Search results for " STRESS"

Mobile-based intervention based on acceptance and commitment therapy : the effectiveness on work ability and perceived stress for individuals with sy…

2015

Tässä tutkimuksessa tutkittiin hyväksymis- ja omistautumisterapiaan perustuvan hyvinvointiohjelman Oivan älypuhelinsovelluksen tehokkuutta työkykyyn ja koettuun stressiin yksilöillä, jotka kärsivät metabolisenoireyhtymän oireista ja psykologisesta stressistä. Satunnaistetussa vertailukokeessa tutkittiin 8-viikon intervention avulla älypuhelimeen sovelletun ohjelman tehokkuutta tietoisuustaitojen (mindfulness) ja hyväksymis- ja arvopohjaisten harjoituksien pohjalta. Lisäksi oltiin kiinnostuneita välittääkö psykologinen joustavuus suhteessa työkykyyn ja koettuun stressiin intervention vaikutuksia. Tutkimus sisälsi alkumittaukset ennen 8-viikon interventiota ja seurantamittaukset 36 viikkoa al…

Taloudellinen stressi ja sen yhteydet parisuhteen ja vanhemmuuden laatuun

2000

STUDY REGARDING OCCUPATIONAL STRESS MANAGEMENT IN THE LOCAL PUBLIC ADMINISTRATION WITH THE PURPOSE OF IMPROVING THE QUALITY OF THE SERVICES RENDERED

2013

The paper aims at highlighting the implications of a certain psycho-social factor in a chosen unit - local public administration.The case study for the analyzed public institution has been elaborated based on different problems which come up during working hours and after several discussions with public employees from within several of the institution's structures.In the current context, one places emphasis more and more on the study of occupational stress, so that we have considered opportune the elaboration of an adequate study with distinctiveness on the local administration type of organization, with emphasis on improving the services rendered with the purpose of increasing citizen sati…

Purīnu auksotrofijas ietekme uz maizes rauga S. cerevisiae subletālo stresu izturību

2016

Darbā tika pārbaudīta maizes rauga stresa izturība purīnu trūkuma gadījumā. Ietekme uz izdzīvotību tika novērtēta audzējot gan auksotrofu, gan prototrofa celmu šūnas barotnēs ar atšķirīgu oglekļa avotu un purīnu sastāvu, pēc tam visus paraugus pakļaujot subletālam oksidatīvajam, termiskajam vai vāju skābju stresam stresam un novērtējot izdzīvotību. Darbā konstatēts, ka adenīna trūkums izraisa visu trīs pētīto stresu izturības pieaugumu. Oksidatīvā stresa izturības pieaugums var tikt izskaidrots ar elpošanas pieaugumu purīna trūkuma gadījumā, bet termiskā un vāju skābju stresa izturība nepieaug pie oksidatīva oglekļa avota, bet to ietekmē guanīna klātbūtne. Rezultāti ļauj secināt, ka purīnu …

Prevalencia de riesgos psicosociales en personal de la administración de justicia de la comunidad valenciana (España) / Prevalence of psychosocial ri…

2016

RESUMEN: El objetivo del estudio fue evaluar los factores psicosociales en el trabajo del personal de justicia de la Comunidad Valencia (España) para identificar la prevalencia de riesgos psicosociales. Participaron 402 trabajadores (28.11 % hombres) incluyendo gestores, tramitadores y auxiliares sociales. Se evaluó con la Batería UNIPSICO (incluye factores de demanda, factores de recursos y consecuencias de los riesgos psicosociales). Los principales riesgos fueron la sobrecarga de trabajo (46.02 % de participantes en situación de alto riesgo) dentro de las demandas, la falta de recursos para realizar el trabajo (76.37 % en situación de alto riesgo) y la falta de autonomía (67.41 % en situ…

Aplidin® induces JNK-dependent apoptosis in human breast cancer cells via alteration of glutathione homeostasis, Rac1 GTPase activation, and MKP-1 ph…

2006

Aplidin® is an antitumor agent in phase II clinical trials that induces apoptosis through the sustained activation of Jun N-terminal kinase (JNK). We report that Aplidin® alters glutathione homeostasis increasing the ratio of oxidized to reduced forms (GSSG/GSH). Aplidin® generates reactive oxygen species and disrupts the mitochondrial membrane potential. Exogenous GSH inhibits these effects and also JNK activation and cell death. We found two mechanisms by which Aplidin® activates JNK: rapid activation of Rac1 small GTPase and downregulation of MKP-1 phosphatase. Rac1 activation was diminished by GSH and enhanced by L-buthionine (SR)-sulfoximine, which inhibits GSH synthesis. Downregulatio…

Physical inactivity increases oxidative stress, endothelial dysfunction, and atherosclerosis.

2005

Objective— Sedentary lifestyle is associated with increased cardiovascular events. The underlying molecular mechanisms are incompletely understood. Reactive oxygen species (ROS) contribute to endothelial dysfunction and atherosclerosis. An important source of vascular ROS is the NADPH oxidase. Methods and Results— C57BL6 mice were subjected to regular housing (physical inactivity) or voluntary training on running wheels (6 weeks). Inactivity increased vascular lipid peroxidation to 148±9% and upregulated superoxide release to 176±17% (L-012 chemiluminescence) and 188±29% (cytochrome C reduction assay), respectively. ROS production was predominantly increased in the endothelium and the medi…

Antioxidant Therapies and Oxidative Stress in Friedreich´s Ataxia: The Right Path or Just a Diversion?

2020

Friedreich's ataxia is the commonest autosomal recessive ataxia among population of European descent. Despite the huge advances performed in the last decades, a cure still remains elusive. One of the most studied hallmarks of the disease is the increased production of oxidative stress markers in patients and models. This feature has been the motivation to develop treatments that aim to counteract such boost of free radicals and to enhance the production of antioxidant defenses. In this work, we present and critically review those 'antioxidant' drugs that went beyond the disease's models and were approved for its application in clinical trials. The evaluation of these trials highlights some …

The Role of Work-Nonwork Boundary Management in Work Stress Recovery

2016

The aim of the present study conducted among 1,106 Finnish employees was to identify boundary management profiles based on cross-role interruption behaviors from work to nonwork and from nonwork to work. Adopting a person-oriented approach through latent profile analysis, 5 profiles were identified: Work Guardians (21% of the employees), Nonwork Guardians (14%), Integrators (25%), Separators (18%), and an Intermediate Group (22%). We then examined differences between these profiles with respect to recovery experiences (psychological detachment from work, relaxation, mastery experiences, and control during off-job time) and recovery outcomes (vigor and exhaustion). Work Guardians had the poo…

Plasma redox response of Sicilian Opuntia Ficus Indica juice in young physically active women.

2017

It is known amateur female athletes show an altered redox status [1] and the consumption of Opuntia Ficus Indica (OFI) decreases oxidative stress (OS) in healthy humans [2]. Therefore, the aim of this study was to investigate whether the supplementation with Sicilian OFI juice affected plasma redox balance following a maximal effort test in young physically active women
 . This study was randomized, double blind, placebo controlled and crossover design. Eight women (23.25±2.95 years old, weight of 54.13±9.05 kg, height of 157.75±0.66 cm and BMI of 21.69±0.66 kg/m2) were randomly divided into 2 groups and each group was supplied with either 50 ml OFI, diluted to 170 ml with water, or 170 ml …