Search results for " Sang"

Enfermedad injerto contra huésped en el trasplante de sangre de cordón umbilical de donante no emparentado en adultos con enfermedades hematológicas …

2019

Comparado con la sangre periférica y la médula ósea como fuentes de progenitores hematopoyéticos de donante no emparentado, la sangre de cordón umbilical desencadena una menor alorreactividad contra el receptor, lo que permite el uso de donantes con una mayor disparidad del sistema HLA. Un menor número de linfocitos T en la unidades de cordón umbilical (UCU), pero con un mayor porcentaje de linfocitos T naive, explica en parte la menor incidencia de enfermedad injerto contra huésped (EICH) en el trasplante de sangre de cordón umbilical (TSCU) en comparación con otras fuentes. Sin embargo, este porcentaje relativamente bajo no impide que esta complicación contribuya directa e indirectamente …

Herramienta clínica para la búsqueda de biomarcadores de enfermedades neurológicas

2009

El solapamiento que presentan algunas enfermedades neurologicas en la clinica justifica la necesidad de establecer biomarcadores que sirvan como apoyo en el diagnostico y seguimiento de la enfermedad. El analisis de los fluidos intracraneales (sangre y liquido cefalorraquideo) juega un rol importante en la busqueda de estos biomarcadores. Las secuencias dinamicas de resonancia magnetica en contraste de fase (RM-CF) con sincronismo cardiaco permiten cuantificar el flujo de liquido cefalorraquideo (LCR) y de la sangre durante un ciclo cardiaco. No obstante, la medicion de flujo mediante secuencias de imagenes de RM-CF (IRM-CF) es precisa y reproducible siempre que se use un protocolo de adqui…

Clinical Phenotype and Response to Different Lines of Therapy in Elderly with Immune Thrombocytopenia: A Retrospective Study

2020

Salvatrice Mancuso,1 Melania Carlisi,1 Nicola Serra,2,3 Mariasanta Napolitano,1 Simona Raso,3 Ugo Consoli,4 Roberto Palazzolo,5 Maria Rosa Lanza Cariccio,6 Sergio Siragusa1 1Health Promotion Sciences, Maternal and Infant Care, Internal Medicine and Medical Specialties (PROMISE) Department, University of Palermo, Palermo, Italy; 2Department of Molecular Medicine and Medical Biotechnology, University Federico II of Naples, Naples, Italy; 3Department of Surgical, Oncological and Stomatological Disciplines, University of Palermo, Palermo, Italy; 4UOC Ematologia ARNAS Garibaldi, Catania, Italy; 5UOS Ematologia, Asst Valtellina e Alto Lario, Sondrio, Italy; 6Dipartimento Oncologico, La Maddalena,…

Effects of B-Cell Lymphoma on the Immune System and Immune Recovery after Treatment: The Paradigm of Targeted Therapy

2022

B-cell lymphoma and lymphoproliferative diseases represent a heterogeneous and complex group of neoplasms that are accompanied by a broad range of immune regulatory disorder phenotypes. Clinical features of autoimmunity, hyperinflammation, immunodeficiency and infection can variously dominate, depending on the immune pathway most involved. Immunological imbalance can play a role in lymphomagenesis, also supporting the progression of the disease, while on the other hand, lymphoma acts on the immune system to weaken immunosurveillance and facilitate immunoevasion. Therefore, the modulation of immunity can have a profound effect on disease progression or resolution, which makes the immune syst…

Valore predittivo di variabili clinico-laboratoristiche in pazienti con mielofibrosi trattati con inibitore di JAK-1/2

2011

Elevated CO2 emissions during magmatic-hydrothermal degassing at Awu Volcano, Sangihe Arc, Indonesia

2020

Awu is a remote and little known active volcano of Indonesia located in the northern part of Molucca Sea. It is the northernmost active volcano of the Sangihe arc with 18 eruptions in less than 4 centuries, causing a cumulative death toll of 11,048. Two of these eruptions were classified with a Volcanic Explosivity Index (VEI) of 4. Since 2004, a lava dome has occupied the centre of Awu crater, channelling the fumarolic gas output along the crater wall. A combined Differential Optical Absorption Spectroscopy (DOAS) and Multi-component Gas Analyzer System (Multi-GAS) study highlight a relatively small SO2 flux (13 t/d) sustained by mixed magmatic&ndash

Prevalence of left ventricular hypertrophy in children and young people with primary hypertension: Meta-analysis and meta-regression

2022

BackgroundLeft ventricular hypertrophy (LVH) is the main marker of HMOD in children and young people (CYP). We aimed to assess the prevalence of LVH and its determinants in CYP with primary hypertension (PH).MethodsA meta-analysis of prevalence was performed. A literature search of articles reporting LVH in CYP with PH was conducted in Medline, Embase, and Cochrane databases. Studies with a primary focus on CYP (up to 21 years) with PH were included. Meta-regression was used to analyze factors explaining observed heterogeneity.ResultsThe search yielded a total of 2,200 articles, 153 of those underwent full-text review, and 47 reports were included. The reports evaluated 51 study cohorts inc…

Transfusion Need at Diagnosis or Its Development During the First Year of Diagnosis in Primary Myelofibrosis: Effect On Survival and Correlation with…

2009

Abstract Abstract 1909 Poster Board I-932 Background: The International Prognostic Scoring System (IPSS) for primary myelofibrosis (PMF) utilizes five independent predictors of inferior survival; of these, a hemoglobin level <10 g/dL has the highest impact on survival (Cervantes et al. Blood 2009;113:2895). In the current study, we examined the additional prognostic impact of transfusion need at diagnosis or becoming transfusion-dependent in the first year of diagnosis. These events were also correlated with JAK2 or TET2 mutational status. Methods: Patients were selected from the Mayo Clinic PMF database based on availability of bone marrow histology and IPSS-relevant information at diag…

Comprehensive geriatric assessment is an essential tool to support treatment decisions in elderly patients with diffuse large B-cell lymphoma: A pros…

2015

We performed a multicenter study to validate the concept that a simple comprehensive geriatric assessment (CGA) can identify elderly, non-fit patients with diffuse large B-cell lymphoma (DLBCL) in whom curative treatment is not better then palliation, and to analyze potential benefits of treatment modulation after further subdividing the non-fit category by CGA criteria. One hundred and seventy-three patients aged > 69 treated with curative or palliative intent by clinical judgement only were grouped according to CGA into fit (46%), unfit (16%) and frail (38%) categories. Two-year overall survival (OS) was significantly better in fit than in non-fit patients (84% vs. 47%; p < 0.0001).…

Absence of residual vein thrombosis after an episode of idiopatic deep vein thrombosis: short-term anticoagulation is safe. The extended DACUS Study

2009

Abstract Background. The optimal duration of Oral Anticoagulant Therapy (OAT) for Deep Vein Thrombosis (DVT) can be tailored by Residual Vein Thrombosis (RVT) (Siragusa S et al. Blood2003;102(11):OC183), a marker able to assess the individual risk for recurrent thrombosis. However, in patients with idiopathic DVT the safety of early interruption of OAT, because of absence of RVT, is still debated. Objective of the study. In the present study, we evaluated the safety of withholding OAT, in patients with idiopathic DVT and without RVT, three months after the index thrombotic episode. Study design. Prospective controlled study with two groups: patients without RVT stopped OAT after 3 months wh…