6533b82ffe1ef96bd1295a0e
RESEARCH PRODUCT
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subject
endocrine system diseasesEndotheliumPharmaceutical ScienceOxidative phosphorylationResveratrolPharmacologymedicine.disease_causeAnalytical ChemistryNitric oxidechemistry.chemical_compoundEnosDrug DiscoverymedicinePhysical and Theoretical ChemistrybiologySuperoxideorganic chemicalsOrganic Chemistryfood and beveragesAMPKbiology.organism_classificationmedicine.anatomical_structureBiochemistrychemistryChemistry (miscellaneous)Molecular Medicinehormones hormone substitutes and hormone antagonistsOxidative stressdescription
Nitric oxide (NO) derived from the endothelial NO synthase (eNOS) has antihypertensive, antithrombotic, anti-atherosclerotic and antiobesogenic properties. Resveratrol is a polyphenol phytoalexin with multiple cardiovascular and metabolic effects. Part of the beneficial effects of resveratrol are mediated by eNOS. Resveratrol stimulates NO production from eNOS by a number of mechanisms, including upregulation of eNOS expression, stimulation of eNOS enzymatic activity and reversal of eNOS uncoupling. In addition, by reducing oxidative stress, resveratrol prevents oxidative NO inactivation by superoxide thereby enhancing NO bioavailability. Molecular pathways underlying these effects of resveratrol involve SIRT1, AMPK, Nrf2 and estrogen receptors.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2014-10-09 | Molecules |