Search results for " STRESS"

Personības iezīmes un emociju regulācijas grūtības kā uztvertā stresa prognozētājas

2022

Pētījuma mērķis bija noskaidrot kāda saistība pastāv starp uztverto stresu, personības iezīmēm un emociju regulācijas grūtībām, un pārbaudīt cik lielā mērā personības iezīmes un emociju regulācijas grūtības prognozē uztvertā stresa līmeņa rādītājus, kā arī pārbaudīt cik lielā mērā personības iezīmes prognozē emociju regulācijas grūtību kopīgo rādītāju. Pētījumā piedalījās 65 respondenti, 58 sievietes un 7 vīrieši, vecumā no 19 līdz 74 gadiem (M=34,82; SD=31,00). Pētījumā tika izmantotas 3 aptaujas: Lielā piecinieka personības aptauja, Emociju regulācijas grūtību skala un Uztvertā stresa skala. Pētījumā iegūtie rezultāti norāda, ka augstāki neirotisma rādītāji ir statistiski nozīmīgi saistīt…

Emocionālās ēšanas, uztvertā stresa un ēšanas pārliecību saistības sievietēm

2021

Pētījuma mērķis bija noskaidrot, kādas saistības pastāv starp emocionālās ēšanas, ķermeņa masas indeksa (ĶMI), vecuma, uztvertā stresa un ēšanas pārliecību rādītājiem sievietēm. Kā arī noskaidrot, kuri no uztvertā stresa, ēšanas pārliecību dimensijas un ĶMI rādītājiem statistiski nozīmīgi paredz emocionālās ēšanas rādītājus un kuras no ēšanas pārliecībām statistiski nozīmīgi paredz augstāku ĶMI sieviešu izlasē. Pētījumā piedalījās 192 sievietes vecuma grupā no 18 līdz 66 gadiem ar normālu ĶMI (ĶMI ≤ 25). Pētījumā izmantotas Emocionālās ēšanas aptauja (Emotional Eating Scale (EES), Arnow, Kenardy, & Agras, 1995), Uztvertā stresa skala (Perceived Stress Scale (PSS), Cohen, Kamarck, & Mermelst…

Emotional Separation, Parenting Stress, and Adolescents’ Empathic Responsiveness

2011

Emozioni, rischi e stress. Indagini preliminari

2021

Una breve introduzione a una raccolta di saggi su questioni psico-pedagogiche connesse a emozioni, rischi e stress. A brief introduction to a collection of essays on psycho-pedagogical issues related to emotions, risks and stress.

Ensayo clínico multicéntrico, aleatorizado y enmascarado con topiramato versus placebo para el tratamiento de recién nacidos con encefalopatía hipóxi…

2021

Antecedentes: La encefalopatía hipóxico-isquémica (EHI) perinatal constituye una de de las principales causas de muerte o discapacidad a largo plazo en recién nacidos a término en el mundo occidental, afectando a aproximadamente 1-4 por cada 1000 nacidos vivos y, en consecuencia, a alrededor de 5000-20000 recién nacidos por año en Europa. La hipotermia terapéutica se ha convertido en el tratamiento estándar de la EHI moderada o grave, siendo una terapia segura y eficaz para mejorar el desarrollo neurológico tras un insulto hipóxico-isquémico perinatal. A pesar de la hipotermia y las mejoras en los cuidados intensivos neonatales, el 45-50% de los recién nacidos con EHI moderada o grave muere…

2014

Nitric oxide (NO) derived from the endothelial NO synthase (eNOS) has antihypertensive, antithrombotic, anti-atherosclerotic and antiobesogenic properties. Resveratrol is a polyphenol phytoalexin with multiple cardiovascular and metabolic effects. Part of the beneficial effects of resveratrol are mediated by eNOS. Resveratrol stimulates NO production from eNOS by a number of mechanisms, including upregulation of eNOS expression, stimulation of eNOS enzymatic activity and reversal of eNOS uncoupling. In addition, by reducing oxidative stress, resveratrol prevents oxidative NO inactivation by superoxide thereby enhancing NO bioavailability. Molecular pathways underlying these effects of resve…

Sterigmatocystin-induced cytotoxicity via oxidative stress induction in human neuroblastoma cells.

2020

Abstract Sterigmatocystin (STE) is a mycotoxin produced by fungi of the genus Aspergillus. Considering that the effect of STE on neuronal system has not been well studied, the aim of the present study consists to investigate the cytotoxic effects of STE in human neuroblastoma (SH-SY5Y) cells. Moreover, the role of oxidative stress and intracellular defense systems was assessed by evaluating reactive oxygen species (ROS) generation, lipid peroxidation (LPO) and antioxidant no-enzymatic (GSH) levels and enzymatic (GPx, GST, CAT and SOD) activity. Our results revealed that STE decreased cell viability in a dose and time-dependent manner. Furthermore, after 24 h of exposure, STE induced an incr…

Role of quercetin on sterigmatocystin-induced oxidative stress-mediated toxicity.

2021

Oxidative stress appears to be a common trigger for many of the effects associated with the exposure to various mycotoxins, including sterigmatocystin (STE). However, studies to alleviate STE toxicity through the use of natural antioxidants are sparsely reported in literature. In the present study, the cytoprotective effect of quercetin (QUE) was tested in SH-SY5Y cells against STE-induced oxidative stress and cytotoxicity. The MTT assay revealed that STE decreased cell viability, whereas pre-treatment of cells with QUE restored it. The QUE was also found to counteract STE-induced ROS generation and decrease STE-induced up-regulation of the expression of the stress-inducible enzymes HO-1 an…

Sterigmatocystin: Occurrence, toxicity and molecular mechanisms of action – A review

2020

The mycotoxin sterigmatocystin (STE) is produced mainly by Aspergillus fungi. It has been reported to occur in grains and grain-based products, cheese, coffee, spices and beer. The STE is a known biogenic precursor of aflatoxin B1, sharing with it several structural and biological similarities. The STE has been shown to be hepatotoxic and nephrotoxic in animals and it has been classified as possible human carcinogen (group 2B) by IARC. The STE has been reported to cause a marked decrease in cell proliferation in different mammalian cells. Data available on literature suggest that the cellular mechanisms underlying STE-induced toxicity include the induction of oxidative stress, mitochondrial…

Identification of a Functional Homolog of the Yeast Copper Homeostasis Gene ATX1 from Arabidopsis1

1998

Abstract A cDNA clone encoding a homolog of the yeast (Saccharomyces cerevisiae) gene Anti-oxidant 1(ATX1) has been identified from Arabidopsis. This gene, referred to as CopperCHaperone(CCH), encodes a protein that is 36% identical to the amino acid sequence of ATX1 and has a 48-amino acid extension at the C-terminal end, which is absent from ATX1 homologs identified in animals. ATX1-deficient yeast (atx1) displayed a loss of high-affinity iron uptake. Expression of CCH in the atx1 strain restored high-affinity iron uptake, demonstrating thatCCH is a functional homolog of ATX1. When overexpressed in yeast lacking the superoxide dismutase geneSOD1, both ATX1 and CCHprotected the cell from t…