiva e con lo sviluppo del declino cognitivo e della dem…

Valutazione in vivo dello stress ossidativo e dell'attivazione piastrinica nell'ipobetalipoproteinemia familiare: confronto con l'ipercolesterolemia …

Background Oxidative stress is associated with an increased risk of atherothrombosis and platelet activation as several animal models have been shown. The increased production of reactive oxygen species (ROS) leads to lipids peroxidation of the cell membranes and of lipoproteins, high production of F2-isoprostanes from arachidonic acid, thus modulating the platelet activation induced by thromboxane. 8-iso-PGF2a and 11-deidro-tromboxane (TX)B2 are in vivo markers of oxidative stress and platelet activation, respectively. Recently it has been shown that subjects with low plasma levels of HDL (increased cardiovascular risk) present with high urinary levels of these markers. This excretion is r…